The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.
Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.
Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.
Submissions from 2006
Studies on the effect of the apolipoprotein E genotype on the lipid profile in Alzheimer's disease, Marwan N. Sabbagh, Shawn Sandhu, Heather Kolody, Tyson Lahti, Nina B. Silverberg, and D. Larry Sparks
Pathologic and nicotinic receptor binding differences between mild cognitive impairment, Alzheimer disease, and normal aging, Marwan N. Sabbagh, Flora Shah, Richard T. Reid, Lucia Sue, Donald J. Connor, Lars Kristofer N. Peterson, and Thomas G. Beach
Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay, Mark E. Shaneyfelt, Anna D. Burke, Joel W. Graff, Mark A. Jutila, and Michele E. Hardy
Imaging-guided catheter drainage of abdominal collections with fistulous pancreaticobiliary communication, Ajay K. Singh, Debra A. Gervais, Lea M. Alhilali, Peter F. Hahn, and Peter R. Mueller
Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: Results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial, D. L. Sparks, D. J. Connor, M. N. Sabbagh, R. B. Petersen, J. Lopez, and P. Browne
Statin therapy in Alzheimer's disease, D. L. Sparks, M. Sabbagh, D. Connor, H. Soares, J. Lopez, G. Stankovic, S. Johnson-Traver, C. Ziolkowski, and P. Browne
Perspectives on depression, mild cognitive impairment, and cognitive decline, David C. Steffens, Emeline Otey, George S. Alexopoulos, Meryl A. Butters, Bruce Cuthbert, Mary Ganguli, Yonas E. Geda, Hugh C. Hendrie, Ranga R. Krishnan, Anand Kumar, Oscar L. Lopez, Constantine G. Lyketsos, Benjamin T. Mast, John C. Morris, Maria C. Norton, Guerry M. Peavy, Ronald C. Petersen, Charles F. Reynolds, Stephen Salloway, Kathleen A. Welsh-Bohmer, and Jerome Yesavage
Influence of Heterozygosity for Parkin Mutation on Onset Age in Familial Parkinson Disease: The GenePD Study, Mei Sun, Jeanne C. Latourelle, G. Frederick Wooten, Mark F. Lew, and Christine Klein
Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment, Jon Valla, Lonnie Schneider, Tracy Niedzielko, Keith D. Coon, Richard Caselli, Marwan N. Sabbagh, Geoffrey L. Ahern, Leslie Baxter, Gene Alexander, Douglas G. Walker, and Eric M. Reiman
Relative risk of spread of symptoms among the focal onset primary dystonias., Elliott M Weiss, Tamara Hershey, Morvarid Karimi, Brad Racette, Samer D Tabbal, Jonathan W Mink, Randal C Paniello, and Joel S Perlmutter
Herbicide Exposure Modifies GSTP1 Haplotype Association to Parkinson Onset Age: the GenePD Study, J. B. Wilk, J. E. Tobin, O. Suchowersky, Holly A. Shill, C. Klein, G. F. Wooten, M. F. Lew, M. H. Mark, M. Guttman, R. L. Watts, C. Singer, J. H. Growdon, J. C. Latourelle, M. H. Saint-Hilaire, A. L. DeStefano, R. Prakash, S. Williamson, C. J. Berg, M. Sun, and et al.
