The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.
Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.
Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.
Submissions from 2003
Effects of donepezil treatment on rat nicotinic acetylcholine receptor levels in vivo and in vitro, Richard T. Reida and Marwan N. Sabbagh
Length of stay in skilled nursing facilities is longer for patients with dementia, Marwan N. Sabbagh, Nina Silverberg, Bashar Majeed, Shefali Samant, D. Larry Sparks, James Seward, and Donald J. Connor
A Position Paper: Based on Observational Data Indicating an Increased Rate of Altered Blood Chemistry Requiring Withdrawal from the Alzheimer's Disease Cholesterol-Lowering Treatment Trial (ADCLT), D. Larry Sparks, Jean Lopez, Don Connor, Marwan Sabbagh, Jim Seward, and Patrick Browne
Is cholesterol a culprit in Alzheimer's disease?, D. Larry Sparks, Marwan N. Sabbagh, John C.S. Breitner, and John C. Hunsaker
Comparison of the Short Test of Mental Status and the Mini-Mental State Examination in Mild Cognitive Impairment, David F. Tang-Wai, David S. Knopman, Yonas E. Geda, Steven D. Edland, Glenn E. Smith, Robert J. Ivnik, Eric G. Tangalos, Bradley F. Boeve, and Ronald C. Petersen
A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease, George S. Zubenko, Wendy N. Zubenko, Susan McPherson, Eleanor Spoor, Deborah B. Marin, Martin R. Farlow, Glenn E. Smith, Yonas E. Geda, Jeffrey L. Cummings, Ronald C. Petersen, and Trey Sunderland
Submissions from 2002
Progressive aphasia with Lewy bodies, Richard J. Caselli, Thomas G. Beach, Lucia I. Sue, Donald J. Connor, and Marwan N. Sabbagh
Prognosis of ischemic internuclear ophthalmoplegia, Eric Eggenberger, Karl Golnik, Andrew Lee, Ronel Santos, Analyn Suntay, Banu Satana, Michael Vaphlades, Charles Stevens, David Kaufman, Michael Wall, and Randy Kardon
Infectious optic neuropathy, Karl C. Golnik
Epilepsy after brain insult: Targeting epileptogenesis, Susan T. Herman
Intravenous recombinant tissue-type plasminogen activator thrombolysis in treatment of central retinal artery occlusion, Jorge C. Kattah, David Z. Wang, and Chittaranjan Reddy
The quantitative evaluation of functional neuroimaging experiments: Mutual information learning curves, U. Kjems, L. K. Hansen, J. Anderson, S. Frutiger, S. Muley, J. Sidtis, D. Rottenberg, and S. C. Strother
Phenotypic variability leads to under-recognition of HNPP, Neeraj Kumar, Suraj Muley, Anthony Pakiam, and Gareth J. Parry
Delirium resulting from paraneoplastic limbic encephalitis caused by Hodgkin's disease, Simon Kung, Paul S. Mueller, Yonas E. Geda, and Lois E. Krahn
MRI in isolated sixth nerve palsies, A G. Lee, E Eggenberger, K Golnik, and N R. Miller
Sleep apnea and intracranial hypertension in men, Andrew G. Lee, Karl Golnik, Randy Kardon, Michael Wall, Eric Eggenberger, and Sunita Yedavally
Parkinson's disease and apolipoprotein E: possible association with dementia but not age at onset., Abbas Parsian, Brad Racette, L Jane Goldsmith, and Joel S Perlmutter
Ptosis as a remote effect of therapeutic botulinum toxin B injection, B A. Racette, G Lopate, L Good, S Sagitto, and J S. Perlmutter
A multi-incident, Old-Order Amish family with PD, B A. Racette, M Rundle, J C. Wang, A Goate, N L. Saccone, M Farrer, S Lincoln, J Hussey, S Smemo, J Lin, B Suarez, A Parsian, and J S. Perlmutter
Clinical features and comorbidity of mood fluctuations in Parkinson's disease, Brad A. Racette, Johanna M. Hartlein, Tamara Hershey, Jonathan W. Mink, Joel S. Perlmutter, and Kevin J. Black
Secondary nonresponsiveness to new bulk botulinum toxin A (BCB2024), Brad A. Racette, Mikula Stambuk, and Joel S. Perlmutter
Respiratory Complications of Parkinson's Disease, Holly A. Shill and Mark Stacy
HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advise to use one that crosses the blood-brain barrier, D. L. Sparks, D. J. Connor, P. J. Browne, J. E. Lopez, and M. N. Sabbagh
