The Department of Neurology at Barrow Neurological Institute is comprised of multiple subspecialty areas. We see outpatients with neurological symptoms, and also have a busy inpatient service taking care of patients with the wide range of neurological illnesses.

Our mission is to provide excellent patient care, train the next generation of neurologists including medical students, neurology residents, and subspecialty fellows, and to perform cutting edge research that will improve the lives of our patients.

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Submissions from 2023

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Predictors of matching into an ophthalmology fellowship for international medical graduates: a San Francisco match analysis, Muhammad Ali, Safa Saeed, Sidra Zafar, Karl C. Golnik, and Fasika Woreta

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Cerebral white matter rarefaction has both neurodegenerative and vascular causes and may primarily be a distal axonopathy, Thomas G. Beach, Lucia I. Sue, Sarah Scott, Anthony J. Intorcia, Jessica E. Walker, Richard A. Arce, Michael J. Glass, Claryssa I. Borja, Madison P. Cline, Spencer J. Hemmingsen, Sanaria Qiji, Analisa Stewart, Kayleigh N. Martinez, Addison Krupp, Rylee McHattie, Monica Mariner, Ileana Lorenzini, Angela Kuramoto, Kathy E. Long, Cécilia Tremblay, Richard J. Caselli, Bryan K. Woodruff, Steven Z. Rapscak, Christine M. Belden, Danielle Goldfarb, Parichita Choudhury, Erika D. Driver-Dunckley, Shyamal H. Mehta, Marwan N. Sabbagh, Holly A. Shill, Alireza Atri, and Charles H. Adler

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Missorting of plasma miRNAs in aging and Alzheimer's disease, Maria Čarna, Jan S. Novotny, Neda Dragišić, Hanuš Slavik, Kateřina Sheardova, Yonas E. Geda, Martin Vyhnalek, Jan Laczo, Jakub Hort, Zixu Mao, Robert A. Rissman, Marian Hajduch, Eric B. Dammer, and Gorazd B. Stokin

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Outcomes in patients with aneurysmal subarachnoid hemorrhage receiving sulfonylureas: a propensity-adjusted analysis, Joshua S. Catapano, Stefan W. Koester, Kamila M. Bond, Visish M. Srinivasan, Dara S. Farhadi, Kavelin Rumalla, Tyler S. Cole, Jacob F. Baranoski, Ethan A. Winkler, Christopher S. Graffeo, Amanda Muñoz-Casabella, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, Michael T. Lawton, and Ruchira M. Jha

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Incidence and Prediction of Chronic Depression Following Aneurysmal Subarachnoid Hemorrhage: A Single-Center 17-Year Experience, Joshua S. Catapano, Kavelin Rumalla, Stefan W. Koester, Ethan A. Winkler, Robert F. Rudy, Tyler S. Cole, Jacob F. Baranoski, Christopher S. Graffeo, Visish M. Srinivasan, Ruchira M. Jha, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton

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Association between physical activity and longitudinal change in body mass index in middle-aged and older adults, Laura Cleven, Jeremy A. Syrjanen, Yonas E. Geda, Luke R. Christenson, Ronald C. Petersen, Maria Vassilaki, Alexander Woll, and Janina Krell-Roesch

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GO-ing for Gold: Global Perspectives on Creating a Gold Standard for Global Ophthalmology (GO) Education, Emily Cole, Wanjiku Mathenge, Daniel Kiage, Thulasiraj Ravilla, Eduardo Mayorga, Ana G. Palis, Jacquelyn O'Banion, Karl Golnik, Jeff Pettey, Grace Sun, David Hunter Cherwek, Deepak Edward, Katherine Joltikov, R V. Chan, and Peter W. MacIntosh

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Neuroinflammation and white matter alterations in occupational manganese exposure assessed by diffusion basis spectrum imaging, Susan R. Criswell, Susan Searles Nielsen, Irene M. Faust, Joshua S. Shimony, Robert L. White, Jason Lenox-Krug, and Brad A. Racette

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Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis, Jessica Cummings, Yijen L. Wu, C Edward Dixon, Jeremy Henchir, J Marc Simard, Ashok Panigrahy, Patrick M. Kochanek, Ruchira M. Jha, and Rajesh K. Aneja

Baseline characteristics of the North American prodromal Synucleinopathy cohort., Jonathan E Elliott, Miranda M Lim, Allison T Keil, Ronald B Postuma, Amelie Pelletier, Jean-François Gagnon, Erik K St Louis, Leah K Forsberg, Julie A Fields, Daniel E Huddleston, Donald L Bliwise, Alon Y Avidan, Michael J Howell, Carlos H Schenck, Jennifer McLeland, Susan R Criswell, Aleksandar Videnovic, Emmanuel H During, Mitchell G Miglis, David R Shprecher, Joyce K Lee-Iannotti, Bradley F Boeve, and Yo-El S Ju

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A predictive algorithm to identify ever smoking in medical claims-based epidemiologic studies, Irene Faust, Mark Warden, Alejandra Camacho-Soto, Brad A. Racette, and Susan Searles Nielsen

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NANOS NOTE Neuro-Ophthalmology Techniques of Examination, Karl C. Golnik

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ARIA in patients treated with lecanemab (BAN2401) in a phase 2 study in early Alzheimer's disease, Lawrence S. Honig, Jerome Barakos, Shobha Dhadda, Michio Kanekiyo, Larisa Reyderman, Michael Irizarry, Lynn D. Kramer, Chad J. Swanson, and Marwan Sabbagh