Submissions from 2005
Psychometric properties of the Revised Child Anxiety and Depression Scale in a clinical sample, Bruce F. Chorpita, Catherine E. Moffitt, and Jennifer Gray
Pathological gambling caused by drugs used to treat Parkinson disease, M. Leann Dodd, Kevin J. Klos, James H. Bower, Yonas E. Geda, Keith A. Josephs, and J. Eric Ahlskog
Idiopathic intracranial hypertension, polycystic-ovary syndrome, and thrombophilia, Charles J. Glueck, Dawit Aregawi, Naila Goldenberg, Karl C. Golnik, Luann Sieve, and Ping Wang
Idiopathic intracranial hypertension: associations with thrombophilia and hypofibrinolysis in men, Charles J. Glueck, Naila Goldenberg, Karl Golnik, Luann Sieve, and Ping Wang
Response to diet and metformin in women with idiopathic intracranial hypertension with and without concurrent polycystic ovary syndrome or hyperinsulinemia, Charles J. Glueck, Karl C. Golnik, Dawit Aregawi, Naila Goldenberg, Luann Sieve, and Ping Wang
Amaurosis fugax: associations with heritable thrombophilia, C J. Glueck, Naila Goldenberg, Howard Bell, Karl Golnik, and Ping Wang
New mandate in resident education, Karl C. Golnik
The ophthalmic clinical evaluation exercise: reliability determination, Karl C. Golnik and Linda Goldenhar
Assessment of ophthalmology resident on-call performance, Karl C. Golnik, Andrew G. Lee, and Keith Carter
Diagnostic yield for neuroimaging in patients with unilateral eye or facial pain, Hooman Harooni, Karl C. Golnik, Brooke Geddie, Eric R. Eggenberger, and Andrew G. Lee
The ACNS Subcommittee on Research Terminology for Continuous EEG Monitoring: Proposed standardized terminology for rhythmic and periodic EEG patterns encountered in critically ill patients, Lawrence J. Hirsch, Richard P. Brenner, Frank W. Drislane, Elson So, Peter W. Kaplan, Kenneth G. Jordan, Susan T. Herman, Suzette M. LaRoche, Bryan Young, Thomas P. Bleck, Mark L. Scheuer, and Ronald G. Emerson
Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study, Samer Karamohamed, L I. Golbe, M H. Mark, A M. Lazzarini, O Suchowersky, N Labelle, Mark Guttman, L J. Currie, G F. Wooten, M Stacy, M Saint-Hilaire, R G. Feldman, J Liu, C M. Shoemaker, J B. Wilk, A L. DeStefano, J C. Latourelle, G Xu, R Watts, J Growdon, M Lew, C Waters, P Vieregge, P P. Pramstaller, C Klein, B A. Racette, J S. Perlmutter, A Parsian, Carlos Singer, E Montgomery, K Baker, and J F. Gusella
BDNF Genetic Variants are Associated With Onset Age of Familial Parkinson Disease: GenePD Study, S. Karamohamed, J. C. Latourelle, B. A. Racette, J. S. Perlmutter, G. F. Wooten, M. Lew, C. Klein, Holly A. Shill, L. I. Golbe, M. H. Mark, M. Guttman, G. Nicholson, J. B. Wilk, M. Saint-Hilaire, A. L. DeStefano, R. Prakash, S. Tobin, J. Williamson, O. Suchowersky, and et al.
