The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.
Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.
Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.
Submissions from 2005
Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD, D. Larry Sparks, Marwan N. Sabbagh, Donald J. Connor, Jean Lopez, Lenore J. Launer, Suzana Petanceska, Patrick Browne, Dawn Wassar, Sherry Johnson-Traver, Jeff Lochhead, and Chuck Ziolkowski
Submissions from 2004
A case of ischemic cerebral infarction associated with acute posterior multifocal placoid pigment epitheliopathy, CNS vasculitis, vitamin B(12) deficiency and homocysteinemia, Ammar Al Kawi, David Z. Wang, Kamal Kishore, and Jorge C. Kattah
Balint syndrome due to Creutzfeldt-Jakob disease, Beau M. Ances, J. M. Ellenbogen, S. T. Herman, D. Jacobs, D. S. Liebeskind, A. Chatterjee, and S. L. Galetta
Neurosyphilis and status epilepticus: Case report and literature review, Beau M. Ances, Renee Shellhaus, Mark J. Brown, O. Vanessa Rios, Susan T. Herman, and Jacqueline A. French
Low-Grade Glioma: Supratentorial Astrocytoma Oligodendroglioma and Oligoastrocytoma in Adults, Lynn S. Ashby and William R. Shapiro
Missed insulin meal boluses and elevated hemoglobin A1c levels in children receiving insulin pump therapy., Jonathan Burdick, H Peter Chase, Robert H Slover, Kerry Knievel, Laura Scrimgeour, Aristides K Maniatis, and Georgeanna J Klingensmith
Sensitivity to Expectancy Violations in Healthy Aging and Mild Cognitive Impairment, Juliet E. Davie, Tamiko Azuma, Stephen D. Goldinger, Donald J. Connor, Marwan N. Sabbagh, and Nina B. Silverberg
De novo genesis of neuropsychiatric symptoms in Mild Cognitive Impairment (MCI), Yonas E. Geda, Glenn E. Smith, David S. Knopman, Bradley F. Boeve, Eric G. Tongalos, Robert J. Ivnik, David A. Mrazek, Steven D. Edland, and Ronald C. Petersen
Neuro-ophthalmologic manifestations of systemic disease: rheumatologic/Inflammatory, Karl C. Golnik
The Ophthalmic Clinical Evaluation Exercise (OCEX), Karl C. Golnik, Linda M. Goldenhar, John W. Gittinger, and Jay M. Lustbader
The monocular vertical prism dissociation test, Karl C. Golnik, Andrew G. Lee, and Eric R. Eggenberger
Single unprovoked seizures, Susan T. Herman
Hippocampal adaptation to face repetition in healthy elderly and mild cognitive impairment, Sterling C. Johnson, Leslie C. Baxter, Lana Susskind-Wilder, Donald J. Connor, Marwan N. Sabbagh, and Richard J. Caselli
Argatroban anticoagulation in patients with acute ischemic stroke (ARGIS-1): a randomized, placebo-controlled safety study, Marian P. LaMonte, Marshall L. Nash, David Z. Wang, Andrew R. Woolfenden, John Schultz, Marcie J. Hursting, and Philip M. Brown
Regional Cerebral Blood Flow Correlates of the Severity of Writer's Cramp Symptoms, Alicja Lerner, Holly A. Shill, Takashi Hanakawa, Khalaf Bushara, Andrew Goldfine, and Mark Hallett
Isolated gait ataxia due to cerebellar vermis infarct, Suraj Ashok Muley and Khalafalla O. Bushara
Association of a variation in the promoter region of the brain-derived neurotrophic factor gene with familial Parkinson's disease., Abbas Parsian, Rashmi Sinha, Brad Racette, Jing H Zhao, and Joel S Perlmutter