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Efficacy and Safety of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease After 97 Weeks: A Phase 3 Randomized Clinical Trial, Priya S. Kishnani, Jordi Diaz-Manera, Antonio Toscano, Paula R. Clemens, Shafeeq Ladha, Kenneth I. Berger, Hani Kushlaf, Volker Straub, Gerson Carvalho, Tahseen Mozaffar, Mark Roberts, Shahram Attarian, Yin-Hsiu Chien, Young-Chul Choi, John W. Day, Sevim Erdem-Ozdamar, Sergey Illarioshkin, Ozlem Goker-Alpan, Anna Kostera-Pruszczyk, Ans T. van der Ploeg, Kristina An Haack, Olivier Huynh-Ba, Swathi Tammireddy, Nathan Thibault, Tianyue Zhou, Mazen M. Dimachkie, and Benedikt Schoser

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Propensity-adjusted analysis of ultra-early aneurysmal subarachnoid hemorrhage treatment and patient outcomes, Stefan W. Koester, Joshua S. Catapano, Emmajane G. Rhodenhiser, Robert F. Rudy, Ethan A. Winkler, Dimitri Benner, Tyler S. Cole, Jacob F. Baranoski, Visish M. Srinivasan, Christopher S. Graffeo, Ruchira M. Jha, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton

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Mid- and Late-Life Physical Activity and Neuropsychiatric Symptoms in Dementia-Free Older Adults: Mayo Clinic Study of Aging, Janina Krell-Roesch, Jeremy A. Syrjanen, Jelena Bezold, Sandra Trautwein, Bettina Barisch-Fritz, Walter K. Kremers, Julie A. Fields, Eugene L. Scharf, David S. Knopman, Gorazd B. Stokin, Ronald C. Petersen, Darko Jekauc, Alexander Woll, Maria Vassilaki, and Yonas E. Geda

Protective Effects of Lovastatin in a Population-Based ALS Study and Mouse Model., Collin J Kreple, Susan Searles Nielsen, Kathleen M Schoch, Tao Shen, Mark Shabsovich, Yizhe Song, Brad A Racette, and Timothy M Miller

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Faculty Development of CPD Teachers in Low-Resource Environments Post-COVID-19, Heather Mack, Karl Golnik, and Helena Prior Filipe

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Precision Medicine in Neurocritical Care for Cerebrovascular Disease Cases, Nils H. Petersen, Kevin N. Sheth, and Ruchira M. Jha

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Interactions Between Neuropsychiatric Symptoms and Alzheimer's Disease Neuroimaging Biomarkers in Predicting Longitudinal Cognitive Decline, Anna Pink, Janina Krell-Roesch, Jeremy A. Syrjanen, Luke R. Christenson, Val J. Lowe, Prashanthi Vemuri, Julie A. Fields, Gorazd B. Stokin, Walter K. Kremers, Eugene L. Scharf, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, Maria Vassilaki, and Yonas E. Geda

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Ophthalmology Surgical Assessment of Tube Shunt Glaucoma Surgery, Mary Qiu, Ema Avdagic, Pradeep Y. Ramulu, Karl Golnik, and Michael V. Boland

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Low-Dose Whole Brain Radiation Therapy for Alzheimer's Dementia: Results From a Pilot Trial in Humans, C Leland Rogers, Sarah K. Lageman, James Fontanesi, George D. Wilson, Peter A. Boling, Surbhi Bansal, John P. Karis, Marwan Sabbagh, Minesh P. Mehta, and Timothy J. Harris

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Hemoglobin Concentration Impacts Viscoelastic Hemostatic Assays in ICU Admitted Patients, David J. Roh, Tiffany R. Chang, Aditya Kumar, Devin Burke, Glenda Torres, Katherine Xu, Winni Yang, Azzurra Cottarelli, Ernest Moore, Angela Sauaia, Kirk Hansen, Angela Velazquez, Amelia Boehme, Athina Vrosgou, Shivani Ghoshal, Soojin Park, Sachin Agarwal, Jan Claassen, E Sander Connolly, Gebhard Wagener, Richard O. Francis, and Eldad Hod

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Socioeconomic Drivers of Outcomes After Aneurysmal Subarachnoid Hemorrhage Treatment at a Large Comprehensive Stroke Center, Kavelin Rumalla, Joshua S. Catapano, Varun Mahadevan, Samuel R. Sorkhi, Stefan W. Koester, Ethan A. Winkler, Christopher S. Graffeo, Visish M. Srinivasan, Ruchira M. Jha, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton

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Biomarker-based diagnosis of preclinical Alzheimer disease: time for the clinic?, Marwan N. Sabbagh and Boris DeCourt

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Listening session with the US Food and Drug Administration, Lewy Body Dementia Association, and an expert panel, Marwan N. Sabbagh, Angela Taylor, Douglas Galasko, James E. Galvin, Jennifer G. Goldman, James B. Leverenz, Kathleen L. Poston, Bradley F. Boeve, David J. Irwin, and Joseph F. Quinn

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Unmet needs in the diagnosis and treatment of Parkinson's disease psychosis and dementia-related psychosis, Marwan Sabbagh, Gary W. Small, Stuart H. Isaacson, Yasar Torres-Yaghi, Fernando Pagan, and Rajesh Pahwa

