Therapeutic targeting of Toll-like receptors in cutaneous disorders

Authors

Nassim Matin, a 1 Tehran University of Medical Sciences, Research Center for Immunodeficiencies, Children's Medical Center , Dr. Qarib Street Keshavarz Blvd, Tehran 14194, Iran +98 21 6692 9234 ; +98 21 6692 9235 ; rezaei_nima@tums.ac.ir.
Omidreza Tabatabaie, a 1 Tehran University of Medical Sciences, Research Center for Immunodeficiencies, Children's Medical Center , Dr. Qarib Street Keshavarz Blvd, Tehran 14194, Iran +98 21 6692 9234 ; +98 21 6692 9235 ; rezaei_nima@tums.ac.ir.
Payam Mohammadinejad, a 1 Tehran University of Medical Sciences, Research Center for Immunodeficiencies, Children's Medical Center , Dr. Qarib Street Keshavarz Blvd, Tehran 14194, Iran +98 21 6692 9234 ; +98 21 6692 9235 ; rezaei_nima@tums.ac.ir.
Nima Rezaei, a 1 Tehran University of Medical Sciences, Research Center for Immunodeficiencies, Children's Medical Center , Dr. Qarib Street Keshavarz Blvd, Tehran 14194, Iran +98 21 6692 9234 ; +98 21 6692 9235 ; rezaei_nima@tums.ac.ir.

Document Type

Article

Abstract

INTRODUCTION: The role of skin, as a part of the immune system has long been elucidated. Toll-like receptors (TLRs), a group of pattern recognition receptors, are involved in the recognition of invading pathogens, initiation of immune responses and regulation of both innate and adaptive immune systems. There is a growing body of evidence supporting the role of TLRs in the pathophysiology of several skin conditions, which mandates the development and study of therapeutic strategies that target TLRs. AREAS COVERED: With regards to the role of TLRs in pathogenesis of diverse cutaneous conditions, recent advances, as well as the future prospects of therapeutic implications of TLRs in cutaneous disorders is reviewed in this article. EXPERT OPINION: Although non-specific therapeutic strategies seem to reduce the symptoms in majority of patients, a considerable proportion remain untreated or have to deal with inevitable adverse effects of such therapies. Since TLRs regulate many patholophysiological processes, they could be good candidates for more specific therapeutic approaches. TLR targeting as the first recipient of invading pathogens is a growing concept in this field.

Medical Subject Headings

Animals; Dermatologic Agents (adverse effects, pharmacology, therapeutic use); Drug Design; Humans; Molecular Targeted Therapy; Skin Diseases (drug therapy, immunology, physiopathology); Toll-Like Receptors (immunology)

Publication Date

1-1-2015

Publication Title

Expert opinion on therapeutic targets

E-ISSN

1744-7631

Volume

19

Issue

12

First Page

1651

Last Page

63

PubMed ID

26189326

Digital Object Identifier (DOI)

10.1517/14728222.2015.1069275

Recommended Citation

Matin, Nassim; Tabatabaie, Omidreza; Mohammadinejad, Payam; and Rezaei, Nima, "Therapeutic targeting of Toll-like receptors in cutaneous disorders" (2015). Neurology. 1519.
https://scholar.barrowneuro.org/neurology/1519