Development and validation of osteoporosis prescreening model for Iranian postmenopausal women

Authors

Nassim Matin, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Follow
Omidreza Tabatabaie, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Abbasali Keshtkar, Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Kamran Yazdani, Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Mojgan Asadi, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Document Type

Article

Abstract

BACKGROUND: Studies have indicated that the commonly used osteoporosis prescreening tools are not appropriate for use in every nation. This study was designed to develop and validate a prescreening model for bone mineral densitometry among Iranian postmenopausal women. METHODS: From 13613 individuals who were referred for bone mineral densitometry in Shariati hospital in Tehran, 8644 postmenopausal women were considered for the study after excluding men and premenopausal women. Questionnaires regarding the risk factors for osteoporosis were filled for each individual. Bone mineral density at the lumbar vertebrae (L2-L4), femoral neck and total femur was measured by dual X-ray absorptiometry. Using holdout validation, the study sample was divided into two parts; training set (5705) and test set (2939). Logistic regression analysis was performed on the training set. A scoring model was developed and tested in the test set. RESULTS: Based on the training set, a seven-variable model named OPMIP (Osteoporosis Prescreening Model for Iranian Postmenopausal women) was developed with C statistics (area under curve) of 0.72. Using a cut-off of -2.5 for the model, the sensitivity, specificity, positive predictive value and negative predictive value were 72%, 59.5%, 64% and 69% respectively. The model performance was tested in the test set. OPMIP correctly classified 67.10% of cases with a sensitivity and specificity of 73.2% and 61%. CONCLUSIONS: In order to appropriately refer patients for a bone mineral densitometry, OPMIP can be used as a prescreening tool in Iranian Postmenopausal women.

Publication Date

1-1-2015

Publication Title

Journal of diabetes and metabolic disorders

ISSN

2251-6581

Volume

14

First Page

12

PubMed ID

25821747

Digital Object Identifier (DOI)

10.1186/s40200-015-0140-7

Recommended Citation

Matin, Nassim; Tabatabaie, Omidreza; Keshtkar, Abbasali; Yazdani, Kamran; and Asadi, Mojgan, "Development and validation of osteoporosis prescreening model for Iranian postmenopausal women" (2015). Neurology. 1506.
https://scholar.barrowneuro.org/neurology/1506