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Response to: Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke, Marwan Sabbagh and Christopher H. van Dyck

B-complex vitamins for patients with TANGO2-deficiency disorder., Sarah E Sandkuhler, Lilei Zhang, Joshua K Meisner, Lina Ghaloul-Gonzalez, Cheyenne M Beach, David Harris, Pascale de Lonlay, Seema R Lalani, Christina Y Miyake, and Samuel J Mackenzie

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Metabolomic profiles of human glioma inform patient survival, Andrew J. Scott, Luis O. Correa, Donna Edwards, Yilun Sun, Visweswaran Ravikumar, Anthony C. Andren, Li Zhang, Sudharsan Srinivasan, Neil Jairath, Kait Verbal, Karin Muraszko, Oren Sagher, Shannon A. Carty, Shawn Hervey-Jumper, Daniel Orringer, Michelle M. Kim, Larry Junck, Yoshie Umemura, Denise Leung, Sriram Venneti, Sandra Camelo-Piragua, Theodore S. Lawrence, Joseph E. Ippolito, Wajd N. Al-Holou, Prakash Chinnaiyan, Jason Heth, Arvind Rao, Costas A. Lyssiotis, and Daniel R. Wahl

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Neuropsychiatric Symptoms and Commonly Used Biomarkers of Alzheimer's Disease: A Literature Review from a Machine Learning Perspective, Jay Shah, Md Mahfuzur Rahman Siddiquee, Janina Krell-Roesch, Jeremy A. Syrjanen, Walter K. Kremers, Maria Vassilaki, Erica Forzani, Teresa Wu, and Yonas E. Geda

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Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke, Jesse A. Stokum, Bosung Shim, Serban Negoita, Natalya Tsymbalyuk, Orest Tsymbalyuk, Svetlana Ivanova, Kaspar Keledjian, Joseph Bryan, Mordecai P. Blaustein, Ruchira M. Jha, Kristopher T. Kahle, Volodymyr Gerzanich, and J Marc Simard

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Standardized perioperative care reduces colorectal surgical site infection in children: A Western Pediatric Surgery Research Consortium multicenter analysis, Joseph Tobias, Benjamin E. Padilla, Justin Lee, Stephanie Chen, Kasper S. Wang, Lorraine I. Kelley-Quon, Claudia Mueller, Stephen B. Shew, Katie Joskowitz, Romeo C. Ignacio, Lauren L. Evans, Aaron R. Jensen, Shannon N. Acker, Andrew Mason, Alicia Johnson, Jessica McConahey, Erik Hansen, Samir R. Pandya, Scott S. Short, Katie W. Russell, Lauren Nicassio, Caitlin A. Smith, and Elizabeth Fialkowski

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Lecanemab in Early Alzheimer's Disease. Reply, Christopher H. van Dyck, Marwan Sabbagh, and Sharon Cohen

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Lecanemab in Early Alzheimer's Disease, Christopher H. van Dyck, Chad J. Swanson, Paul Aisen, Randall J. Bateman, Christopher Chen, Michelle Gee, Michio Kanekiyo, David Li, Larisa Reyderman, Sharon Cohen, Lutz Froelich, Sadao Katayama, Marwan Sabbagh, Bruno Vellas, David Watson, Shobha Dhadda, Michael Irizarry, Lynn D. Kramer, and Takeshi Iwatsubo

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Lecanemab (BAN2401): an anti-beta-amyloid monoclonal antibody for the treatment of Alzheimer disease, Grace E. Vitek, Boris Decourt, and Marwan N. Sabbagh

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Factors Associated with Early Withdrawal of Life-Sustaining Treatments After Out-of-Hospital Cardiac Arrest: A Subanalysis of a Randomized Trial of Prehospital Therapeutic Hypothermia, Sarah Wahlster, Kyle Danielson, Lindy Craft, Nassim Matin, James A. Town, Vasisht Srinivasan, Glenn Schubert, David Carlbom, Francis Kim, Nicholas J. Johnson, and David Tirschwell

Neuroworsening in the Emergency Department Is a Predictor of Traumatic Brain Injury Intervention and Outcome: A TRACK-TBI Pilot Study., John K Yue, Nishanth Krishnan, John H Kanter, Hansen Deng, David O Okonkwo, Ava M Puccio, Debbie Y Madhok, Patrick J Belton, Britta E Lindquist, Gabriela G Satris, Young M Lee, Gray Umbach, Ann-Christine Duhaime, Pratik Mukherjee, Esther L Yuh, Alex B Valadka, Anthony M DiGiorgio, Phiroz E Tarapore, Michael C Huang, and Geoffrey T Manley

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GTP signaling links metabolism, DNA repair, and responses to genotoxic stress, Weihua Zhou, Zitong Zhao, Angelica Lin, John Yang, Jie Xu, Wilder-Romans Kari, Annabel Yang, Jing Li, Sumeet Solanki, Jennifer Speth, Natalie Walker, Andrew J. Scott, Ayesha U. Kothari, Yangyang Yao, Erik R. Peterson, Navyateja Korimerla, Christian K. Werner, Jessica Liang, Janna Jacobson, Sravya Palavalasa, Alexandra M. Obrien, Ameer L. Elaimy, Sean P. Ferris, Shuang G. Zhao, Jann N. Sarkaria, Balázs Győrffy, Shuqun Zhang, Wajd N. Al-Holou, Yoshie Umemura, Meredith A. Morgan, Theodore S. Lawrence, and Costas A. Lyssiotis

