Intravenous recombinant tissue plasminogen activator in a pregnant woman with cardioembolic stroke.

Authors

Kathleen M Wiese
Arun Talkad
Maureen Mathews
David Z. Wang, Neurovascular Division, Department of Neurology, Barrow Neurological Institute, St Joseph Hospital and Medical Center, Phoenix, AZ, USA.Follow

Document Type

Article

Abstract

BACKGROUND AND PURPOSE: Historically, the use of tissue plasminogen activator (tPA) thrombolysis in pregnancy has been regarded as relatively contraindicated. Underlying this stance has been the concern over the risk of bleeding complications in both mother and child.

SUMMARY OF CASE: We report the successful use of intravenous recombinant tPA (rtPA) thrombolysis in a pregnant woman with acute cardioembolic stroke.

CONCLUSIONS: The patient improved clinically, did not develop complications after receiving rtPA, and at 37 weeks' gestation, delivered a healthy infant, demonstrating that rtPA thrombolysis may be used safely in pregnant women.

Medical Subject Headings

Adult; Cesarean Section; Embolism; Female; Fibrinolytic Agents; Humans; Infant, Newborn; Injections, Intravenous; Live Birth; Male; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Trimester, Second; Recombinant Proteins; Stroke; Time Factors; Tissue Plasminogen Activator; Treatment Outcome

Publication Date

8-1-2006

Publication Title

Stroke; a journal of cerebral circulation

ISSN

1524-4628

Volume

37

Issue

8

First Page

2168

Last Page

2169

PubMed ID

16794210

Digital Object Identifier (DOI)

10.1161/01.STR.0000230286.95513.c2

Recommended Citation

Wiese, Kathleen M; Talkad, Arun; Mathews, Maureen; and Wang, David Z., "Intravenous recombinant tissue plasminogen activator in a pregnant woman with cardioembolic stroke." (2006). Neurology. 1849.
https://scholar.barrowneuro.org/neurology/1849