Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group

Alexander Olsen, Department of Psychology, Norwegian University of Science and Technology, 7491, Trondheim, Norway. alexander.olsen@ntnu.no.
Talin Babikian, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Erin D. Bigler, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Karen Caeyenberghs, Cognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood, Australia.
Virginia Conde, Department of Psychology, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
Kristen Dams-O'Connor, Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ekaterina Dobryakova, Center for Traumatic Brain Injury, Kessler Foundation, East Hanover, NJ, USA.
Helen Genova, Center for Traumatic Brain Injury, Kessler Foundation, East Hanover, NJ, USA.
Jordan Grafman, Cognitive Neuroscience Laboratory, Shirley Ryan AbilityLab, Chicago, IL, USA.
Asta K. Håberg, Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Ingrid Heggland, Section for Collections and Digital Services, NTNU University Library, Norwegian University of Science and Technology, Trondheim, Norway.
Torgeir Hellstrøm, Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway.
Cooper B. Hodges, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Andrei Irimia, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Ruchira M. Jha, Departments of Critical Care Medicine, Neurology, Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.Follow
Paula K. Johnson, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Vassilis E. Koliatsos, Departments of Pathology(Neuropathology), Neurology, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Harvey Levin, H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Lucia M. Li, C3NL, Imperial College London, London, UK.
Hannah M. Lindsey, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Abigail Livny, Department of Diagnostic Imaging, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel.
Marianne Løvstad, Sunnaas Rehabilitation Hospital, Nesodden, Norway.
John Medaglia, Department of Psychology, Drexel University, Philadelphia, PA, USA.
David K. Menon, Division of Anaesthesia, University of Cambridge, Cambridge, UK.
Stefania Mondello, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
Martin M. Monti, Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA.
Virginia F. Newcombe, Division of Anaesthesia, University of Cambridge, Cambridge, UK.
Agustin Petroni, Department of Psychology, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
Jennie Ponsford, Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia.
David Sharp, Department of Brain Sciences, Imperial College London, London, UK.
Gershon Spitz, Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia.
Lars T. Westlye, Department of Psychology, University of Oslo, Oslo, Norway.

Document Type

Article

Abstract

The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers world-wide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with non-imaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for large-scale neuroimaging data analysis. In this consensus statement we outline the working group's short-term, intermediate, and long-term goals.

Medical Subject Headings

Adult; Brain (diagnostic imaging); Brain Injuries, Traumatic; Humans; Magnetic Resonance Imaging; Neuroimaging; Reproducibility of Results

Publication Date

4-1-2021

Publication Title

Brain imaging and behavior

E-ISSN

1931-7565

Volume

15

Issue

2

First Page

526

Last Page

554

PubMed ID

32797398

Digital Object Identifier (DOI)

10.1007/s11682-020-00313-7

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