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Benchmarking Hospital Practices and Policies on Intrahospital Neurocritical Care Transport: The Safe-Neuro-Transport Study, Kapil G. Zirpe, Bhunyawee Alunpipatthanachai, Nassim Matin, Bernice G. Gulek, Patricia A. Blissitt, Katherine Palmieri, Kathryn Rosenblatt, Umeshkumar Athiraman, Suneeta Gollapudy, Marie Angele Theard, Sarah Wahlster, Monica S. Vavilala, Abhijit V. Lele, and Safe-Neuro-Transport Collaborators

Submissions from 2022

Electrodiagnosis of Guillain-Barre syndrome in the International GBS Outcome Study: Differences in methods and reference values., Samuel Arends, Judith Drenthen, Peter van den Bergh, Hessel Franssen, Robert D M Hadden, Badrul Islam, Satoshi Kuwabara, Ricardo C Reisin, Nortina Shahrizaila, Hiroshi Amino, Giovanni Antonini, Shahram Attarian, Claudia Balducci, Fabio Barroso, Tulio Bertorini, Davide Binda, Thomas H Brannagan, Jan Buermann, Carlos Casasnovas, Guido Cavaletti, Chi-Chao Chao, Mazen M Dimachkie, Ernesto A Fulgenzi, Giuliana Galassi, Gerardo Gutiérrez Gutiérrez, Thomas Harbo, Hans-Peter Hartung, Sung-Tsang Hsieh, Lynette Kiers, Helmar C Lehmann, Fiore Manganelli, Girolama A Marfia, Giorgia Mataluni, Julio Pardo, Yann Péréon, Yusuf A Rajabally, Lucio Santoro, Yukari Sekiguchi, Beth Stein, Mark Stettner, Antonino Uncini, Christine Verboon, Camiel Verhamme, Michal Vytopil, Waqar Waheed, Min Wang, Sasha Zivkovic, Bart C Jacobs, David R Cornblath, and Shafeeq S. Ladha

Emotional Resilience Predicts Preserved White Matter Microstructure Following Mild Traumatic Brain Injury., Lanya T Cai, Benjamin L Brett, Eva M Palacios, Esther L Yuh, Ioanna Bourla, Jamie Wren-Jarvis, Yang Wang, Christine Mac Donald, Ramon Diaz-Arrastia, Joseph T Giacino, David O Okonkwo, Harvey S Levin, Claudia S Robertson, Nancy Temkin, Amy J Markowitz, Geoffrey T Manley, Murray B Stein, Michael A McCrea, Ross D Zafonte, Lindsay D Nelson, and Pratik Mukherjee

Incidence of Amyotrophic Lateral Sclerosis in Older Adults., Alejandra Camacho-Soto, Susan Searles Nielsen, Irene M Faust, Robert C Bucelli, Timothy M Miller, and Brad A Racette

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Liver Cirrhosis and Inpatient Mortality in Aneurysmal Subarachnoid Hemorrhage: A Propensity-Adjusted Analysis, Joshua S. Catapano, Katriel E. Lee, Kavelin Rumalla, Visish M. Srinivasan, Tyler S. Cole, Jacob F. Baranoski, Ethan A. Winkler, Christopher S. Graffeo, Muhaiman Alabdly, Ruchira M. Jha, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton

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Review of Advanced Drug Trials Focusing on the Reduction of Brain Beta-Amyloid to Prevent and Treat Dementia, Boris Decourt, Keith Noorda, Kevin Noorda, Jiong Shi, and Marwan N. Sabbagh

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The importance of genomics in advancing the diagnosis and treatment of dementia, Boris Decourt and Marwan N. Sabbagh

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Long-term Safety and Efficacy of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease, Mazen M. Dimachkie, Richard J. Barohn, Barry Byrne, Ozlem Goker-Alpan, Priya S. Kishnani, Shafeeq Ladha, Pascal Laforêt, Karl Eugen Mengel, Loren D. Peña, Sabrina Sacconi, Volker Straub, Jaya Trivedi, Philip Van Damme, Ans T. van der Ploeg, John Vissing, Peter Young, Kristina An Haack, Meredith Foster, Jane M. Gilbert, Patrick Miossec, Olivier Vitse, Tianyue Zhou, and Benedikt Schoser

