Proof-of-concept for characterization of neurodegenerative disorders utilizing two non-REM sleep biomarkers.

Document Type

Article

Abstract

STUDY OBJECTIVE: This proof-of-concept study aimed to determine whether the combined features of two non-rapid eye movement (NREM) sleep biomarkers acquired predominantly in-home could characterize different neurodegenerative disorders.

METHODS: Sleep spindle duration and non-REM hypertonia (NRH) were evaluated in seven groups including a control group (CG = 61), and participants with isolated REM sleep behavior disorder (iRBD = 19), mild cognitive impairment (MCI = 41), Parkinson disease (PD = 16), Alzheimer disease dementia (ADem = 29), dementia with Lewy Bodies or Parkinson disease dementia (LBD = 19) and progressive supranuclear palsy (PSP = 13). One-way analysis of variance (ANOVA), Mann-Whitney

RESULTS: ANOVA identified group differences in age, sleep efficiency, REM, NRH (

CONCLUSION: The NREM sleep biomarkers spindle duration and NRH may be useful in distinguishing patients with different neurodegenerative disorders. Larger prospective cohort studies are needed to determine whether spindle duration and NRH can be combined for prodromal assessment and/or monitoring disease progression.

Publication Date

1-1-2023

Publication Title

Front Neurol

ISSN

1664-2295

Volume

14

First Page

1272369

Last Page

1272369

PubMed ID

37928153

Digital Object Identifier (DOI)

10.3389/fneur.2023.1272369

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