Association of variations in monoamine oxidases A and B with Parkinson's disease subgroups., A Parsian, B Racette, Z H Zhang, M Rundle, and J S Perlmutter
Novel haplotypes in 17q21 are associated with progressive supranuclear palsy, Pau Pastor, Mario Ezquerra, J Christian Perez, Sumi Chakraverty, Joanne Norton, Brad A. Racette, Dan McKeel, Joel S. Perlmutter, Eduardo Tolosa, and Alison M. Goate
Teaching Motivational Interviewing to First-Year Medical Students to Improve Counseling Skills in Health Behavior Change, Maria K. Poirier, Matthew M. Clark, Jane H. Cerhan, Sandhya Pruthi, Yonas E. Geda, and Lowell C. Dale
Mapping of Sudden Infant Death With Dysgenesis of the Testes Syndrome (SIDDT) by a SNP Genome Scan and Identification of TSPYL Loss of Function, Erik G. Puffenberger, Diane Hu-Lince, Jennifer M. Parod, David W. Craig, Seth E. Dobrin, Andrew R. Conway, Elizabeth A. Donarum, Kevin A. Strauss, Travis Dunckley, Javier F. Cardenas, Kara R. Melmed, Courtney A. Wright, Winnie Liang, Phillip Stafford, C. Robert Flynn, D. Holmes Morton, and Dietrich A. Stephan
Pathophysiology of parkinsonism due to hydrocephalus, B A. Racette, G J. Esper, J Antenor, K J. Black, A Burkey, S M. Moerlein, T O. Videen, V Kotagal, J G. Ojemann, and J S. Perlmutter
Case series of clinically probable dementia with lewy bodies in two Native Americans, Marwan N. Sabbagh, Nina B. Silverberg, Douglas Walker, Donald J. Connor, James D. Seward, Ida P. Crocker-Sabbagh, Rochelle L. Descheny, Minnie Jim, and Leslie C. Baxter
Is there a characteristic lipid profile in Alzheimer's disease?, Marwan Sabbagh, H. Reza Zahiri, Joanne Ceimo, Kimbal Cooper, William Gaul, Donald Connor, and D. Larry Sparks
Omental infarct: an unusual CT appearance after superior mesenteric artery occlusion, Ajay K. Singh, Lea M. Alhilali, Debra A. Gervais, and Peter R. Mueller
Levodopa with carbidopa diminishes glycogen concentration, glycogen synthase activity, and insulin-stimulated glucose transport in rat skeletal muscle, Jill L. Smith, Jeong-Sun Ju, Bithika M. Saha, Brad A. Racette, and Jonathan S. Fisher
Alzheimer disease without neocortical neurofibrillary tangles: "A second look", P. Tiraboschi, M. N. Sabbagh, L. A. Hansen, D. P. Salmon, A. Merdes, A. Gamst, E. Masliah, M. Alford, L. J. Thal, and Jody Corey-Bloom
Treatment Options for Unruptured Cerebral Aneurysm, David Z. Wang, Huan Wang, Kenneth Fraser, and Giuseppe Lanzino
Rapid and selective cerebral hypothermia achieved using a cooling helmet., Huan Wang, William Olivero, Giuseppe Lanzino, William Elkins, Jean Rose, Debra Honings, Mary Rodde, Jan Burnham, and David Z. Wang
Submissions from 2003
Hippocampal sclerosis dementia with tauopathy, Thomas G. Beach, Lucia Sue, Sarah Scott, Kathryn Layne, Amanda Newell, Douglas Walker, Matthew Baker, Naraju Sahara, Shu Hui Yen, Michael Hutton, Richard Caselli, Charles Adler, Donald Connor, and Marwan Sabbagh
Abnormal corticomuscular coherence is associated with the small amplitude cortical myoclonus in Parkinson's disease, John N. Caviness, Charles H. Adler, Marwan N. Sabbagh, Donald J. Connor, Jose L. Hernandez, and Terrence D. Lagerlund