Predicting Outcome in Guillain-Barré Syndrome: International Validation of the Modified Erasmus GBS Outcome Score., Alex Y Doets, Hester F Lingsma, Christa Walgaard, Badrul Islam, Nowshin Papri, Amy Davidson, Yuko Yamagishi, Susumu Kusunoki, Mazen M Dimachkie, Waqar Waheed, Noah Kolb, Zhahirul Islam, Quazi Deen Mohammad, Thomas Harbo, Soren H Sindrup, Govindsinh Chavada, Hugh J Willison, Carlos Casasnovas, Kathleen Bateman, James A L Miller, Bianca van den Berg, Christine Verboon, Joyce Roodbol, Sonja E Leonhard, Luana Benedetti, Satoshi Kuwabara, Peter Van den Bergh, Soledad Monges, Girolama A Marfia, Nortina Shahrizaila, Giuliana Galassi, Yann Péréon, Jan Bürmann, Krista Kuitwaard, Ruud P Kleyweg, Cintia Marchesoni, María J Sedano Tous, Luis Querol, Isabel Illa, Yuzhong Wang, Eduardo Nobile-Orazio, Simon Rinaldi, Angelo Schenone, Julio Pardo, Frederique H Vermeij, Helmar C Lehmann, Volkan Granit, Guido Cavaletti, Gerardo Gutiérrez-Gutiérrez, Fabio A Barroso, Leo H Visser, Hans D Katzberg, Efthimios Dardiotis, Shahram Attarian, Anneke J van der Kooi, Filip Eftimov, Paul W Wirtz, Johnny P A Samijn, H Jacobus Gilhuis, Robert D M Hadden, James K L Holt, Kazim A Sheikh, Summer Karafiath, Michal Vytopil, Giovanni Antonini, Thomas E Feasby, Catharina G Faber, Cees J Gijsbers, Mark Busby, Rhys C Roberts, Nicholas J Silvestri, Raffaella Fazio, Gert W van Dijk, Marcel P J Garssen, Chiara S M Straathof, Kenneth C Gorson, Bart C Jacobs, and Shafeeq S. Ladha

International Validation of the Erasmus Guillain-Barré Syndrome Respiratory Insufficiency Score., Alex Y Doets, Christa Walgaard, Hester F Lingsma, Badrul Islam, Nowshin Papri, Yuko Yamagishi, Susumu Kusunoki, Mazen M Dimachkie, Waqar Waheed, Noah Kolb, Kenneth C Gorson, Bart C Jacobs, and Shafeeq S. Ladha

Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation., Stefania Galimberti, Francesca Graziano, Andrew I R Maas, Giulia Isernia, Fiona Lecky, Sonia Jain, Xiaoying Sun, Raquel C Gardner, Sabrina R Taylor, Amy J Markowitz, Geoffrey T Manley, Maria Grazia Valsecchi, Giuseppe Bellelli, and Giuseppe Citerio

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Anatomical positional changes in the lateral lumbar interbody fusion, Shashank V. Gandhi, Robert Dugan, Samuel H. Farber, Jakub Godzik, Lea Alhilali, and Juan S. Uribe

Employment and Economic Outcomes of Participants With Mild Traumatic Brain Injury in the TRACK-TBI Study., Étienne Gaudette, Seth A Seabury, Nancy Temkin, Jason Barber, Anthony M DiGiorgio, Amy J Markowitz, and Geoffrey T Manley

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Monogenic Stroke-Can We Overcome Nature With Nurture?, Ruchira M. Jha

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Do We Need an ICU for All Elective Postcraniotomy Patients? A Critical Appraisal, Ruchira Menka Jha

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Validity of the Clinical Dementia Rating Scale Sum of Boxes in Staging and Detection of Cognitive Impairment in Mexican Americans, Parunyou Julayanont and John C. DeToledo

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Frontotemporal Dementia and the Sagging Brain, Parunyou Julayanont and Meredith Wicklund

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The Ophthalmology Surgical Competency Assessment Rubric (OSCAR) for Open Globe Surgical Management, Grant A. Justin, Mohammed Soleimani, Sidra Zafar, Kasra Cheraqpour, Catherine Green, Mohammad Moin, N Venkatesh Prajna, Karl C. Golnik, and Fasika A. Woreta

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Pharmacologic Mydriasis Secondary to Topical Glycopyrronium Tosylate Cloths: Clinical Characterization From a Multicenter Analysis, Aaron R. Kaufman, Shawn Gulati, John H. Pula, Timothy M. Janetos, Neena R. Cherayil, Eric Chiu, Emily Anne Shepherd, Karl C. Golnik, Enrique Garcia-Valenzuela, Peter W. MacIntosh, Brooke T. Johnson, and Kimberlee M. Curnyn

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Health Care Expenditures Associated with Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage: A Propensity-Adjusted Analysis, Stefan W. Koester, Joshua S. Catapano, Kavelin Rumalla, Stephen J. Dabrowski, Dimitri Benner, Ethan A. Winkler, Tyler S. Cole, Jacob F. Baranoski, Visish M. Srinivasan, Christopher S. Graffeo, Ruchira M. Jha, Ashutosh P. Jadhav, Andrew F. Ducruet, Felipe C. Albuquerque, and Michael T. Lawton

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CD11b B Cells Increase after Stroke and Regulate Microglia, Janelle M. Korf, Pedram Honarpisheh, Eric C. Mohan, Anik Banerjee, Maria P. Blasco-Conesa, Parisa Honarpisheh, Gary U. Guzman, Romeesa Khan, Bhanu P. Ganesh, Amy L. Hazen, Juneyoung Lee, Aditya Kumar, Louise D. McCullough, and Anjali Chauhan

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Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging, Janina Krell-Roesch, Martin Rakusa, Jeremy A. Syrjanen, Argonde C. van Harten, Val J. Lowe, Clifford R. Jack, Walter K. Kremers, David S. Knopman, Gorazd B. Stokin, Ronald C. Petersen, Maria Vassilaki, and Yonas E. Geda