Should the guidelines for monitoring serum cholesterol levels in the elderly be re-evaluated?, D. L. Sparks, D. J. Connor, P. Browne, and M. N. Sabbagh
Sun, moon, and stars, Kelly M. Vitousek and Jennifer Gray
Submissions from 2001
Intra-Arterial Cisplatin Plus Oral Etoposide for the Treatment of Recurrent Malignant Glioma: A Phase II Study, Lynn S. Ashby and W. R. Shapiro
Polka music and semantic dementia, Bradley F. Boeve and Yonas E. Geda
Assessment of Silent Embolism From Carotid Endarterectomy by Use of Diffusion-Weighted Imaging: Work in Progress, K. P.N. Forbes, Holly A. Shill, P. M. Britt, Joseph M. Zabramski, R. F. Spetzler, and J. E. Heiserman
Symptomatic corneal topographic change induced by reading in downgaze, K C. Golnik and E Eggenberger
Distribution of partial seizures during the sleep-wake cycle: Differences by seizure onset site, Susan T. Herman, T. S. Walczak, and C. W. Bazil
Intrathecal Treatment of Neoplastic Meningitis due to Breast Cancer With a Slow-Release Formulation of Cytarabine, K. A. Jaeckle, Surasak Phuphanich, M. J. van den Bent, R. Aiken, T. Batchelor, T. Campbell, D. Fulton, M. Gilbert, D. Heros, L. Rogers, S. J. O'Day, W. Akerley, J. Allen, S. Baidas, S. Z. Gertler, H. S. Greenberg, S. LaFollette, G. Lesser, W. Mason, and et al.
Movement Disorders and Normal Aging, Padma R. Mahant and Mark A. Stacy
Effects of changes in experimental design on PET studies of isometric force, Suraj A. Muley, Stephen C. Strother, James Ashe, Sally A. Frutiger, John R. Anderson, John J. Sidtis, and David A. Rottenberg
Thalamic stimulation for primary writing tremor, B A. Racette, J Dowling, J Randle, and J W. Mink
Welding-related parkinsonism: clinical features, treatment, and pathophysiology, B A. Racette, L McGee-Minnich, S M. Moerlein, J W. Mink, T O. Videen, and J S. Perlmutter
Late-onset neurodegeneration with brain iron accumulation type 1: expanding the clinical spectrum, B A. Racette, A Perry, G D'Avossa, and J S. Perlmutter
Does apolipoprotein E (Apo-E) genotype influence nicotinic receptor binding in Alzheimer's disease, R. T. Reid, M. N. Sabbagh, and L. J. Thal
Correlation of nicotinic receptor binding with clinical and neuropathological changes in Alzheimer's disease and dementia with Lewy bodies, M. N. Sabbagh, R. T. Reid, L. A. Hansen, M. Alford, and L. J. Thal
Dizziness and Headache: A Common Association in Children and Adolescents, Pedro Weisleder and Terry D. Fife
Submissions from 2000
Incidence of Postangiographic Abnormalities Revealed by Diffusion- Weighted MR Imaging, Peter M. Britt, Joseph E. Heiserman, Robb M. Snider, Holly A. Shill, C. R. Bird, and Robert C. Wallace
E4 allele dosage does not predict cholinergic activity or synapse loss in Alzheimer's disease, Jody Corey-Bloom, P. Tiraboschi, L. A. Hansen, M. Alford, B. Schoos, M. N. Sabbagh, E. Masliah, and L. J. Thal
Incidence of ocular misalignment and diplopia after uneventful cataract surgery, K C. Golnik, C E. West, E Kaye, K T. Corcoran, and R J. Cionni
Atypical features prompting neuroimaging in acute optic neuropathy in adults, A G. Lee, D J. Lin, M Kaufman, K C. Golnik, M S. Vaphiades, and E Eggenberger
Treatment of optic nerve sheath meningioma with three-dimensional conformal radiation, P D. Moyer, K C. Golnik, and J Breneman
Ipsilateral thalamic stimulation after thalamotomy for essential tremor. A case report, B A. Racette, K M. Rich, J Randle, and J W. Mink
Nicotinic receptor losses in dementia with Lewy bodies: Comparisons with Alzheimer's disease, Richard T. Reid, Marwan N. Sabbagh, Jody CoreyBloom, Pietro Tiraboschi, and Leon J. Thal
Chorea and jaw-opening dystonia as a manifestation of NeuroBehcet's syndrome, F J. Revilla, B A. Racette, and J S. Perlmutter
Amyloid-β and treatment opportunities for Alzheimer's disease, Marwan N. Sabbagh, Douglas Galasko, Edward Koo, and Leon J. Thal
