Resting-state EEG predicts cognitive decline in a neuropathologically diagnosed longitudinal community autopsied cohort.
Document Type
Article
Abstract
OBJECTIVE: To assess correlative strengths of quantitative electroencephalography (qEEG) and visual rating scale EEG features on cognitive outcomes in only autopsied cases from the Arizona Study of Neurodegenerative Disorders (AZSAND). We hypothesized that autopsy proven Parkinson Disease will show distinct EEG features from Alzheimer's Disease prior to dementia (mild cognitive impairment).
BACKGROUND: Cognitive decline is debilitating across neurodegenerative diseases. Resting-state EEG analysis, including spectral power across frequency bins (qEEG), has shown significant associations with neurodegenerative disease classification and cognitive status, with autopsy confirmed diagnosis relatively lacking.
METHODS: Biannual EEG was analyzed from autopsied cases in AZSAND who had at least one rsEEG (>1 min eyes closed±eyes open). Analysis included global relative spectral power and a previously described visual rating scale (VRS). Linear mixed regression was performed for neuropsychological assessment and testing within 2 years of death (n = 236, 594 EEG exams) in a mixed linear regression model.
RESULTS: The cohort included cases with final clinicopathologic diagnoses of Parkinson's disease (n = 73), Alzheimer disease (n = 65), and tauopathy not otherwise specified (n = 56). A VRS score of 3 diffuse or frequent generalized slowing) over the study duration was associated with an increase in consensus diagnosis cognitive worsening at 4.9 (3.1) years (HR 2.02, CI 1.05-3.87). Increases in global theta power% and VRS were the most consistently associated with large regression coefficients inversely with cognitive performance measures.
CONCLUSION: Resting-state EEG analysis was meaningfully related to cognitive performance measures in a community-based autopsy cohort. EEG deserves further study and use as a cognitive biomarker.
Medical Subject Headings
Humans; Female; Male; Electroencephalography; Aged; Cognitive Dysfunction; Alzheimer Disease; Aged, 80 and over; Longitudinal Studies; Parkinson Disease; Autopsy; Tauopathies; Middle Aged; Cohort Studies
Publication Date
11-1-2024
Publication Title
Parkinsonism & related disorders
ISSN
1873-5126
Volume
128
First Page
107120
Last Page
107120
PubMed ID
39236511
Digital Object Identifier (DOI)
10.1016/j.parkreldis.2024.107120
Recommended Citation
Choi, Alexander; Zhang, Nan; Adler, Charles H; Beach, Thomas G; Shill, Holly A; Driver-Dunckley, Erika; Mehta, Shyamal; Belden, Christine; Atri, Alireza; Sabbagh, Marwan N; and Caviness, John N, "Resting-state EEG predicts cognitive decline in a neuropathologically diagnosed longitudinal community autopsied cohort." (2024). Neurology. 1906.
https://scholar.barrowneuro.org/neurology/1906