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Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD, Gopinath Krishnan, Denitza Raitcheva, Daniel Bartlett, Mercedes Prudencio, Diane M. McKenna-Yasek, Catherine Douthwright, Björn E. Oskarsson, Shafeeq Ladha, Oliver D. King, Sami J. Barmada, Timothy M. Miller, Robert Bowser, Jonathan K. Watts, Leonard Petrucelli, Robert H. Brown, Mark W. Kankel, and Fen-Biao Gao

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Twenty Years of the Health Insurance Portability and Accountability Act Safe Harbor Provision: Unsolved Challenges and Ways Forward, Brittany Krzyzanowski and Steven M. Manson

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Dynamic susceptibility contrast and diffusion-weighted MRI in posterior fossa pilocytic astrocytoma and medulloblastoma, Ryo Kurokawa, Yoshie Umemura, Aristides Capizzano, Mariko Kurokawa, Akira Baba, Adam Holmes, John Kim, Yoshiaki Ota, Ashok Srinivasan, and Toshio Moritani

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Efficacy and toxicity with radiation field designs and concurrent temozolomide for CNS lymphoma, Anna M. Laucis, Katherine Selwa, Yilun Sun, Michelle M. Kim, Kyle C. Cuneo, Theodore S. Lawrence, Daniel R. Wahl, Larry Junck, and Yoshie Umemura

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Decreased DNA Methylation of RGMA is Associated with Intracranial Hypertension After Severe Traumatic Brain Injury: An Exploratory Epigenome-Wide Association Study, Dongjing Liu, Benjamin E. Zusman, John R. Shaffer, Yunqi Li, Annie I. Arockiaraj, Shuwei Liu, Daniel E. Weeks, Shashvat M. Desai, Patrick M. Kochanek, Ava M. Puccio, David O. Okonkwo, Yvette P. Conley, and Ruchira M. Jha

Outcomes in Patients With Mild Traumatic Brain Injury Without Acute Intracranial Traumatic Injury., Debbie Y Madhok, Robert M Rodriguez, Jason Barber, Nancy R Temkin, Amy J Markowitz, Natalie Kreitzer, and Geoffrey T Manley

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Brain-Lung Crosstalk: Management of Concomitant Severe Acute Brain Injury and Acute Respiratory Distress Syndrome, Nassim Matin, Kasra Sarhadi, C Patrick Crooks, Abhijit V. Lele, Vasisht Srinivasan, Nicholas J. Johnson, Chiara Robba, James A. Town, and Sarah Wahlster

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Neuropathologic validation of the Alzheimer's Questionnaire, Ida Mohebpour, Michael Malek-Ahmadi, Thomas Virden, Angela Breitmeyer, Marwan N. Sabbagh, Briana Auman, Christine M. Belden, Parichita Choudhury, Autumn Arch, Kathryn Davis, Carol Cline, Naudia Moorley, Alireza Atri, Geidy Serrano, and Thomas G. Beach

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Ophthalmology foundation Ophthalmic Surgical Competency Assessment Rubric (OSCAR) for pterygium surgery, Muhammad Moin, Karl C. Golnik, Sepehr Feizi, Agvaandorj Buyandelger, and Rosa E. Adrianzen

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Apathy as a Treatment Target in Alzheimer's Disease: Implications for Clinical Trials, Moyra E. Mortby, Lawrence Adler, Luis Agüera-Ortiz, Daniel R. Bateman, Henry Brodaty, Marc Cantillon, Yonas E. Geda, Zahinoor Ismail, Krista L. Lanctôt, Gad A. Marshall, Prasad R. Padala, Antonios Politis, Paul B. Rosenberg, Kostas Siarkos, David L. Sultzer, and Christos Theleritis

Between Scylla and Charybdis: risks of early therapeutic anticoagulation for venous thromboembolism after acute intracranial hemorrhage., Thuhien Nguyen, Monisha Sharma, Patrick Crooks, Pratik V Patel, Robert H Bonow, Claire J Creutzfeldt, and Sarah Wahlster

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Natural Pattern of Cognitive Aging, Jan S. Novotný, Juan P. Gonzalez-Rivas, Maria Vassilaki, Janina Krell-Roesch, Yonas E. Geda, and Gorazd B. Stokin

Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development., Sabrina Paganoni, James D Berry, Melanie Quintana, Eric Macklin, Benjamin R Saville, Michelle A Detry, Marianne Chase, Alexander V Sherman, Hong Yu, Kristin Drake, Jinsy Andrews, Jeremy Shefner, Lori B Chibnik, Matteo Vestrucci, Merit E Cudkowicz, and Shafeeq S. Ladha

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Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial, Sabrina Paganoni, Suzanne Hendrix, Samuel P. Dickson, Newman Knowlton, James D. Berry, Michael A. Elliott, Samuel Maiser, Chafic Karam, James B. Caress, Margaret Ayo Owegi, Adam Quick, James Wymer, Stephen A. Goutman, Daragh Heitzman, Terry D. Heiman-Patterson, Carlayne Jackson, Colin Quinn, Jeffrey D. Rothstein, Edward J. Kasarskis, Jonathan Katz, Liberty Jenkins, Shafeeq S. Ladha, Timothy M. Miller, Stephen N. Scelsa, Tuan H. Vu, Christina Fournier, Kristin M. Johnson, Andrea Swenson, Namita Goyal, Gary L. Pattee, Suma Babu, and Marianne Chase