Vasculitic neuropathy, Shafeeq S. Ladha and P. James B. Dyck
Case of Neuroleptic Malignant-Like Syndrome Precipitated by Abrupt Fava Bean Discontinuance, Shafeeq S. Ladha, Russell Walker, and Holly A. Shill
Using the Journal Club to teach and assess competence in practice-based learning and improvement: a literature review and recommendation for implementation, Andrew G. Lee, H Culver Boldt, Karl C. Golnik, Anthony C. Arnold, Thomas A. Oetting, Hilary A. Beaver, Richard J. Olson, and Keith Carter
The diagnostic yield of the evaluation for isolated unexplained optic atrophy, Andrew G. Lee, Felix Y. Chau, Karl C. Golnik, Randy H. Kardon, and Michael Wall
Radiological appearances in a rare case of tracheomegaly, tracheal diverticulosis, bronchomegaly and bronchiectasis, Balakrishnan Menon, Anupam Malik, Ayushi Chugh, and Bhagirath Vashishat
Isolated bibrachial plexopathy in a patient with type 2 diabetes, Suraj A. Muley, Gareth J. Parry, and Nacide G. Ercan-Fang
Volume changes in the gallbladder in association with various radiologic examinations., Hasan Nazaroglu, Cihan Akgül, Yaşar Bükte, Aslan Bilici, and Masum Simşek
Prevalence of parkinsonism and relationship to exposure in a large sample of Alabama welders, B A. Racette, S D. Tabbal, D Jennings, L Good, J S. Perlmutter, and B Evanoff
[18F]FDOPA PET and clinical features in parkinsonism due to manganism, Brad A. Racette, Jo Ann Antenor, Lori McGee-Minnich, Stephen M. Moerlein, Tom O. Videen, Vikas Kotagal, and Joel S. Perlmutter
The use of memantine in dementia with Lewy bodies, Marwan N. Sabbagh, Ann Marie Hake, Sahir Ahmed, and Martin R. Farlow
Smoking affects the phenotype of Alzheimer disease, Marwan N. Sabbagh, S. L. Tyas, S. C. Emery, L. A. Hansen, M. F. Alford, R. T. Reid, P. Tiraboschi, and L. J. Thal
Is the functional decline of Parkinson's disease similar to the functional decline of Alzheimer's disease?, M. N. Sabbagh, N. Silverberg, S. Bircea, B. Majeed, S. Samant, J. N. Caviness, B. Reisberg, and C. H. Adler
Prevalence of parkin gene mutations and variations in idiopathic Parkinson's disease., Rashmi Sinha, Brad Racette, Joel S Perlmutter, and Abbas Parsian
Autoimmune Hearing Loss in Chronic Inflammatory Demyelinating Polyneuropathy, K. Sivakumar and Terry D. Fife
Cholesterol, copper and Aβ in controls, MCI, AD and the AD cholesterol-lowering treatment trial (ADCLT), D. Larry Sparks, Suzana Petanceska, Marwan Sabbagh, Donald Connor, Holly Soares, Charles Adler, Jean Lopez, Chuck Ziolkowski, Jeff Lochhead, and Patrick Browne
Atorvastatin for the treatment of mild to moderate Alzheimer disease: Preliminary results, D. Larry Sparks, Marwan N. Sabbagh, Donald J. Connor, Jean Lopez, Lenore J. Launer, Patrick Browne, Dawn Wasser, Sherry Johnson-Traver, Jeff Lochhead, and Chuck Ziolwolski
Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD, D. Larry Sparks, Marwan N. Sabbagh, Donald J. Connor, Jean Lopez, Lenore J. Launer, Suzana Petanceska, Patrick Browne, Dawn Wassar, Sherry Johnson-Traver, Jeff Lochhead, and Chuck Ziolkowski
Submissions from 2004
Balint syndrome due to Creutzfeldt-Jakob disease, Beau M. Ances, J. M. Ellenbogen, S. T. Herman, D. Jacobs, D. S. Liebeskind, A. Chatterjee, and S. L. Galetta
Neurosyphilis and status epilepticus: Case report and literature review, Beau M. Ances, Renee Shellhaus, Mark J. Brown, O. Vanessa Rios, Susan T. Herman, and Jacqueline A. French