Amyloid-beta and treatment opportunities for Alzheimer's disease, M N. Sabbagh, D Galasko, E Koo, and L J. Thal
A novel RGD-independent fibronectin assembly pathway initiated by alpha4beta1 integrin binding to the alternatively spliced V region., J L Sechler, A M Cumiskey, D M Gazzola, and J E Schwarzbauer
Valproic Acid Toxicity Mimicking Multiple System Atrophy, Holly A. Shill and Terry D. Fife
The quantitative evaluation of functional neuroimaging experiments: The NPAIRS data analysis framework, Stephen Strother, Jon Anderson, Sally Frutiger, Suraj Muley, David Rottenberg, Ulrik Kjems, and Lars Kai Hansen
Cholinergic dysfunction in diseases with LEWY bodies, P. Tiraboschi, L. A. Hansen, M. Alford, M. N. Sabbagh, B. Schoos, E. Masliah, L. J. Thal, and Jody Corey-Bloom
Treating acute stroke patients with intravenous tPA. The OSF stroke network experience, D Z. Wang, J A. Rose, D S. Honings, D J. Garwacki, and J C. Milbrandt
Submissions from 1999
Brain Tumors, Lynn S. Ashby, E. A. Obbens, and William R. Shapiro
Pathology of Intracranial Neoplasms, S. W. Coons and Lynn S. Ashby
Pain: Cause of agitation in elderly individuals with dementia [2], Y. E. Geda and T. A. Rummans
Visual loss in idiopathic intracranial hypertension after resolution of papilledema, K C. Golnik, T M. Devoto, R C. Kersten, and D Kulwin
An ice test for the diagnosis of myasthenia gravis, K C. Golnik, R Pena, A G. Lee, and E R. Eggenberger
Adolf Hitler's Cognitive Disorder and How it Affected His Conduct of World War II., Abraham N. Lieberman
Tissue expression and subcellular localization of CLN3, the Batten disease protein., L R Margraf, R L Boriack, A A Routheut, I Cuppen, L Alhilali, C J Bennett, and M J Bennett
Effect of changes in experimental design on patterns of brain activation during a static force paradigm: A PET study, Suraj Muley, James Ashe, Stephen Strother, John Anderson, Sally Frutiger, and David Rottenberg
Ophthalmoplegia associated with the anti-Ri antibody, R Ohmer, K C. Golnik, A I. Richards, and G S. Kosmorsky
Convergence insufficiency in idiopathic Parkinson's disease responsive to levodopa, B A. Racette, M S. Gokden, L S. Tychsen, and J S. Perlmutter
Efficacy and safety of a new bulk toxin of botulinum toxin in cervical dystonia: a blinded evaluation, B A. Racette, L McGee-Minnich, and J S. Perlmutter
Evaluation of a screening questionnaire for genetic studies of Parkinson's disease, B A. Racette, M Rundle, A Parsian, and J S. Perlmutter
Neurochemical markers do not correlate with cognitive decline in the Lewy body variant of Alzheimer disease, M N. Sabbagh, J Corey-Bloom, P Tiraboschi, R Thomas, E Masliah, and L J. Thal
Type 1 protease resistant prion protein and valine homozygosity at codon 129 of PRNP identify a subtype of sporadic Creutzfeldt-Jakob disease, Bradford B. Worrall, Susan T. Herman, Sabina Capellari, Timothy Lynch, Steven Chin, Pierluigi Gambetti, and Piero Parchi
Submissions from 1998
Preventing contractures [correction of contractions] in neuroleptic malignant syndrome and dystonia., K J Black, B Racette, and J S Perlmutter
Recognition and Management of Horizontal Canal Benign Positional Vertigo, Terry D. Fife
Congenital optic nerve anomalies, K C. Golnik
Optic nerve head swelling in the Hadju-Cheney syndrome, K C. Golnik and R C. Kersten
New options for the treatment of epilepsy, Susan T. Herman and Timothy A. Pedley
Gene-Toxin Interaction as a Putative Risk Factor for Parkinson's Disease With Dementia, J. P. Hubble, J. H. Kurth, S. L. Glatt, M. C. Kurth, G. D. Schellenberg, R. E. Hassanein, Abraham N. Lieberman, and W. C. Koller
Safety of Intrastriatal Neurotransplantation for Huntington's Disease Patients, O. V. Kopyov, S. Jacques, Abraham N. Lieberman, C. M. Duma, and K. S. Eagle
Impotence in Parkinson's Disease, Abraham N. Lieberman
Managing the Neuropsychiatric Symptoms of Parkinson's Disease, Abraham N. Lieberman
