Stress Hyperglycemia and Prognosis of Minor Ischemic Stroke and Transient Ischemic Attack: The CHANCE Study (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events).

Document Type

Article

Abstract

BACKGROUND AND PURPOSE: We aimed to determine the association between stress hyperglycemia and risk of new stroke in patients with a minor ischemic stroke or transient ischemic attack.

METHODS: A subgroup of 3026 consecutive patients from 73 prespecified sites of the CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) were analyzed. Stress hyperglycemia was measured by glucose/glycated albumin (GA) ratio. Glucose/GA ratio was calculated by fasting plasma glucose divided by GA and categorized into 4 even groups according to the quartiles. The primary outcome was a new stroke (ischemic or hemorrhagic) at 90 days. We assessed the association between glucose/GA ratio and risk of stroke by multivariable Cox regression models adjusted for potential covariates.

RESULTS: Among 3026 patients included, a total of 299 (9.9%) new stroke occurred at 3 months. Compared with patients with the lowest quartile, patients with the highest quartile of glucose/GA ratio was associated with an increased risk of stroke at 3 months after adjusted for potential covariates (12.0% versus 9.2%; adjusted hazard ratio, 1.46; 95% confidence interval, 1.06-2.01). Similar results were observed after further adjusted for fasting plasma glucose. We also observed that higher level of glucose/GA ratio was associated with an increased risk of stroke with a threshold of 0.29 using a Cox regression model with restricted cubic spline.

CONCLUSIONS: Stress hyperglycemia, measured by glucose/GA ratio, was associated with an increased risk of stroke in patients with a minor ischemic stroke or transient ischemic attack.

CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00979589.

Medical Subject Headings

Acute Disease; Adult; Aged; Aged, 80 and over; Blood Glucose; Brain Ischemia; Clopidogrel; Double-Blind Method; Female; Glycation End Products, Advanced; Humans; Hyperglycemia; Male; Middle Aged; Risk Factors; Serum Albumin; Stroke; Ticlopidine; Glycated Serum Albumin

Publication Date

11-1-2017

Publication Title

Stroke; a journal of cerebral circulation

ISSN

1524-4628

Volume

48

Issue

11

First Page

3006

Last Page

3011

PubMed ID

29051218

Digital Object Identifier (DOI)

10.1161/STROKEAHA.117.019081

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