Low-Grade Glioma: Supratentorial Astrocytoma Oligodendroglioma and Oligoastrocytoma in Adults, Lynn S. Ashby and William R. Shapiro
Missed insulin meal boluses and elevated hemoglobin A1c levels in children receiving insulin pump therapy., Jonathan Burdick, H Peter Chase, Robert H Slover, Kerry Knievel, Laura Scrimgeour, Aristides K Maniatis, and Georgeanna J Klingensmith
Sensitivity to Expectancy Violations in Healthy Aging and Mild Cognitive Impairment, Juliet E. Davie, Tamiko Azuma, Stephen D. Goldinger, Donald J. Connor, Marwan N. Sabbagh, and Nina B. Silverberg
De novo genesis of neuropsychiatric symptoms in Mild Cognitive Impairment (MCI), Yonas E. Geda, Glenn E. Smith, David S. Knopman, Bradley F. Boeve, Eric G. Tongalos, Robert J. Ivnik, David A. Mrazek, Steven D. Edland, and Ronald C. Petersen
Neuro-ophthalmologic manifestations of systemic disease: rheumatologic/Inflammatory, Karl C. Golnik
The Ophthalmic Clinical Evaluation Exercise (OCEX), Karl C. Golnik, Linda M. Goldenhar, John W. Gittinger, and Jay M. Lustbader
The monocular vertical prism dissociation test, Karl C. Golnik, Andrew G. Lee, and Eric R. Eggenberger
Single unprovoked seizures, Susan T. Herman
Hippocampal adaptation to face repetition in healthy elderly and mild cognitive impairment, Sterling C. Johnson, Leslie C. Baxter, Lana Susskind-Wilder, Donald J. Connor, Marwan N. Sabbagh, and Richard J. Caselli
Regional Cerebral Blood Flow Correlates of the Severity of Writer's Cramp Symptoms, Alicja Lerner, Holly A. Shill, Takashi Hanakawa, Khalaf Bushara, Andrew Goldfine, and Mark Hallett
Isolated gait ataxia due to cerebellar vermis infarct, Suraj Ashok Muley and Khalafalla O. Bushara
Association of a variation in the promoter region of the brain-derived neurotrophic factor gene with familial Parkinson's disease., Abbas Parsian, Rashmi Sinha, Brad Racette, Jing H Zhao, and Joel S Perlmutter
Association of variations in monoamine oxidases A and B with Parkinson's disease subgroups., A Parsian, B Racette, Z H Zhang, M Rundle, and J S Perlmutter
Novel haplotypes in 17q21 are associated with progressive supranuclear palsy, Pau Pastor, Mario Ezquerra, J Christian Perez, Sumi Chakraverty, Joanne Norton, Brad A. Racette, Dan McKeel, Joel S. Perlmutter, Eduardo Tolosa, and Alison M. Goate
Teaching Motivational Interviewing to First-Year Medical Students to Improve Counseling Skills in Health Behavior Change, Maria K. Poirier, Matthew M. Clark, Jane H. Cerhan, Sandhya Pruthi, Yonas E. Geda, and Lowell C. Dale
Mapping of Sudden Infant Death With Dysgenesis of the Testes Syndrome (SIDDT) by a SNP Genome Scan and Identification of TSPYL Loss of Function, Erik G. Puffenberger, Diane Hu-Lince, Jennifer M. Parod, David W. Craig, Seth E. Dobrin, Andrew R. Conway, Elizabeth A. Donarum, Kevin A. Strauss, Travis Dunckley, Javier F. Cardenas, Kara R. Melmed, Courtney A. Wright, Winnie Liang, Phillip Stafford, C. Robert Flynn, D. Holmes Morton, and Dietrich A. Stephan
Pathophysiology of parkinsonism due to hydrocephalus, B A. Racette, G J. Esper, J Antenor, K J. Black, A Burkey, S M. Moerlein, T O. Videen, V Kotagal, J G. Ojemann, and J S. Perlmutter
Case series of clinically probable dementia with lewy bodies in two Native Americans, Marwan N. Sabbagh, Nina B. Silverberg, Douglas Walker, Donald J. Connor, James D. Seward, Ida P. Crocker-Sabbagh, Rochelle L. Descheny, Minnie Jim, and Leslie C. Baxter
