Artery of Uchimura: origin and evolution of identification of the vascular supply to the hippocampus

Authors

• Ali Tayebi Meybodi, Department of Neurosurgery, Rutgers New Jersey Medical School, Newark, New Jersey; and.
• Giancarlo Mignucci-Jiménez, Department of Neurosurgery, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.
• Yuan Xu, Department of Neurosurgery, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.
• Mark C. Preul, Department of Neurosurgery, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.

Document Type

Article

Abstract

In 1928, neuroscientist Yushi Uchimura (1897-1980) published a landmark study detailing the hippocampal vasculature. Working in Walther Spielmeyer's Munich laboratory (1925-1927), Uchimura sought evidence for a vascular theory of Ammon's horn sclerosis (AHS). He described an artery supplying the vulnerable sector of the hippocampus, where pathognomonic changes of AHS were noted, and characterized the artery as particularly susceptible to circulatory disturbances. Discovery of this artery led to new concepts and new terminology pertaining to the hippocampus. In addition to having a distinguished career in psychiatry and academia (including a position as University of Tokyo dean), Uchimura was, before attending medical school, one of Japan's best baseball pitchers; he was eventually named Nippon Professional Baseball Organization commissioner and inducted into the Japan Baseball Hall of Fame. Uchimura's description of hippocampal vasculature, which is still subject to debate after nearly a century, brought international attention to AHS and epilepsy and showed the hippocampal vasculature to be variable and vulnerable; important considerations for later neurosurgeons in the development of selective mesial temporal surgery. Prominent figures in neurosurgery have since developed classification systems for the hippocampal vasculature in which the artery of Uchimura remains central. Perhaps no other brain artery has been the nexus for such intense investigation and debate about its association to structure, function, disease, and treatment methodology.

Medical Subject Headings

Male; Humans; Hippocampus; Epilepsy; Arteries; Japan; Epilepsy, Temporal Lobe; Sclerosis (pathology)

Publication Date

10-1-2023

Publication Title

Journal of neurosurgery

E-ISSN

1933-0693

Volume

139

Issue

4

First Page

1128

Last Page

1139

PubMed ID

37086167

Digital Object Identifier (DOI)

10.3171/2023.2.JNS221963

Recommended Citation

Tayebi Meybodi, Ali; Mignucci-Jiménez, Giancarlo; Xu, Yuan; and Preul, Mark C., "Artery of Uchimura: origin and evolution of identification of the vascular supply to the hippocampus" (2023). Neurosurgery. 2324.
https://scholar.barrowneuro.org/neurosurgery/2324