Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS) study
Document Type
Article
Abstract
BACKGROUND: Intracranial atherosclerotic stenosis (ICAS) is an important cause of ischemic stroke worldwide. The role of high-density lipoprotein cholesterol (HDL-C) or low-density lipoprotein cholesterol (LDL-C) in the development of ICAS remains to be elucidated. In the current study, we investigated the relationship of HDL-C level and the risk of developing ICAS in Chinese patients with acute ischemic stroke. METHODS: From October 2007 to June 2009, a total of 1,984 consecutive ischemic stroke patients were evaluated for the presence of symptomatic ICAS by magnetic resonance angiography (MRA). Patients were classified into two groups: intracranial steno-occlusion (ICAS group, n = 888) and non-intracranial stenosis (NICAS group, n = 1096). Serum lipid profiles were analyzed and compared between the ICAS and NICAS group. RESULTS: Significantly more patients in ICAS group had low HDL-C level (51.6%) than in the NICAS group (42.9%, P<0.001). The observed association remained significant after adjustment for conventional risk factors [(adjusted OR 1.36; 95%CI (1.13-1.63)]. Such predictive value of low level HDL-C persisted even when LDL-C was at very low level(<1.8 mmol/L). Patients in the lowest serum HDL-C quartile (<0.96 mmol/L) had the highest risk of developing ICAS [adjusted OR 1.52; 95%CI (1.17-1.98)] compared to patients in the highest serum HDL-C quartile (≥ 1.32 mmol/L) after adjustments for the covariates. CONCLUSIONS: Low HDL-C level is strongly associated with the development of ICAS. There was an inverse relationship between the level of HDL-C and the risk of developing ICAS.
Medical Subject Headings
China (epidemiology); Cholesterol, HDL (blood); Cohort Studies; Humans; Intracranial Arteriosclerosis (blood, epidemiology, pathology); Magnetic Resonance Angiography; Prospective Studies; Risk Factors; Statistics, Nonparametric; Stroke (blood, epidemiology, pathology)
Publication Date
1-1-2013
Publication Title
PloS one
E-ISSN
1932-6203
Volume
8
Issue
5
First Page
e64395
PubMed ID
23691210
Digital Object Identifier (DOI)
10.1371/journal.pone.0064395
Recommended Citation
Qian, Yining; Pu, Yuehua; Liu, Liping; Wang, David Z.; Zhao, Xingquan; Wang, Chunxue; Wang, Yilong; Liu, Gaifen; Pan, Yuesong; and Wang, Yongjun, "Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS) study" (2013). Neurology. 1800.
https://scholar.barrowneuro.org/neurology/1800