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Environmental manganese exposure and cognitive control in a South African population, Brad A. Racette, Gill Nelson, Wendy W. Dlamini, Tamara Hershey, Pradeep Prathibha, Jay R. Turner, Harvey Checkoway, Lianne Sheppard, and Susan Searles Nielsen

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Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial, Michael S. Rafii, Olivier Sol, William C. Mobley, Saskia Delpretti, Brian G. Skotko, Anna D. Burke, Marwan N. Sabbagh, Shauna H. Yuan, Robert A. Rissman, Margaret Pulsifer, Casey Evans, A Carol Evans, Gregory Beth, Nicolas Fournier, Julian A. Gray, Antonio Melo Dos Santos, Valerie Hliva, Marija Vukicevic, Marie Kosco-Vilbois, Johannes Streffer, Andrea Pfeifer, and Howard H. Feldman

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Pearls & Oy-sters: Pivoting Treatment Regimens of Pediatric Atypical Teratoid Rhabdoid Tumors to Optimize Care in Adult ATRT: A Case Report, Rohan Rao, Abigail Koehler, Yehudit Rothman, Brandi Turner, Jamie Denlinger, Melissa Erickson, Matthew Hagen, Timothy S. Braverman, Abdelkader Mahammedi, Karl Golnik, Mario Zuccarello, Yair M. Gozal, E Randolph Broun, Susan N. Chi, and Soma Sengupta

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Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease, Ana Sofía Ríos, Simón Oxenford, Clemens Neudorfer, Konstantin Butenko, Ningfei Li, Nanditha Rajamani, Alexandre Boutet, Gavin J. Elias, Jurgen Germann, Aaron Loh, Wissam Deeb, Fuyixue Wang, Kawin Setsompop, Bryan Salvato, Leonardo Brito Almeida, Kelly D. Foote, Robert Amaral, Paul B. Rosenberg, David F. Tang-Wai, David A. Wolk, Anna D. Burke, Stephen Salloway, Marwan N. Sabbagh, M Mallar Chakravarty, Gwenn S. Smith, Constantine G. Lyketsos, Michael S. Okun, William S. Anderson, Zoltan Mari, Francisco A. Ponce, Andres M. Lozano, and Andreas Horn

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COR388 (atuzaginstat): an investigational gingipain inhibitor for the treatment of Alzheimer disease, Marwan N. Sabbagh and Boris Decourt

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Primary prevention recommendations to reduce the risk of cognitive decline, Marwan N. Sabbagh, Adriana Perez, Thomas M. Holland, Malaz Boustani, Stephanie R. Peabody, Kristine Yaffe, Michelle Bruno, Russell Paulsen, Kelly O'Brien, Naila Wahid, and Rudolph E. Tanzi

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Complete Response of a Patient With a Mismatch Repair Deficient Aggressive Pituitary Adenoma to Immune Checkpoint Inhibitor Therapy: A Case Report, Sanjit Shah, Saima Manzoor, Yehudit Rothman, Matthew Hagen, Luke Pater, Karl Golnik, Abdelkader Mahammedi, Andrew L. Lin, Ruchi Bhabhra, Jonathan A. Forbes, and Soma Sengupta

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Predictors of Time to Aneurysm Repair and Mortality in Aneurysmal Subarachnoid Hemorrhage, Tiffany O. Sheehan, Nicolle W. Davis, Yi Guo, Debra Lynch Kelly, Saunjoo L. Yoon, and Ann L. Horgas

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Liquid biopsy in gliomas: A RANO review and proposals for clinical applications, Riccardo Soffietti, Chetan Bettegowda, Ingo K. Mellinghoff, Katherine E. Warren, Manmeet S. Ahluwalia, John F. De Groot, Evanthia Galanis, Mark R. Gilbert, Kurt A. Jaeckle, Emilie Le Rhun, Roberta Rudà, Joan Seoane, Niklas Thon, Yoshie Umemura, Michael Weller, Martin J. van den Bent, Michael A. Vogelbaum, Susan M. Chang, and Patrick Y. Wen

Risk Factors for High Symptom Burden Three Months after Traumatic Brain Injury and Implications for Clinical Trial Design: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study., Nancy Temkin, Joan Machamer, Sureyya Dikmen, Lindsay D Nelson, Jason Barber, Phillip H Hwang, Kim Boase, Murray B Stein, Xiaoying Sun, Joseph Giacino, Michael A McCrea, Sabrina R Taylor, Sonia Jain, and Geoff Manley

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Increased creativity associated with dopamine agonist therapy: A case report and short review of the literature, Smathorn Thakolwiboon, Amputch Karukote, Parunyou Julayanont, and Henrik Wilms

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Discordance Between Perceptions and Experience of Lumbar Puncture: A Prospective Study, Yoshie Umemura, Baber Khan, Benjamin J. Weill, Justin J. Buthorn, Anna Skakodub, Andrew J. Ridder, Kathryn S. Nevel, Yilun Sun, and Adrienne Boire

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Association of neighborhood socioeconomic disadvantage and cognitive impairment, Maria Vassilaki, Jeremiah A. Aakre, Anna Castillo, Alanna M. Chamberlain, Patrick M. Wilson, Walter K. Kremers, Michelle M. Mielke, Yonas E. Geda, Mary M. Machulda, Rabe E. Alhurani, Jonathan Graff-Radford, Prashanthi Vemuri, Val J. Lowe, Clifford R. Jack, David S. Knopman, and Ronald C. Petersen

