In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence.

Authors

A T Hillmer
C M Sandiego
J Hannestad
G A Angarita
A Kumar
E M McGovern
Y Huang
K C O'Connor
R E Carson
S S O'Malley
K P Cosgrove

Document Type

Article

Abstract

Neuroinflammation may be a critical component of the neurobiology of alcohol use disorders, yet the exact nature of this relationship is not well understood. This work compared the brain and peripheral immune profile of alcohol-dependent subjects and controls. Brain levels of 18-kDa translocator protein (TSPO), a marker of microglial activation and neuroinflammation, were measured with [

Medical Subject Headings

Acetamides; Adult; Alcoholism; Brain; Brain Mapping; Carbon Radioisotopes; Cells, Cultured; Cytokines; Female; Humans; Inflammation; Lipopolysaccharides; Male; Microglia; Monocytes; Neuroimaging; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Pyridines; Radiopharmaceuticals; Receptors, GABA; Severity of Illness Index

Publication Date

12-1-2017

Publication Title

Molecular psychiatry

ISSN

1476-5578

Volume

22

Issue

12

First Page

1759

Last Page

1766

PubMed ID

28242869

Digital Object Identifier (DOI)

10.1038/mp.2017.10

Recommended Citation

Hillmer, A T; Sandiego, C M; Hannestad, J; Angarita, G A; Kumar, A; McGovern, E M; Huang, Y; O'Connor, K C; Carson, R E; O'Malley, S S; and Cosgrove, K P, "In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence." (2017). Neurology. 1676.
https://scholar.barrowneuro.org/neurology/1676