The Barrow Neurological Institute is proud of its reputation as a medical research facility and is home to some of the most sophisticated research programs outside of an academic setting in the Southwestern United States. Researchers in the Barrow Neurosurgery Research Center are devoted to learning more about the causes of and treatments for a wide range of disorders, such as stroke, aneurysms, spinal cord injury, and hydrocephalus. Our research has led to treatments that are being used around the world. Within the Department are neurosurgeons who subspecialize in cerebrovascular and skull base, functional and stereotactic, pediatric, spine, tumor, and endovascular neurosurgery.

Physicians, scientists, and expert clinical staff come together with a commitment to developing new techniques for the prevention, diagnosis, treatment, and rehabilitation of neurological illnesses and injuries. The leadership of internationally respected physicians keeps Barrow at the forefront of neuroscience. The compassionate expertise of its extensive staff of nurses, technologists, therapists and support personnel is evident in every aspect of care provided.

Our mission is to advance the knowledge and practice of medicine in neuroscience through basic and clinical research, education of medical professionals, and innovation in clinical techniques and technology.

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Submissions from 2008

IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis, Nadine Bakkar, Jingxin Wang, Katherine J. Ladner, Huating Wang, Jason M. Dahlman, Micheal Carathers, Swarnali Acharyya, Michael A. Rudnicki, Andrew D. Hollenbach, and Denis C. Guttridge

Biomechanical comparison of occipitoatlantal screw fixation techniques: Laboratory investigation, Nicholas C. Bambakidis, Iman Feiz-Erfan, Eric M. Horn, L. Fernando Gonzalez, Seungwon Baek, K. Zafer Yüksel, Anna G.U. Brantley, Volker K.H. Sonntag, and Neil R. Crawford

Hypothalamic Hamartomas Associated With Epilepsy: Ultrastructural Features, John Beggs, Satoko Nakada, Kristina Fenoglio, Jie Wu, Stephen Coons, and John F. Kerrigan

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RAX is required for fly neuronal development and mouse embryogenesis, Richard L. Bennett, William L. Blalock, Eun Jung Choi, Young J. Lee, Yanping Zhang, Lei Zhou, S. Paul Oh, and W. Stratford May

TIS21/BTG2 negatively regulates estradiol-stimulated expansion of hematopoietic stem cells by derepressing Akt phosphorylation and inhibiting mTOR signal transduction, Cho Kim Bong, Sook Ryu Min, S. Paul Oh, and Kyoung Lim In

YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor, Dafna Bonneh-Barkay, Stephanie J. Bissel, Gouji Wang, Kenneth N. Fish, Georgina C.B. Nicholl, Samuel W. Darko, Rafael Medina-Flores, Michael Murphey-Corb, Premeela A. Rajakumar, Julia Nyaundi, John W. Mellors, Robert Bowser, and Clayton A. Wiley

Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects, Laura E. Briggs, Morihiko Takeda, Adolfo E. Cuadra, Hiroko Wakimoto, Melissa H. Marks, Alexandra J. Walker, Tsugio Seki, Suk P. Oh, Jonathan T. Lu, Colin Sumners, Mohan K. Raizada, Nobuo Horikoshi, Ellen O. Weinberg, Kenji Yasui, Yasuhiro Ikeda, Kenneth R. Chien, and Hideko Kasahara

Negative-feedback regulation of proneural proteins controls the timing of neural precursor division, Pao-Ju Chang, Yun-Ling Hsiao, An-Chi Tien, Yi-Chen Li, and Haiwei Pi

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Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's disease, Scott E. Counts, Bin He, Shaoli Che, Stephen D. Ginsberg, and Elliott J. Mufson

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Galanin in Alzheimer's disease: Neuroinhibitory or neuroprotective?, S. E. Counts, S. E. Perez, and E. J. Mufson

Biomechanical consequences of cervical spondylectomy versus corpectomy, Şeref Doǧan, Seungwon Baek, Volker K.H. Sonntag, and Neil R. Crawford