Dystonia in a patient with ring chromosome 21, Craig E. Hou, Bradley L. Schlaggar, and Brad A. Racette
A haplotype at the PARK3 locus influences onset age for Parkinson's disease: the GenePD study, S Karamohamed, A L. DeStefano, J B. Wilk, C M. Shoemaker, L I. Golbe, M H. Mark, A M. Lazzarini, O Suchowersky, N Labelle, M Guttman, L J. Currie, G F. Wooten, M Stacy, M Saint-Hilaire, R G. Feldman, K M. Sullivan, G Xu, R Watts, J Growdon, M Lew, C Waters, P Vieregge, P P. Pramstaller, C Klein, B A. Racette, J S. Perlmutter, A Parsian, C Singer, E Montgomery, K Baker, J F. Gusella, and S J. Fink
The evaluation of preprocessing choices in single-subject BOLD fMRI using NPAIRS performance metrics, Stephen LaConte, Jon Anderson, Suraj Muley, James Ashe, Sally Frutiger, Kelly Rehm, Lars Kai Hansen, Essa Yacoub, Xiaoping Hu, David Rottenberg, and Stephen Strother
Recurrent orthostatic numbness with carotid stenosis and beta-blocker use, Kamakshi Lakshminarayan, Stephen Holloway, and Suraj Muley
Discrete and Dynamic Scaling of the Size of Continuous Graphic Movements of Parkinsonian Patients and Elderly Controls, M. G. Longstaff, Padma R. Mahant, M. A. Stacy, A. W. Van Gemmert, B. C. Leis, and G. E. Stelmach
Autoimmune rippling muscle, Suraj Ashok Muley and John W. Day
Botulinum toxin B reduces sialorrhea in parkinsonism, Brad A. Racette, Laura Good, Sandy Sagitto, and Joel S. Perlmutter
Effects of donepezil treatment on rat nicotinic acetylcholine receptor levels in vivo and in vitro, Richard T. Reida and Marwan N. Sabbagh
Length of stay in skilled nursing facilities is longer for patients with dementia, Marwan N. Sabbagh, Nina Silverberg, Bashar Majeed, Shefali Samant, D. Larry Sparks, James Seward, and Donald J. Connor
A Position Paper: Based on Observational Data Indicating an Increased Rate of Altered Blood Chemistry Requiring Withdrawal from the Alzheimer's Disease Cholesterol-Lowering Treatment Trial (ADCLT), D. Larry Sparks, Jean Lopez, Don Connor, Marwan Sabbagh, Jim Seward, and Patrick Browne
Is cholesterol a culprit in Alzheimer's disease?, D. Larry Sparks, Marwan N. Sabbagh, John C.S. Breitner, and John C. Hunsaker
Comparison of the Short Test of Mental Status and the Mini-Mental State Examination in Mild Cognitive Impairment, David F. Tang-Wai, David S. Knopman, Yonas E. Geda, Steven D. Edland, Glenn E. Smith, Robert J. Ivnik, Eric G. Tangalos, Bradley F. Boeve, and Ronald C. Petersen
A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease, George S. Zubenko, Wendy N. Zubenko, Susan McPherson, Eleanor Spoor, Deborah B. Marin, Martin R. Farlow, Glenn E. Smith, Yonas E. Geda, Jeffrey L. Cummings, Ronald C. Petersen, and Trey Sunderland
Submissions from 2002
Progressive aphasia with Lewy bodies, Richard J. Caselli, Thomas G. Beach, Lucia I. Sue, Donald J. Connor, and Marwan N. Sabbagh
Prognosis of ischemic internuclear ophthalmoplegia, Eric Eggenberger, Karl Golnik, Andrew Lee, Ronel Santos, Analyn Suntay, Banu Satana, Michael Vaphlades, Charles Stevens, David Kaufman, Michael Wall, and Randy Kardon
Infectious optic neuropathy, Karl C. Golnik
Epilepsy after brain insult: Targeting epileptogenesis, Susan T. Herman
