Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment

Authors

Jon Valla, Barrow Neurological Institute
Lonnie Schneider, Barrow Neurological Institute
Tracy Niedzielko, Barrow Neurological Institute
Keith D. Coon, Arizona Alzheimer's Consortium
Richard Caselli, Mayo Clinic Scottsdale-Phoenix, Arizona
Marwan N. Sabbagh, Banner Sun Health Research InstituteFollow
Geoffrey L. Ahern, The University of Arizona Health Sciences
Leslie Baxter, Barrow Neurological InstituteFollow
Gene Alexander, Arizona State University
Douglas G. Walker, Banner Sun Health Research Institute
Eric M. Reiman, Arizona Alzheimer's Consortium

Document Type

Article

Abstract

Mitochondrial abnormalities are found in Alzheimer's disease (AD), but previous reports have not examined at-risk groups. In subjects with AD, mild cognitive impairment (MCI), and non-demented aged controls, platelet and lymphocyte mitochondria were isolated and analyzed for Complexes I, III, and IV of the electron transport chain. Western blots were used to control for differential enrichment of samples. Results demonstrated significant declines in Complexes III and IV in AD, and a significant decline in Complex IV in MCI. This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease. © 2006 Mitochondria Research Society.

Publication Date

12-1-2006

Publication Title

Mitochondrion

ISSN

15677249

Volume

6

Issue

6

First Page

323

Last Page

330

PubMed ID

17123871

Digital Object Identifier (DOI)

10.1016/j.mito.2006.10.004

Recommended Citation

Valla, Jon; Schneider, Lonnie; Niedzielko, Tracy; Coon, Keith D.; Caselli, Richard; Sabbagh, Marwan N.; Ahern, Geoffrey L.; Baxter, Leslie; Alexander, Gene; Walker, Douglas G.; and Reiman, Eric M., "Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment" (2006). Neurology. 906.
https://scholar.barrowneuro.org/neurology/906