Hypersensitivity Of Aquaporin 4-Deficient Mice To 1-Methyl-4-Phenyl-1236-Tetrahydropyrindine And Astrocytic Modulation, Yi Fan, Hui Kong, Xueru Shi, Xiulan Sun, Jianhua Ding, Jie Wu, and Gang Hu

Interactive effect of sulfur and nitrogen on nitrogen accumulation and harvest in oilseed crops differing in nitrogen assimilation potential, I. S. Fazili, A. Jamal, S. Ahmad, Muzain Masoodi, J. S. Khan, and M. Z. Abdin

The pterional-transsylvian approach: An analytical study, Eberval Gadelha Figueiredo, Pushpa Deshmukh, Joseph M. Zabramski, Mark C. Preul, Neil R. Crawford, and Robert F. Spetzler

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The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease, Oleg S. Gorbatyuk, Shoudong Li, Layla F. Sullivan, Weijun Chen, Galina Kondrikova, Fredric P. Manfredsson, Ronald J. Mandel, and Nicholas Muzyczka

Helmet use and associated spinal fractures in motorcycle crash victims, Pamela W. Goslar, Neil R. Crawford, Scott R. Petersen, Jeffrey R. Wilson, and Timothy Harrington

Tnk1/Kos1 knockout mice develop spontaneous tumors, Sarasija Hoare, Kishalay Hoare, Mary K. Reinhard, Young J. Lee, S. Paul Oh, and W. Stratford May

Genetic ablation of the Bmpr2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension, Kwon Ho Hong, Young Jae Lee, Eunji Lee, Sung Ok Park, Chul Han, Hideyuki Beppu, En Li, Mohan K. Raizada, Kenneth D. Bloch, and S. Paul Oh

Transfacet screw placement for posterior fixation of C-7: Technical note, Eric M. Horn, Nicholas Theodore, Neil R. Crawford, Nicholas C. Bambakidis, and Volker K.H. Sonntag

αConotoxin Arenatus Ib[V11Lv16D] Is A Potent And Selective Antagonist At Rat And Human Native α7 Nicotinic Acetylcholine Receptors, Neal Innocent, Phil D. Livingstone, Arik Hone, Atsuko Kimura, Tracey Young, Paul Whiteaker, J. Michael McIntosh, and Susan Wonnacott

Voltage-gated K+ channel dysfunction in myocytes from a dog model of subarachnoid hemorrhage, Babak S. Jahromi, Yasuo Aihara, Jinglu Ai, Zhen Du Zhang, Elena Nikitina, and Robert Loch MacDonald

Preserved BK channel function in vasospastic myocytes from a dog model of subarachnoid hemorrhage, Babak S. Jahromi, Yasuo Aihara, Jinglu Ai, Zhen Du Zhang, George Weyer, Elena Nikitina, Reza Yassari, Khaled M. Houamed, and R. Loch MacDonald

Temporal profile of potassium channel dysfunction in cerebrovascular smooth muscle after experimental subarachnoid haemorrhage, Babak S. Jahromi, Yasuo Aihara, Jinglu Ai, Zhen Du Zhang, George Weyer, Elena Nikitina, Reza Yassari, Khaled M. Houamed, and R. Loch Macdonald

Biomechanical comparison of a novel C1 posterior locking plate with the harms technique in a C1-C2 fixation model, Brian P. Kelly, John A. Glaser, and Denis J. DiAngelo

Biomechanical testing of a novel four-rod technique for lumbo-pelvic reconstruction, Brian P. Kelly, Francis H. Shen, John S. Schwab, Vincent Arlet, and Denis J. Diangelo

Gabaa Receptor-Mediated Activation Of L-Type Calcium Channels Induces Neuronal Excitation In Surgically Resected Human Hypothalamic Hamartomas, Do Young Kim, Kristina A. Fenoglio, Timothy A. Simeone, Stephen W. Coons, Jie Wu, Yongchang Chang, John F. Kerrigan, and Jong M. Rho

Protective effect of C5a receptor inhibition after murine reperfused stroke, Grace H. Kim, J Mocco, David K. Hahn, Christopher P. Kellner, Ricardo J. Komotar, Andrew F. Ducruet, William J. Mack, and E Sander Connolly

