Osmotic Demyelination Syndrome as a Consequence of Treating Hyperammonemia in a Patient With Ornithine Transcarbamylase Deficiency
Department
neurology
Document Type
Article
Abstract
A 7-year-old female patient with a new diagnosis of ornithine transcarbamylase deficiency was treated for hyperammonemia with a standard protocol. Several days later, she developed ataxia, dysmetria, and dysarthria. Magnetic resonance imaging of the brain demonstrated pontine and extrapontine white matter changes consistent with osmotic demyelination. Classically described as a consequence of hyponatremia treatment, osmotic demyelination syndrome has rarely been associated with other entities. This case suggests a potentially serious complication of the standard therapy for hyperammonemia in patients with ornithine transcarbamylase deficiency.
Medical Subject Headings
neurology
Publication Date
2009
Publication Title
Journal of Child Neurology
ISSN
0883-0738
Volume
24
Issue
7
First Page
884
Last Page
886
Digital Object Identifier (DOI)
10.1177/0883073808331349
Recommended Citation
Cardenas, Javier F. and Bodensteiner, John B., "Osmotic Demyelination Syndrome as a Consequence of Treating Hyperammonemia in a Patient With Ornithine Transcarbamylase Deficiency" (2009). Neurology. 40.
https://scholar.barrowneuro.org/neurology/40