Oxidized low-density lipoprotein predicts recurrent stroke in patients with minor stroke or TIA.

Document Type

Article

Abstract

OBJECTIVE: To investigate the association between oxidized low-density lipoprotein (oxLDL) and recurrent stroke in patients with minor stroke or TIA.

METHODS: In the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial, baseline oxLDL levels were blindly measured in plasma with the 4E6 antibody in the core laboratory. The primary outcome was any stroke within 90 days. The secondary outcomes included any stroke within 1 year and ischemic stroke and combined vascular events within 90 days and 1 year. The associations of oxLDL with recurrent stroke were analyzed by Cox proportional hazards.

RESULTS: Among 3,019 patients included in this study, the median (interquartile range) of oxLDL was 13.96 (6.65-28.81) μg/dL. After adjustment for conventional confounding factors, patients in the highest oxLDL quartile (≥28.81 μg/dL) had a higher risk of recurrent stroke within 90 days (hazard ratio 1.43, 95% confidence interval 1.03-1.98) compared to those in the lowest oxLDL quartile (

CONCLUSIONS: Elevated oxLDL levels can independently predict recurrent stroke in patients with minor stroke or TIA.

CLINICALTRIALSGOV IDENTIFIER: NCT00979589.

Medical Subject Headings

Aged; Aspirin; Blood Pressure; Body Mass Index; Clopidogrel; Double-Blind Method; Female; Follow-Up Studies; Humans; Ischemic Attack, Transient; Lipoproteins, LDL; Male; Middle Aged; Platelet Aggregation Inhibitors; Predictive Value of Tests; Recurrence; Severity of Illness Index; Stroke

Publication Date

9-4-2018

Publication Title

Neurology

ISSN

1526-632X

Volume

91

Issue

10

First Page

947

Last Page

947

PubMed ID

30089614

Digital Object Identifier (DOI)

10.1212/WNL.0000000000006118

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