The role of complement in stroke therapy, Ricardo J. Komotar, Grace H. Kim, Marc L. Otten, Benjamin Hassid, J Mocco, Michael E. Sughrue, Robert M. Starke, William J. Mack, Andrew F. Ducruet, Maxwell B. Merkow, Matthew C. Garrett, and E Sander Connolly

Quantitative analysis of exposure of staged orbitozygomatic and retrosigmoid craniotomies for lesions of the clivus with supratentorial extension., Andrew S. Little, Pakrit Jittapiromsak, Neil R. Crawford, Pushpa Deshmukh, Mark C. Preul, Robert F. Spetzler, and Nicholas C. Bambakidis

Agonist-Induced Hump Current Production In Heterologously-Expressed Human α4β2-Nicotinic Acetylcholine Receptors, Qiang Liu, Ke Wei Yu, Yong Chang, Ronald J. Lukas, and Jie Wu

Using a novel resource to decrease proteomic biomarker identification time., Jonathan L. Lustgarten, Shyam Visweswaran, Himanshu Grover, Chad P. Kimmel, Henrik Ryberg, Robert P. Bowser, Vanathi Gopalakrishnan, and William R. Hogan

Deep hypothermic circulatory arrest for complex cerebral aneurysms: lessons learned, William J. Mack, Andrew F. Ducruet, Peter D. Angevine, Ricardo J. Komotar, Debra B. Shrebnick, Niloo M. Edwards, Craig R. Smith, Eric J. Heyer, Linda Monyero, E Sander Connolly, and Robert A. Solomon

Doppler ultrasonography screening of poor-grade subarachnoid hemorrhage patients increases the diagnosis of deep venous thrombosis, William J. Mack, Andrew F. Ducruet, Zachary L. Hickman, James T. Kalyvas, Justin R. Cleveland, J Mocco, Michael Schmidt, Stephan A. Mayer, and E Sander Connolly

Pupillary reactivity upon hospital admission predicts long-term outcome in poor grade aneurysmal subarachnoid hemorrhage patients, William J. Mack, Zachary L. Hickman, Andrew F. Ducruet, James T. Kalyvas, Matthew C. Garrett, Robert M. Starke, Ricardo J. Komotar, Sean D. Lavine, Phil M. Meyers, Stephan A. Mayer, and E Sander Connolly

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Elevation of monocyte chemoattractant protein-1 in patients experiencing neurocognitive decline following carotid endarterectomy, W. J. Mack, A. F. Ducruet, Z. L. Hickman, J. Zurica, R. M. Starke, M. C. Garrett, R. J. Komotar, D. O. Quest, R. A. Solomon, E. J. Heyer, and E. Sander Connolly

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Neural Stem Cells Confer Unique Pinwheel Architecture to the Ventricular Surface in Neurogenic Regions of the Adult Brain, Zaman Mirzadeh, Florian T. Merkle, Mario Soriano-Navarro, Jose Manuel Garcia-Verdugo, and Arturo Alvarez-Buylla

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Cholinergic system during the progression of Alzheimer's disease: Therapeutic implications, Elliott J. Mufson, Scott E. Counts, Sylvia E. Perez, and Stephen D. Ginsberg

Construction Of Sh-Ep1-α4β2-Happ695 Cell Line And Effects Of Nicotinic Agonists On β-Amyloid In The Cells, Huizhen Nie, Zuoqing Li, Ronald J. Lukas, Yinghua Shen, Li Song, Xin Wang, and Ming Yin

ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2, Sung O. Park, Jae Lee Young, Tsugio Seki, Kwon Ho Hong, Naime Fliess, Zhigang Jiang, Alice Park, Xiaofang Wu, Vesa Kaartinen, Beth L. Roman, and S. Paul Oh

Stroke vs. status epilepticus. A case report utilizing CT perfusion, Vladimir Royter, Laurie Paletz, and Michael F. Waters

Protein biomarkers for amyotrophic lateral sclerosis, Henrik Ryberg and Robert Bowser