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Association of Performance on the Financial Capacity Instrument-Short Form With Brain Amyloid Load and Cortical Thickness in Older Adults, Maria Vassilaki, Jeremiah A. Aakre, Walter K. Kremers, Michelle M. Mielke, Yonas E. Geda, Mary M. Machulda, David S. Knopman, Prashanthi Vemuri, Val J. Lowe, Clifford R. Jack, Erik D. Roberson, Adam Gerstenecker, Roy C. Martin, Richard E. Kennedy, Daniel C. Marson, and Ronald C. Petersen

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Feasibility and preliminary effects of exercise interventions on plasma biomarkers of Alzheimer's disease in the FIT-AD trial: a randomized pilot study in older adults with Alzheimer's dementia, Fang Yu, Seung Yong Han, Dereck Salisbury, Jeremy J. Pruzin, Yonas Geda, Richard J. Caselli, and Danni Li

Submissions from 2021

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Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project, Michael L. Alosco, Megan L. Mariani, Charles H. Adler, Laura J. Balcer, Charles Bernick, Rhoda Au, Sarah J. Banks, William B. Barr, Sylvain Bouix, Robert C. Cantu, Michael J. Coleman, David W. Dodick, Lindsay A. Farrer, Yonas E. Geda, Douglas I. Katz, Inga K. Koerte, Neil W. Kowall, Alexander P. Lin, Daniel S. Marcus, Kenneth L. Marek, Michael D. McClean, Ann C. McKee, Jesse Mez, Joseph N. Palmisano, Elaine R. Peskind, Yorghos Tripodis, Robert W. Turner, Jennifer V. Wethe, Jeffrey L. Cummings, Eric M. Reiman, Martha E. Shenton, and Robert A. Stern

Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS): Bayesian Adaptive Comparative Effectiveness Randomized Trial, Richard J. Barohn, Byron Gajewski, Mamatha Pasnoor, Alexandra Brown, Laura L. Herbelin, Kim S. Kimminau, Dinesh Pal Mudaranthakam, Omar Jawdat, Mazen M. Dimachkie, Stanley Iyadurai, Amro Stino, John Kissel, Robert Pascuzzi, Thomas Brannagan, Matthew Wicklund, Aiesha Ahmed, David Walk, Gordon Smith, Dianna Quan, Darryl Heitzman, Alejandro Tobon, Shafeeq Ladha, Gil Wolfe, Michael Pulley, Ghazala Hayat, Yuebing Li, Pariwat Thaisetthawatkul, Richard Lewis, Suur Biliciler, Khema Sharma, and Kian Salajegheh

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Potential Neuroregenerative and Neuroprotective Effects of Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment: A Narrative Review, Barry S. Baumel, P. Murali Doraiswamy, Marwan Sabbagh, and Richard Wurtman

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Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial, Daniel K. Burns, Robert C. Alexander, Kathleen A. Welsh-Bohmer, Meredith Culp, Carl Chiang, Janet O'Neil, Rebecca M. Evans, Patrick Harrigan, Brenda L. Plassman, James R. Burke, Jingtao Wu, Michael W. Lutz, Stephen Haneline, Adam J. Schwarz, Lon S. Schneider, Kristine Yaffe, Ann M. Saunders, Emiliangelo Ratti, Dag Aarsland, Oda Ackermann, Joscelyn Agron-Figueroa, Thomas Arnold, Peter Bailey, Clive Ballard, Scott Barton, Christine Belden, James Bergthold, Wendy Bond, Ronald Bradley, Walter Braude, Mark Brody, and Richard Brown

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Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study, Shi Dong Chen, Jia Ying Lu, Hong Qi Li, Yu Xiang Yang, Jie Hui Jiang, Mei Cui, Chuan Tao Zuo, Lan Tan, Qiang Dong, Jin Tai Yu, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, Maria Carrillo, William Potter, Lisa Barnes, Marie Bernard, Hector González, Carole Ho, John K. Hsiao, Jonathan Jackson, and Eliezer Masliah

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Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization, Yeonwoo Chung, Hyunju Lee, Michael W. Weiner, Paul Aisen, Ronald Petersen, Cliford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, and Tamie Sather

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Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications, Andrea Comba, Syed M. Faisal, Maria Luisa Varela, Todd Hollon, Wajd N. Al-Holou, Yoshie Umemura, Felipe J. Nunez, Sebastien Motsch, Maria G. Castro, and Pedro R. Lowenstein

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Pharmacoresistant seizures and IDH mutation in low-grade gliomas, Carlos Eduardo Correia, Yoshie Umemura, Jessica R. Flynn, Anne S. Reiner, and Edward K. Avila

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Principal Component Analysis of Striatal and Extrastriatal D2 Dopamine Receptor Positron Emission Tomography in Manganese-Exposed Workers, Susan R. Criswell, Susan Searles Nielsen, Wendy W. Dlamini, Mark N. Warden, Joel S. Perlmutter, Lianne Sheppard, Stephen M. Moerlein, Jason Lenox-Krug, Harvey Checkoway, and Brad A. Racette

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Aducanumab produced a clinically meaningful benefit in association with amyloid lowering, Jeffrey Cummings, Paul Aisen, Cynthia Lemere, Alireza Atri, Marwan Sabbagh, and Stephen Salloway