A Multicenter Trial of Ropinirole as Adjunct Treatment for Parkinson's Disease, Abraham N. Lieberman, C. W. Olanow, K. Sethi, P. Swanson, C. H. Waters, S. Fahn, H. Hurtig, and M. Yahr
Neuropathy in erythropoietic protoporphyrias, S. A. Muley, H. A. Midani, J. M. Rank, R. Carithers, and Gareth J. Parry
Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease., A Parsian, B Racette, Z H Zhang, S Chakraverty, M Rundle, A Goate, and J S Perlmutter
Preoperative treatment with botulinum toxin to facilitate cervical fusion in dystonic cerebral palsy. Report of two cases., B A Racette, C Lauryssen, and J S Perlmutter
Preoperative treatment with botulinum toxin to facilitate cervical fusion in dystonic cerebral palsy. Report of two cases, B A. Racette, C Lauryssen, and J S. Perlmutter
Levodopa responsive parkinsonism in an adult with Huntington's disease, B A. Racette and J S. Perlmutter
Correlation of nicotinic binding with neurochemical markers in Alzheimer's disease, M. N. Sabbagh, R. T. Reid, J. Corey-Bloom, T. S. Rao, L. A. Hansen, M. Alford, E. Masliah, A. Adem, G. K. Lloyd, and L. J. Thal
Pseudoneurologic syndromes: recognition and diagnosis, A Shaibani and M N. Sabbagh
Respiratory Function in Parkinson's Disease, Holly A. Shill and Mark Stacy
Submissions from 1997
Hippocampal sclerosis contributes to dementia in the elderly, J. Corey-Bloom, M. N. Sabbagh, M. W. Bondi, L. Hansen, M. F. Alford, E. Masliah, and L. J. Thal
Outcome Following Intrastriatal Fetal Mesencephalic Grafts for Parkinson's Patients is Directly Related to the Volume of Grafted Tissue, Oleg V. Kopyov, Deane Skip Jacques, Abraham N. Lieberman, Christopher M. Duma, and Robert L. Rogers
Types of cerebrovascular lesions associated with severe cerebral amyloid angiopathy in Alzheimer's disease, J M. Olichney, R J. Ellis, R Katzman, M N. Sabbagh, and L Hansen
The impact of apolipoprotein E4 on cause of death in Alzheimer's disease, J. M. Olichney, M. N. Sabbagh, C. R. Hofstetter, D. Galasko, M. Grundman, R. Katzman, and L. J. Thal
Correlations between SPECT regional cerebral blood flow and psychometric testing in patients with Alzheimer's disease, Marwan N. Sabbagh, Peggy Lynn, Satish Jhingran, Paul Massman, Javier Villanueva-Meyer, Jennifer Olup, and Rachelle S. Doody
Submissions from 1996
Magnetic resonance imaging in patients with unexplained optic neuropathy, K C. Golnik, P W. Hund, G A. Stroman, and W C. Stewart
Multicenter Placebo-Controlled Trial of Cabergoline Taken Once Daily in the Treatment of Parkinson's Disease, J. T. Hutton, W. C. Koller, J. E. Ahlskog, R. Pahwa, H. I. Hurtig, M. B. Stern, B. C. Hiner, Abraham N. Lieberman, R. F. Pfeiffer, R. L. Rodnitzky, C. H. Waters, M. D. Muenter, C. H. Adler, and J. L. Morris
Prevalence of Tremor and Parkinson's Disease, Avinash S. Khatter, Matthias C. Kurth, Melanie A. Brewer, Charles T. Crinnian, Joseph F. Drazkowski, Steven S. Flitman, Susan Imke, Sidney A. Spector, Kevin L. Wood, and Abraham N. Lieberman
Gender influences the magnitude of the inflammatory response within embolic cerebral infarcts in young rats, K Li, N Futrell, S Tovar, L C. Wang, D Z. Wang, and L R. Schultz
Pneumosinus dilatans: a sign of intracranial meningioma, N R. Miller, K C. Golnik, S M. Zeidman, and R B. North
Submissions from 1995
Novel Heuristics of Functional Neural Networks: Implications for Future Strategies in Functional Neurosurgery, Konstantin V. Baev, Karl A. Greene, Frederick F. Marciano, Andrew G. Shelter, Abraham N. Lieberman, and Robert F. Spetzler
Atonic pupil after cataract surgery, K C. Golnik, P W. Hund, and D J. Apple
Transient Resolution of Bilateral Tremor After Unilateral Thalamotomy Associated With Focal Injury of the Corpus Callosum: Case Report, Karl A. Greene, Robert C. Wallace, Evan K. Fram, Andrew G. Shetter, and Abraham N. Lieberman
Thoracoscopic thymectomy in patients with myasthenia gravis, M N. Sabbagh, J S. Garza, and B Patten