A mouse model of intracerebral hemorrhage using autologous blood infusion, Michal A. Rynkowski, Grace H. Kim, Ricardo J. Komotar, Marc L. Otten, Andrew F. Ducruet, Brad E. Zacharia, Christopher P. Kellner, David K. Hahn, Maxwell B. Merkow, Matthew C. Garrett, Robert M. Starke, Byung-Moon Cho, Sergei A. Sosunov, and E Sander Connolly

Neuronal and astrocytic apoptosis after subarachnoid hemorrhage: A possible cause for poor prognosis, Mohammed Sabri, Ayako Kawashima, Jinglu Ai, and R. Loch Macdonald

Functional outcome after language mapping for glioma resection, Nader Sanai, Zaman Mirzadeh, and Mitchel S. Berger

The use of surface strain data and a neural networks solution method to determine lumbar facet joint loads during in vitro spine testing, Anna G.U. Sawa and Neil R. Crawford

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In vivo microCT imaging of rodent cerebral vasculature, Youngho Seo, Tomoki Hashimoto, Yoshitsugu Nuki, and Bruce H. Hasegawa

Nitrous oxide induced sub-acute combined degeneration of spinal cord: a case report., K Somyreddy and M Kothari

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Impact of a protocol for acute antifibrinolytic therapy on aneurysm rebleeding after subarachnoid hemorrhage, Robert M. Starke, Grace H. Kim, Andres Fernandez, Ricardo J. Komotar, Zachary L. Hickman, Marc L. Otten, Andrew F. Ducruet, Christopher P. Kellner, David K. Hahn, Markus Chwajol, Stephan A. Mayer, and E. Sander Connolly

TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-forkhead box M1 regulation loop, Jun Park Tae, Yeon Kim Ji, S. Paul Oh, Young Kang So, Wan Kim Bong, Jung Wang Hee, Yong Song Kye, Chin Kim Hyoung, and Kyoung Lim In

Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease, Akanksha Thakur, Sandra L. Siedlak, Sheronica L. James, David J. Bonda, Akanksha Rao, Kate M. Webber, Antoni Camins, Mercé Pallàs, Gemma Casadesus, Hyoung-Gon Lee, Robert Bowser, Arun K. Raina, George Perry, Mark A. Smith, and Xiongwei Zhu

Bioresorbable polylactide interbody implants in an ovine anterior cervical discectomy and fusion model: Three-year results, Kevin A. Thomas, Jeffrey M. Toth, Neil R. Crawford, Howard B. Seim, Lewis L. Shi, Mitchel B. Harris, and A. Simon Turner

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Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster, An Chi Tien, Akhila Rajan, Karen L. Schulze, Don Ryoo Hyung, Melih Acar, Hermann Steller, and Hugo J. Bellen

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Cognitive performance correlates with cortical isopeptide immunoreactivity as well as Alzheimer type pathology, Deng Shun Wang, Hirotake Uchikado, David A. Bennett, Julie A. Schneider, Elliott J. Mufson, Joanne Wu, and Dennis W. Dickson

Sca13., M F Waters and S M Pulst

Synthesis And Characterization Of125I-α-Conotoxin Arib[V11L;V16A] A Selective α7 Nicotinic Acetylcholine Receptor Antagonist, Paul Whiteaker, Michael J. Marks, Sean Christensen, Cheryl Dowell, Allan C. Collins, and J. Michael McIntosh

Gabaa Receptor-Mediated Excitation In Dissociated Neurons From Human Hypothalamic Hamartomas, Jie Wu, Jamie DeChon, Fenqin Xue, Guohui Li, Kevin Ellsworth, Ming Gao, Qiang Liu, Kechun Yang, Chao Zheng, Ping He, Jianglong Tu, Do Young Kim, Jong M. Rho, Harold Rekate, John F. Kerrigan, and Yongchang Chang

Biomechanics of unilateral compared with bilateral lumbar pedicle screw fixation for stabilization of unilateral vertebral disease: Laboratory investigation, Kemal Yücesoy, K. Zafer Yüksel, Seungwon Baek, Volker K.H. Sonntag, and Neil R. Crawford

