ALSUntangled #68: ozone therapy.
Document Type
Article
Abstract
ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review ozone therapy. Ozone therapy has possible mechanisms for slowing ALS progression based on its antioxidant, anti-inflammatory, and mitochondrial effects. A non-peer-reviewed report suggests that ozone treatment may slow progression in a mTDP-43 mouse model of ALS. One verified "ALS reversal" occurred on a cocktail of alternative treatments including ozone. There are no ALS trials using ozone to treat PALS. There can be potentially serious side effects associated with ozone therapy, depending on the dose. Based on the above information, we support an investigation of ozone therapy in ALS cell or animal models but cannot yet recommend it as a treatment in PALS.
Medical Subject Headings
Mice; Animals; Humans; Amyotrophic Lateral Sclerosis; Disease Models, Animal; Mitochondria
Publication Date
8-1-2023
Publication Title
Amyotroph Lateral Scler Frontotemporal Degener
ISSN
2167-9223
Volume
24
Issue
5-6
First Page
548
Last Page
552
PubMed ID
36398749
Digital Object Identifier (DOI)
10.1080/21678421.2022.2145904
Recommended Citation
Sun, Yuyao; Barkhaus, Paul; Barnes, Benjamin; Beauchamp, Morgan; Benatar, Michael; Bertorini, Tulio; Bromberg, Mark; Carter, Gregory T; Crayle, Jesse; Cudkowicz, Merit; Dimachkie, Mazen; Feldman, Eva L; Fullam, Timothy; Heiman-Patterson, Terry; Jhooty, Sartaj; Lund, Isaac; Mcdermott, Christopher; Pattee, Gary; Pierce, Kaitlyn; Ratner, Dylan; Wicks, Paul; and Bedlack, Richard, "ALSUntangled #68: ozone therapy." (2023). Neurology. 1998.
https://scholar.barrowneuro.org/neurology/1998