A pilot trial of memantine and riluzole in ALS: Correlation to CSF biomarkers

Document Type

Article

Abstract

The objective of this trial was to determine the safety and tolerability of memantine in patients with sporadic ALS and to examine changes in CSF biomarkers during drug therapy. Twenty patients on stable doses of riluzole were enrolled. Patients received memantine, 10 mg b.i.d., for 18 months. Lumbar punctures were performed at baseline, six and twelve months. The ALSFRS was measured at six weeks, 3, 6, 9, 12 and 18 months. Results showed that patients treated with memantine and riluzole had an average rate of decline on the ALSFRS of -0.73 points per month. Patients who progressed faster than -0.5 ALSFRS points per month had an average baseline CSF tau concentration of 574 pg/ml, while those who progressed slower than -0.5 ALSFRS points per month had CSF tau levels that averaged 298 pg/ml (p = 0.006). After therapy with memantine, patients had a 27% decline in CSF tau levels (p= 0.04) and four patients whose CSF tau dropped to healthy control levels lost only -0.42 ALSFRS points per month. In conclusion, memantine was well tolerated in patients with ALS. Patients receiving memantine and riluzole lost on average -0.73 ALSFRS points per month. Furthermore, levels of CSF tau at baseline could be correlated with how rapidly a patient's disease progressed. © 2010 Informa Healthcare.

Keywords

Biomarkers, Memantine, Therapy

Publication Date

12-1-2010

Publication Title

Amyotrophic Lateral Sclerosis

ISSN

17482968

E-ISSN

1471180X

Volume

11

Issue

6

First Page

514

Last Page

519

PubMed ID

20839903

Digital Object Identifier (DOI)

10.3109/17482968.2010.513052

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