Occipitocervical vertical distraction injuries: Anatomical biomechanical, and 3-tesla magnetic resonance imaging investigation, K. Zafer Yüksel, Murvet Yüksel, L. Fernando Gonzalez, Seungwon Baek, Joseph E. Heiserman, Volker K.H. Sonntag, and Neil R. Crawford

Structural Determinants For Antagonist Pharmacology That Distinguish The ρ1 Gabac Receptor From Gabaa Receptors, Jianliang Zhang, Fenqin Xue, and Yongchang Chang

A New EAE Model of Brain Demyelination Induced by Intracerebroventricular Pertussis Toxin, C. B. Zhao, S. W. Coons, M. Cui, Fu-Dong Shi, T. L. Vollmer, C. Y. Ma, S. M. Kuniyoshi, and Jiong Shi

GluR1 controls dendrite growth through its binding partner, SAP97, Weiguo Zhou, Lei Zhang, Xiong Guoxiang, Jelena Mojsilovic-Petrovic, Kogo Takamaya, Rita Sattler, Richard Huganir, and Robert Kalb

Submissions from 2007

Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy, Swarnali Acharyya, S Armando Villalta, Nadine Bakkar, Tepmanas Bupha-Intr, Paul M. Janssen, Micheal Carathers, Zhi-Wei Li, Amer A. Beg, Sankar Ghosh, Zarife Sahenk, Michael Weinstein, Katherine L. Gardner, Jill A. Rafael-Fortney, Michael Karin, James G. Tidball, Albert S. Baldwin, and Denis C. Guttridge

Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone, Kazuhide Adachi, Zaman Mirzadeh, Masanori Sakaguchi, Toru Yamashita, Tania Nikolcheva, Yukiko Gotoh, Gary Peltz, Leyi Gong, Takeshi Kawase, Arturo Alvarez-Buylla, Hideyuki Okano, and Kazunobu Sawamoto

Interactive effect of sulfur and nitrogen on nitrate reductase and ATP-sulfurylase activities in relation to seed yield from Psoralea corylifolia L., Saif Ahmad, Inayat Saleem Fazli, Arshad Jamal, Mohd Iqbal, and Malik Zainul Abdin

Structural and functional alterations of cerebellum following fluid percussion injury in rats, Jinglu Ai, Elaine Liu, Eugene Park, and Andrew J. Baker

Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury, Jinglu Ai, Elaine Liu, Jianli Wang, Yonghong Chen, Julie Yu, and Andrew J. Baker

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Activation of caspase-6 in aging and mild cognitive impairment, Steffen Albrecht, Martine Bourdeau, David Bennett, Elliott J. Mufson, Meena Bhattacharjee, and Andréa C. LeBlanc

Mild in vitro trauma induces rapid Glur2 endocytosis, robustly augments calcium permeability and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells, Joshua D. Bell, Jinglu Ai, Yonghong Chen, and Andrew J. Baker

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Simulation of high-frequency sinusoidal electrical block of mammalian myelinated axons, Niloy Bhadra, Emily A. Lahowetz, Stephen T. Foldes, and Kevin L. Kilgore

Evolutionarily conserved mammalian adenine nucleotide translocase 4 is essential for spermatogenesis, Jeffrey V. Brower, Nemanja Rodic, Tsugio Seki, Marda Jorgensen, Naime Fliess, Anthony T. Yachnis, John R. McCarrey, S. Paul Oh, and Naohiro Terada

Focal adhesions regulate Aβ signaling and cell death in Alzheimer's disease, John Caltagarone, Zheng Jing, and Robert Bowser

Controlling synchronization in a neuron-level population model, Niranjan Chakravarthy, Shivkumar Sabesan, Leon Iasemidis, and Kostas Tsakalis

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α7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease, Scott E. Counts, Bin He, Shaoli Che, Milos D. Ikonomovic, Steven T. DeKosky, Stephen D. Ginsberg, and Elliott J. Mufson

Letter to the Editor, Neil R. Crawford

Stiffness of occipital-cervical constructs: Beam theory - Commentary, Neil R. Crawford and Volker K.H. Sonntag

