White matter hyperintensity longitudinal morphometric analysis in association with Alzheimer disease

Jeremy Fuller Strain, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Chia-Ling Phuah, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Babatunde Adeyemo, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Kathleen Cheng, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Kyle B. Womack, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
John McCarthy, Department of Mathematics, Washington University School of Medicine, St. Louis, Missouri, USA.
Manu Goyal, Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Yasheng Chen, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Aristeidis Sotiras, Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Hongyu An, Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Chengjie Xiong, Division of Biostatics, Washington University School of Medicine, St. Louis, Missouri, USA.
Andrea Scharf, Department of Biological Sciences, Missouri University for Science and Technology, Rolla, Missouri, USA.
Catherine Newsom-Stewart, Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
John Carl Morris, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Tammie Lee Benzinger, Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Jin-Moo Lee, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Beau M. Ances, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.

Document Type

Article

Abstract

INTRODUCTION: Vascular damage in Alzheimer's disease (AD) has shown conflicting findings particularly when analyzing longitudinal data. We introduce white matter hyperintensity (WMH) longitudinal morphometric analysis (WLMA) that quantifies WMH expansion as the distance from lesion voxels to a region of interest boundary. METHODS: WMH segmentation maps were derived from 270 longitudinal fluid-attenuated inversion recovery (FLAIR) ADNI images. WLMA was performed on five data-driven WMH patterns with distinct spatial distributions. Amyloid accumulation was evaluated with WMH expansion across the five WMH patterns. RESULTS: The preclinical group had significantly greater expansion in the posterior ventricular WM compared to controls. Amyloid significantly associated with frontal WMH expansion primarily within AD individuals. WLMA outperformed WMH volume changes for classifying AD from controls primarily in periventricular and posterior WMH. DISCUSSION: These data support the concept that localized WMH expansion continues to proliferate with amyloid accumulation throughout the entirety of the disease in distinct spatial locations.

Medical Subject Headings

Humans; Alzheimer Disease (pathology); White Matter (diagnostic imaging, pathology); Magnetic Resonance Imaging

Publication Date

10-1-2023

Publication Title

Alzheimer's & dementia : the journal of the Alzheimer's Association

E-ISSN

1552-5279

Volume

19

Issue

10

First Page

4488

Last Page

4497

PubMed ID

37563879

Digital Object Identifier (DOI)

10.1002/alz.13377

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