Intravenous recombinant tissue-type plasminogen activator thrombolysis in treatment of central retinal artery occlusion, Jorge C. Kattah, David Z. Wang, and Chittaranjan Reddy
The quantitative evaluation of functional neuroimaging experiments: Mutual information learning curves, U. Kjems, L. K. Hansen, J. Anderson, S. Frutiger, S. Muley, J. Sidtis, D. Rottenberg, and S. C. Strother
Phenotypic variability leads to under-recognition of HNPP, Neeraj Kumar, Suraj Muley, Anthony Pakiam, and Gareth J. Parry
Delirium resulting from paraneoplastic limbic encephalitis caused by Hodgkin's disease, Simon Kung, Paul S. Mueller, Yonas E. Geda, and Lois E. Krahn
MRI in isolated sixth nerve palsies, A G. Lee, E Eggenberger, K Golnik, and N R. Miller
Sleep apnea and intracranial hypertension in men, Andrew G. Lee, Karl Golnik, Randy Kardon, Michael Wall, Eric Eggenberger, and Sunita Yedavally
Parkinson's disease and apolipoprotein E: possible association with dementia but not age at onset., Abbas Parsian, Brad Racette, L Jane Goldsmith, and Joel S Perlmutter
Ptosis as a remote effect of therapeutic botulinum toxin B injection, B A. Racette, G Lopate, L Good, S Sagitto, and J S. Perlmutter
A multi-incident, Old-Order Amish family with PD, B A. Racette, M Rundle, J C. Wang, A Goate, N L. Saccone, M Farrer, S Lincoln, J Hussey, S Smemo, J Lin, B Suarez, A Parsian, and J S. Perlmutter
Clinical features and comorbidity of mood fluctuations in Parkinson's disease, Brad A. Racette, Johanna M. Hartlein, Tamara Hershey, Jonathan W. Mink, Joel S. Perlmutter, and Kevin J. Black
Secondary nonresponsiveness to new bulk botulinum toxin A (BCB2024), Brad A. Racette, Mikula Stambuk, and Joel S. Perlmutter
Respiratory Complications of Parkinson's Disease, Holly A. Shill and Mark Stacy
HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advise to use one that crosses the blood-brain barrier, D. L. Sparks, D. J. Connor, P. J. Browne, J. E. Lopez, and M. N. Sabbagh
Should the guidelines for monitoring serum cholesterol levels in the elderly be re-evaluated?, D. L. Sparks, D. J. Connor, P. Browne, and M. N. Sabbagh
Sun, moon, and stars, Kelly M. Vitousek and Jennifer Gray
Submissions from 2001
Intra-Arterial Cisplatin Plus Oral Etoposide for the Treatment of Recurrent Malignant Glioma: A Phase II Study, Lynn S. Ashby and W. R. Shapiro
Polka music and semantic dementia, Bradley F. Boeve and Yonas E. Geda
Assessment of Silent Embolism From Carotid Endarterectomy by Use of Diffusion-Weighted Imaging: Work in Progress, K. P.N. Forbes, Holly A. Shill, P. M. Britt, Joseph M. Zabramski, R. F. Spetzler, and J. E. Heiserman
Symptomatic corneal topographic change induced by reading in downgaze, K C. Golnik and E Eggenberger
Distribution of partial seizures during the sleep-wake cycle: Differences by seizure onset site, Susan T. Herman, T. S. Walczak, and C. W. Bazil
Intrathecal Treatment of Neoplastic Meningitis due to Breast Cancer With a Slow-Release Formulation of Cytarabine, K. A. Jaeckle, Surasak Phuphanich, M. J. van den Bent, R. Aiken, T. Batchelor, T. Campbell, D. Fulton, M. Gilbert, D. Heros, L. Rogers, S. J. O'Day, W. Akerley, J. Allen, S. Baidas, S. Z. Gertler, H. S. Greenberg, S. LaFollette, G. Lesser, W. Mason, and et al.
