Global brain inflammation in stroke

Authors

Kaibin Shi, Tianjin Medical University
De Cai Tian, Beijing Tiantan Hospital, Capital Medical University
Zhi Guo Li, Tianjin Medical University
Andrew F. Ducruet, Barrow Neurological InstituteFollow
Michael T. Lawton, Barrow Neurological InstituteFollow
Fu Dong Shi, Beijing Tiantan Hospital, Capital Medical University

Document Type

Article

Abstract

Stroke, including acute ischaemic stroke and intracerebral haemorrhage, results in neuronal cell death and the release of factors such as damage-associated molecular patterns (DAMPs) that elicit localised inflammation in the injured brain region. Such focal brain inflammation aggravates secondary brain injury by exacerbating blood–brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell death. In addition to inflammation localised to the injured brain region, a growing body of evidence suggests that inflammatory responses after a stroke occur and persist throughout the entire brain. Global brain inflammation might continuously shape the evolving pathology after a stroke and affect the patients' long-term neurological outcome. Future efforts towards understanding the mechanisms governing the emergence of so-called global brain inflammation would facilitate modulation of this inflammation as a potential therapeutic strategy for stroke.

Publication Date

11-1-2019

Publication Title

The Lancet Neurology

ISSN

14744422

E-ISSN

14744465

Volume

18

Issue

11

First Page

1058

Last Page

1066

PubMed ID

31296369

Digital Object Identifier (DOI)

10.1016/S1474-4422(19)30078-X

Recommended Citation

Shi, Kaibin; Tian, De Cai; Li, Zhi Guo; Ducruet, Andrew F.; Lawton, Michael T.; and Shi, Fu Dong, "Global brain inflammation in stroke" (2019). Neurosurgery. 1352.
https://scholar.barrowneuro.org/neurosurgery/1352