Is there a characteristic lipid profile in Alzheimer's disease?, Marwan Sabbagh, H. Reza Zahiri, Joanne Ceimo, Kimbal Cooper, William Gaul, Donald Connor, and D. Larry Sparks
Omental infarct: an unusual CT appearance after superior mesenteric artery occlusion, Ajay K. Singh, Lea M. Alhilali, Debra A. Gervais, and Peter R. Mueller
Levodopa with carbidopa diminishes glycogen concentration, glycogen synthase activity, and insulin-stimulated glucose transport in rat skeletal muscle, Jill L. Smith, Jeong-Sun Ju, Bithika M. Saha, Brad A. Racette, and Jonathan S. Fisher
Alzheimer disease without neocortical neurofibrillary tangles: "A second look", P. Tiraboschi, M. N. Sabbagh, L. A. Hansen, D. P. Salmon, A. Merdes, A. Gamst, E. Masliah, M. Alford, L. J. Thal, and Jody Corey-Bloom
Submissions from 2003
Hippocampal sclerosis dementia with tauopathy, Thomas G. Beach, Lucia Sue, Sarah Scott, Kathryn Layne, Amanda Newell, Douglas Walker, Matthew Baker, Naraju Sahara, Shu Hui Yen, Michael Hutton, Richard Caselli, Charles Adler, Donald Connor, and Marwan Sabbagh
Abnormal corticomuscular coherence is associated with the small amplitude cortical myoclonus in Parkinson's disease, John N. Caviness, Charles H. Adler, Marwan N. Sabbagh, Donald J. Connor, Jose L. Hernandez, and Terrence D. Lagerlund
Dystonia in a patient with ring chromosome 21, Craig E. Hou, Bradley L. Schlaggar, and Brad A. Racette
A haplotype at the PARK3 locus influences onset age for Parkinson's disease: the GenePD study, S Karamohamed, A L. DeStefano, J B. Wilk, C M. Shoemaker, L I. Golbe, M H. Mark, A M. Lazzarini, O Suchowersky, N Labelle, M Guttman, L J. Currie, G F. Wooten, M Stacy, M Saint-Hilaire, R G. Feldman, K M. Sullivan, G Xu, R Watts, J Growdon, M Lew, C Waters, P Vieregge, P P. Pramstaller, C Klein, B A. Racette, J S. Perlmutter, A Parsian, C Singer, E Montgomery, K Baker, J F. Gusella, and S J. Fink
The evaluation of preprocessing choices in single-subject BOLD fMRI using NPAIRS performance metrics, Stephen LaConte, Jon Anderson, Suraj Muley, James Ashe, Sally Frutiger, Kelly Rehm, Lars Kai Hansen, Essa Yacoub, Xiaoping Hu, David Rottenberg, and Stephen Strother
Recurrent orthostatic numbness with carotid stenosis and beta-blocker use, Kamakshi Lakshminarayan, Stephen Holloway, and Suraj Muley
Discrete and Dynamic Scaling of the Size of Continuous Graphic Movements of Parkinsonian Patients and Elderly Controls, M. G. Longstaff, Padma R. Mahant, M. A. Stacy, A. W. Van Gemmert, B. C. Leis, and G. E. Stelmach
Autoimmune rippling muscle, Suraj Ashok Muley and John W. Day
Botulinum toxin B reduces sialorrhea in parkinsonism, Brad A. Racette, Laura Good, Sandy Sagitto, and Joel S. Perlmutter
Effects of donepezil treatment on rat nicotinic acetylcholine receptor levels in vivo and in vitro, Richard T. Reida and Marwan N. Sabbagh
Length of stay in skilled nursing facilities is longer for patients with dementia, Marwan N. Sabbagh, Nina Silverberg, Bashar Majeed, Shefali Samant, D. Larry Sparks, James Seward, and Donald J. Connor
A Position Paper: Based on Observational Data Indicating an Increased Rate of Altered Blood Chemistry Requiring Withdrawal from the Alzheimer's Disease Cholesterol-Lowering Treatment Trial (ADCLT), D. Larry Sparks, Jean Lopez, Don Connor, Marwan Sabbagh, Jim Seward, and Patrick Browne