Pre-clinical evaluation of an sLe x-glycosylated complement inhibitory protein in a non-human primate model of reperfused stroke, Andrew F. Ducruet, J Mocco, William J. Mack, Alexander L. Coon, Henry C. Marsh, David J. Pinsky, Zachary L. Hickman, Grace H. Kim, and E Sander Connolly

Hangman's fracture: A biomechanical comparison of stabilization techniques, Neil Duggal, Robert H. Chamberlain, Luis E. Perez-Garza, Adolfo Espinoza-Larios, Volker K.H. Sonntag, and Neil R. Crawford

Traumatic loading of the bryan cervical disc prosthesis: An in vitro study, Neil Duggal, Doron Rabin, Robert H. Chamberlain, Seungwon Baek, and Neil R. Crawford

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Whole-genome analysis of sporadic amyotrophic lateral sclerosis, Travis Dunckley, Matthew J. Huentelman, David W. Craig, John V. Pearson, Szabolcs Szelinger, Keta Joshipura, Rebecca F. Halperin, Chelsea Stamper, Kendall R. Jensen, David Letizia, Sharon E. Hesterlee, Alan Pestronk, Todd Levine, Tulio Bertorini, Michael C. Graves, Tahseen Mozaffar, Carlayne E. Jackson, Peter Bosch, April McVey, Arthur Dick, Richard Barohn, Catherine Lomen-Hoerth, Jeffrey Rosenfeld, Daniel T. O'Connor, Kuixing Zhang, Richard Crook, Henrik Ryberg, Michael Hutton, Jonathan Katz, Ericka P. Simpson, Hiroshi Mitsumoto, and Robert Bowser

Biomechanical comparison of two-level cervical locking posterior screw/rod and hook/rod techniques, Adolfo Espinoza-Larios, Christopher P. Ames, Robert H. Chamberlain, Volker K.H. Sonntag, Curtis A. Dickman, and Neil R. Crawford

Wnt-7A Induces Presynaptic Colocalization Of α7-Nicotinic Acetylcholine Receptors And Adenomatous Polyposis Coli In Hippocampal Neurons, Ginny G. Farías, Ana S. Vallés, Marcela Colombres, Juan A. Godoy, Enrique M. Toledo, Ronald J. Lukas, Francisco J. Barrantes, and Nibaldo C. Inestrosa

Hypothalamic Hamartoma: Basic Mechanisms Of Intrinsic Epileptogenesis, Kristina A. Fenoglio, Jie Wu, Do Young Kim, Timothy A. Simeone, Stephen W. Coons, Harold Rekate, Jong M. Rho, and John F. Kerrigan

The minipterional craniotomy: Technical description and anatomic assessment, Eberval G. Figueiredo, Pushpa Deshmukh, Peter Nakaji, Marcelo U. Crusius, Neil Crawford, Robert F. Spetzler, and Mark C. Preul

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Cortical biochemistry in MCI and Alzheimer disease: Lack of correlation with clinical diagnosis, M. S. Forman, E. J. Mufson, S. Leurgans, D. Pratico, S. Joyce, S. Leight, V. M.Y. Lee, and J. Q. Trojanowski

Biomechanical comparison of instrumented and uninstrumented multilevel cervical discectomy versus corpectomy, Robert M. Galler, Şeref Doǧan, Mary S. Fifield, Hakan Bozkus, Robert H. Chamberlain, Volker K.H. Sonntag, and Neil R. Crawford

In vitro testing of cyto- and genotoxicity of new porphyrin water-soluble metal derivatives, Gennadi Gasparyan, Galina Hovhannisyan, Robert Ghazaryan, Lida Sahakyan, Artak Tovmasyan, Rusanna Grigoryan, Natalia Sarkissyan, Samvel Haroutiunian, and Rouben Aroutiounian

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Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease, Anamitra Ghosh, Avik Roy, Xiaojuan Liu, Jeffrey H. Kordower, Elliott J. Mufson, Dean M. Hartley, Sankar Ghosh, R. Lee Mosley, Howard E. Gendelman, and Kalipada Pahan

Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis, Arie Gruzman, William L. Wood, Evgenia Alpert, M. Dharma Prasad, Robert G. Miller, Jeffery D. Rothstein, Robert Bowser, Ronald Hamilton, Troy D. Wood, Don W. Cleveland, Vishwanath R. Lingappa, and Jian Liu

Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma, Gregory M.T. Hare, C. David Mazer, James S. Hutchison, Anya T. McLaren, Elaine Liu, Alipasha Rassouli, Jinglu Ai, Rachel E. Shaye, Julia A. Lockwood, Cynthia E. Hawkins, Nancy Sikich, Kevin To, and Andrew J. Baker

Activin receptor-like kinase 1 is essential for placental vascular development in mice, Kwon Ho Hong, Tsugio Seki, and S. Paul Oh

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Superior frontal cortex cholinergic axon density in mild cognitive impairment and early Alzheimer disease, Milos D. Ikonomovic, Eric E. Abrahamson, Barbara A. Isanski, Joanne Wuu, Elliott J. Mufson, and Steven T. DeKosky

Role of pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice, Jeong Hoon Joo, Jae Lee Young, Gustavo C. Munguba, Sean Park, Timothy J. Taxter, Mohamed Y. Elsagga, Moira R. Jackson, S. Paul Oh, and Stephen P. Sugrue

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Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma, Keith L. Ligon, Emmanuelle Huillard, Shwetal Mehta, Santosh Kesari, Hongye Liu, John A. Alberta, Robert M. Bachoo, Michael Kane, David N. Louis, Ronald A. DePinho, David J. Anderson, Charles D. Stiles, and David H. Rowitch

Early plasma complement C3a levels correlate with functional outcome after aneurysmal subarachnoid hemorrhage, William J. Mack, Andrew F. Ducruet, Zachary L. Hickman, Matthew C. Garrett, Eli J. Albert, Christopher P. Kellner, J Mocco, and E Sander Connolly

rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease, Fredric P. Manfredsson, Corinna Burger, Layla F. Sullivan, Nicholas Muzyczka, Alfred S. Lewin, and Ronald J. Mandel

Guidelines On Nicotine Dose Selection For In Vivo Research, Shannon G. Matta, David J. Balfour, Neal L. Benowitz, R. Thomas Boyd, Jerry J. Buccafusco, Anthony R. Caggiula, Caroline R. Craig, Allan C. Collins, M. Imad Damaj, Eric C. Donny, Phillip S. Gardiner, Sharon R. Grady, Ulrike Heberlein, Sherry S. Leonard, Edward D. Levin, Ronald J. Lukas, Athina Markou, Michael J. Marks, Sarah E. McCallum, Neeraja Parameswaran, Kenneth A. Perkins, Marina R. Picciotto, Maryka Quik, Jed E. Rose, Adrian Rothenfluh, William R. Schafer, Ian P. Stolerman, Rachel F. Tyndale, Jeanne M. Wehner, and Jeffrey M. Zirger

Mosaic organization of neural stem cells in the adult brain, Florian T. Merkle, Zaman Mirzadeh, and Arturo Alvarez-Buylla

Iptakalim A Vascular Atp-Sensitive Potassium (Katp) Channel Opener Closes Rat Pancreatic β-Cell Katp Channels And Increases Insulin Release, Naoko Misaki, Xia Mao, Yu Fung Lin, Sechiko Suga, Guo Hui Li, Qiang Liu, Yongchang Chang, Hai Wang, Makoto Wakui, and Jie Wu

O-desulfated heparin improves outcome after rat cerebral ischemia/reperfusion injury, J Mocco, Corbett E. Shelton, Paulina Sergot, Andrew F. Ducruet, Ricardo J. Komotar, Marc L. Otten, Sergei A. Sosunov, Robert B. Macarthur, Thomas P. Kennedy, and E Sander Connolly

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Cholinotrophic molecular substrates of mild cognitive impairment in the elderly, Elliott J. Mufson, Scott E. Counts, Margaret Fahnestock, and Stephen D. Ginsberg