Considerations for widespread implementation of blood-based biomarkers of Alzheimer's disease.
Document Type
Article
Abstract
Diagnosing Alzheimer's disease (AD) poses significant challenges to health care, often resulting in delayed or inadequate patient care. The clinical integration of blood-based biomarkers (BBMs) for AD holds promise in enabling early detection of pathology and timely intervention. However, several critical considerations, such as the lack of consistent guidelines for assessing cognition, limited understanding of BBM test characteristics, insufficient evidence on BBM performance across diverse populations, and the ethical management of test results, must be addressed for widespread clinical implementation of BBMs in the United States. The Global CEO Initiative on Alzheimer's Disease BBM Workgroup convened to address these challenges and provide recommendations that underscore the importance of evidence-based guidelines, improved training for health-care professionals, patient empowerment through informed decision making, and the necessity of community-based studies to understand BBM performance in real-world populations. Multi-stakeholder engagement is essential to implement these recommendations and ensure credible guidance and education are accessible to all stakeholders.
Medical Subject Headings
Humans; Alzheimer Disease; Biomarkers; United States; Early Diagnosis
Publication Date
11-1-2024
Publication Title
Alzheimers Dement
ISSN
1552-5279
Volume
20
Issue
11
First Page
8209
Last Page
8215
PubMed ID
39369283
Digital Object Identifier (DOI)
10.1002/alz.14150
Recommended Citation
Mielke, Michelle M; Anderson, Matthew; Ashford, J Wesson; Jeromin, Andreas; Lin, Pei-Jung; Rosen, Allyson; Tyrone, Jamie; VandeVrede, Lawren; Willis, Deanna; Hansson, Oskar; Khachaturian, Ara S; Schindler, Suzanne E; Weiss, Joan; Batrla, Richard; Bozeat, Sasha; Dwyer, John R; Holzapfel, Drew; Jones, Daryl Rhys; Murray, James F; Partrick, Katherine A; Scholler, Emily; Vradenburg, George; Young, Dylan; Braunstein, Joel B; Burnham, Samantha C; de Oliveira, Fabricio Ferreira; Hu, Yan Helen; Mattke, Soeren; Merali, Zul; Monane, Mark; Sabbagh, Marwan Noel; Shobin, Eli; Weiner, Michael W; and Udeh-Momoh, Chinedu T, "Considerations for widespread implementation of blood-based biomarkers of Alzheimer's disease." (2024). Neurology. 1911.
https://scholar.barrowneuro.org/neurology/1911