Is cholesterol a culprit in Alzheimer's disease?, D. Larry Sparks, Marwan N. Sabbagh, John C.S. Breitner, and John C. Hunsaker
Comparison of the Short Test of Mental Status and the Mini-Mental State Examination in Mild Cognitive Impairment, David F. Tang-Wai, David S. Knopman, Yonas E. Geda, Steven D. Edland, Glenn E. Smith, Robert J. Ivnik, Eric G. Tangalos, Bradley F. Boeve, and Ronald C. Petersen
A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease, George S. Zubenko, Wendy N. Zubenko, Susan McPherson, Eleanor Spoor, Deborah B. Marin, Martin R. Farlow, Glenn E. Smith, Yonas E. Geda, Jeffrey L. Cummings, Ronald C. Petersen, and Trey Sunderland
Submissions from 2002
Progressive aphasia with Lewy bodies, Richard J. Caselli, Thomas G. Beach, Lucia I. Sue, Donald J. Connor, and Marwan N. Sabbagh
Prognosis of ischemic internuclear ophthalmoplegia, Eric Eggenberger, Karl Golnik, Andrew Lee, Ronel Santos, Analyn Suntay, Banu Satana, Michael Vaphlades, Charles Stevens, David Kaufman, Michael Wall, and Randy Kardon
Infectious optic neuropathy, Karl C. Golnik
Epilepsy after brain insult: Targeting epileptogenesis, Susan T. Herman
The quantitative evaluation of functional neuroimaging experiments: Mutual information learning curves, U. Kjems, L. K. Hansen, J. Anderson, S. Frutiger, S. Muley, J. Sidtis, D. Rottenberg, and S. C. Strother
Phenotypic variability leads to under-recognition of HNPP, Neeraj Kumar, Suraj Muley, Anthony Pakiam, and Gareth J. Parry
Delirium resulting from paraneoplastic limbic encephalitis caused by Hodgkin's disease, Simon Kung, Paul S. Mueller, Yonas E. Geda, and Lois E. Krahn
MRI in isolated sixth nerve palsies, A G. Lee, E Eggenberger, K Golnik, and N R. Miller
Sleep apnea and intracranial hypertension in men, Andrew G. Lee, Karl Golnik, Randy Kardon, Michael Wall, Eric Eggenberger, and Sunita Yedavally
Parkinson's disease and apolipoprotein E: possible association with dementia but not age at onset., Abbas Parsian, Brad Racette, L Jane Goldsmith, and Joel S Perlmutter
Ptosis as a remote effect of therapeutic botulinum toxin B injection, B A. Racette, G Lopate, L Good, S Sagitto, and J S. Perlmutter
A multi-incident, Old-Order Amish family with PD, B A. Racette, M Rundle, J C. Wang, A Goate, N L. Saccone, M Farrer, S Lincoln, J Hussey, S Smemo, J Lin, B Suarez, A Parsian, and J S. Perlmutter
Clinical features and comorbidity of mood fluctuations in Parkinson's disease, Brad A. Racette, Johanna M. Hartlein, Tamara Hershey, Jonathan W. Mink, Joel S. Perlmutter, and Kevin J. Black
Secondary nonresponsiveness to new bulk botulinum toxin A (BCB2024), Brad A. Racette, Mikula Stambuk, and Joel S. Perlmutter
Respiratory Complications of Parkinson's Disease, Holly A. Shill and Mark Stacy
HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advise to use one that crosses the blood-brain barrier, D. L. Sparks, D. J. Connor, P. J. Browne, J. E. Lopez, and M. N. Sabbagh
Should the guidelines for monitoring serum cholesterol levels in the elderly be re-evaluated?, D. L. Sparks, D. J. Connor, P. Browne, and M. N. Sabbagh
Sun, moon, and stars, Kelly M. Vitousek and Jennifer Gray
Submissions from 2001
Intra-Arterial Cisplatin Plus Oral Etoposide for the Treatment of Recurrent Malignant Glioma: A Phase II Study, Lynn S. Ashby and W. R. Shapiro
Polka music and semantic dementia, Bradley F. Boeve and Yonas E. Geda