Chronic inflammation, cognitive impairment, and distal brain region alteration following intracerebral hemorrhage

Authors

Elaine Shi, Departments of Neurology and Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
Kaibin Shi, Departments of Neurology and Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
Shenfeng Qiu, Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona, USA.
Kevin N. Sheth, Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Michael T. Lawton, Departments of Neurology and Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.Follow
Andrew F. Ducruet, Departments of Neurology and Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.Follow

Document Type

Article

Abstract

Delayed cognitive decline commonly occurs following intracerebral hemorrhage (ICH), but the mechanisms underlying this phenomenon remain obscure. We therefore investigated the potential mechanisms responsible for impaired cognitive function in a mouse collagenase model of ICH. Following recovery of motor and sensory deficits in the chronic phase of ICH, we noted significant cognitive impairment, which was assessed by the Morris water maze. This finding was accompanied by reduced dendrite spine density of ipsilateral hippocampal CA1 neurons. Reduced synaptic plasticity, manifested by impaired long-term potentiation in hippocampal neurons, was also evident in both ipsilateral and contralateral hemispheres, suggesting that ICH also induces functional alterations in distal brain regions remote from the site of injury. In addition, the accumulation of microglia, infiltration of peripheral immune cells, and generation of reactive oxygen species were observed in both contralateral and ipsilateral hemispheres up to 5 wk post-ICH. Furthermore, depletion of microglia using PLX3397, which inhibits colony stimulating factor 1 receptor, ameliorated this delayed cognitive impairment. Collectively, these results suggest that persistent and diffuse brain inflammation may contribute to cognitive impairment in the chronic stage of ICH recovery.-Shi, E., Shi, K., Qiu, S., Sheth, K. N., Lawton, M. T., Ducruet, A. F. Chronic inflammation, cognitive impairment, and distal brain region alteration following intracerebral hemorrhage.

Medical Subject Headings

Aminopyridines (pharmacology); Animals; Brain (metabolism); Cerebral Hemorrhage (immunology, metabolism); Cognition (drug effects); Cognitive Dysfunction (immunology, metabolism); Disease Models, Animal; Fingolimod Hydrochloride (pharmacology); Flow Cytometry; Hippocampus (metabolism); Inflammation (immunology, metabolism); Male; Mice; Mice, Inbred C57BL; Microglia (metabolism); Neuroimaging; Neuronal Plasticity (drug effects); Pyrroles (pharmacology); Receptors, Granulocyte-Macrophage Colony-Stimulating Factor (antagonists & inhibitors, metabolism)

Publication Date

5-31-2019

Publication Title

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

E-ISSN

1530-6860

Volume

33

Issue

8

First Page

9616

Last Page

9626

PubMed ID

31145859

Digital Object Identifier (DOI)

10.1096/fj.201900257R

Recommended Citation

Shi, Elaine; Shi, Kaibin; Qiu, Shenfeng; Sheth, Kevin N.; Lawton, Michael T.; and Ducruet, Andrew F., "Chronic inflammation, cognitive impairment, and distal brain region alteration following intracerebral hemorrhage" (2019). Neurosurgery. 1347.
https://scholar.barrowneuro.org/neurosurgery/1347