BDNF Genetic Variants are Associated With Onset Age of Familial Parkinson Disease: GenePD Study

Authors

S. Karamohamed
J. C. Latourelle
B. A. Racette
J. S. Perlmutter
G. F. Wooten
M. Lew
C. Klein
Holly A. Shill, Barrow Neurological InstituteFollow
L. I. Golbe
M. H. Mark
M. Guttman
G. Nicholson
J. B. Wilk
M. Saint-Hilaire
A. L. DeStefano
R. Prakash
S. Tobin
J. Williamson
O. Suchowersky
et al.

Department

neurology

Document Type

Article

Abstract

Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

Medical Subject Headings

neurology

Publication Date

2005

Publication Title

Neurology

ISSN

0028-3878

Volume

65

Issue

11

First Page

1823

Last Page

1825

Digital Object Identifier (DOI)

10.1212/01.wnl.0000187075.81589.fd

Recommended Citation

Karamohamed, S.; Latourelle, J. C.; Racette, B. A.; Perlmutter, J. S.; Wooten, G. F.; Lew, M.; Klein, C.; Shill, Holly A.; Golbe, L. I.; Mark, M. H.; Guttman, M.; Nicholson, G.; Wilk, J. B.; Saint-Hilaire, M.; DeStefano, A. L.; Prakash, R.; Tobin, S.; Williamson, J.; Suchowersky, O.; and al., et, "BDNF Genetic Variants are Associated With Onset Age of Familial Parkinson Disease: GenePD Study" (2005). Neurology. 242.
https://scholar.barrowneuro.org/neurology/242