Movement Disorders and Normal Aging, Padma R. Mahant and Mark A. Stacy
Effects of changes in experimental design on PET studies of isometric force, Suraj A. Muley, Stephen C. Strother, James Ashe, Sally A. Frutiger, John R. Anderson, John J. Sidtis, and David A. Rottenberg
Thalamic stimulation for primary writing tremor, B A. Racette, J Dowling, J Randle, and J W. Mink
Welding-related parkinsonism: clinical features, treatment, and pathophysiology, B A. Racette, L McGee-Minnich, S M. Moerlein, J W. Mink, T O. Videen, and J S. Perlmutter
Late-onset neurodegeneration with brain iron accumulation type 1: expanding the clinical spectrum, B A. Racette, A Perry, G D'Avossa, and J S. Perlmutter
Does apolipoprotein E (Apo-E) genotype influence nicotinic receptor binding in Alzheimer's disease, R. T. Reid, M. N. Sabbagh, and L. J. Thal
Correlation of nicotinic receptor binding with clinical and neuropathological changes in Alzheimer's disease and dementia with Lewy bodies, M. N. Sabbagh, R. T. Reid, L. A. Hansen, M. Alford, and L. J. Thal
Dizziness and Headache: A Common Association in Children and Adolescents, Pedro Weisleder and Terry D. Fife
Submissions from 2000
Incidence of Postangiographic Abnormalities Revealed by Diffusion- Weighted MR Imaging, Peter M. Britt, Joseph E. Heiserman, Robb M. Snider, Holly A. Shill, C. R. Bird, and Robert C. Wallace
E4 allele dosage does not predict cholinergic activity or synapse loss in Alzheimer's disease, Jody Corey-Bloom, P. Tiraboschi, L. A. Hansen, M. Alford, B. Schoos, M. N. Sabbagh, E. Masliah, and L. J. Thal
Incidence of ocular misalignment and diplopia after uneventful cataract surgery, K C. Golnik, C E. West, E Kaye, K T. Corcoran, and R J. Cionni
Atypical features prompting neuroimaging in acute optic neuropathy in adults, A G. Lee, D J. Lin, M Kaufman, K C. Golnik, M S. Vaphiades, and E Eggenberger
Treatment of optic nerve sheath meningioma with three-dimensional conformal radiation, P D. Moyer, K C. Golnik, and J Breneman
Ipsilateral thalamic stimulation after thalamotomy for essential tremor. A case report, B A. Racette, K M. Rich, J Randle, and J W. Mink
Nicotinic receptor losses in dementia with Lewy bodies: Comparisons with Alzheimer's disease, Richard T. Reid, Marwan N. Sabbagh, Jody CoreyBloom, Pietro Tiraboschi, and Leon J. Thal
Chorea and jaw-opening dystonia as a manifestation of NeuroBehcet's syndrome, F J. Revilla, B A. Racette, and J S. Perlmutter
Amyloid-β and treatment opportunities for Alzheimer's disease, Marwan N. Sabbagh, Douglas Galasko, Edward Koo, and Leon J. Thal
Amyloid-beta and treatment opportunities for Alzheimer's disease, M N. Sabbagh, D Galasko, E Koo, and L J. Thal
A novel RGD-independent fibronectin assembly pathway initiated by alpha4beta1 integrin binding to the alternatively spliced V region., J L Sechler, A M Cumiskey, D M Gazzola, and J E Schwarzbauer
Valproic Acid Toxicity Mimicking Multiple System Atrophy, Holly A. Shill and Terry D. Fife
The quantitative evaluation of functional neuroimaging experiments: The NPAIRS data analysis framework, Stephen Strother, Jon Anderson, Sally Frutiger, Suraj Muley, David Rottenberg, Ulrik Kjems, and Lars Kai Hansen
Cholinergic dysfunction in diseases with LEWY bodies, P. Tiraboschi, L. A. Hansen, M. Alford, M. N. Sabbagh, B. Schoos, E. Masliah, L. J. Thal, and Jody Corey-Bloom
Treating acute stroke patients with intravenous tPA. The OSF stroke network experience, D Z. Wang, J A. Rose, D S. Honings, D J. Garwacki, and J C. Milbrandt
Submissions from 1999
Brain Tumors, Lynn S. Ashby, E. A. Obbens, and William R. Shapiro
Pathology of Intracranial Neoplasms, S. W. Coons and Lynn S. Ashby
Pain: Cause of agitation in elderly individuals with dementia [2], Y. E. Geda and T. A. Rummans
Visual loss in idiopathic intracranial hypertension after resolution of papilledema, K C. Golnik, T M. Devoto, R C. Kersten, and D Kulwin
An ice test for the diagnosis of myasthenia gravis, K C. Golnik, R Pena, A G. Lee, and E R. Eggenberger
Adolf Hitler's Cognitive Disorder and How it Affected His Conduct of World War II., Abraham N. Lieberman
Tissue expression and subcellular localization of CLN3, the Batten disease protein., L R Margraf, R L Boriack, A A Routheut, I Cuppen, L Alhilali, C J Bennett, and M J Bennett
Effect of changes in experimental design on patterns of brain activation during a static force paradigm: A PET study, Suraj Muley, James Ashe, Stephen Strother, John Anderson, Sally Frutiger, and David Rottenberg