The pharmacogenomics of severe traumatic brain injury

Authors

Solomon M. Adams, Department of Pharmaceutical Sciences, Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Yvette P. Conley, Health Promotion & Development, School of Nursing, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Amy K. Wagner, Department of Physical Medicine & Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Ruchira M. Jha, Clinical & Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.Follow
Robert Sb Clark, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Samuel M. Poloyac, Department of Pharmaceutical Sciences, Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Patrick M. Kochanek, Clinical & Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Philip E. Empey, Clinical & Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Document Type

Article

Abstract

Pharmacotherapy for traumatic brain injury (TBI) is focused on resuscitation, prevention of secondary injury, rehabilitation and recovery. Pharmacogenomics may play a role in TBI for predicting therapies for sedation, analgesia, seizure prevention, intracranial pressure-directed therapy and neurobehavioral/psychiatric symptoms. Research into genetic predictors of outcomes and susceptibility to complications may also help clinicians to tailor therapeutics for high-risk individuals. Additionally, the expanding use of genomics in the drug development pipeline has provided insight to novel investigational and repurposed medications that may be useful in the treatment of TBI and its complications. Genomics in the context of treatment and prognostication for patients with TBI is a promising area for clinical progress of pharmacogenomics.

Medical Subject Headings

Animals; Brain Injuries, Traumatic (drug therapy, genetics); Humans; Pharmacogenetics (methods); Risk

Publication Date

10-1-2017

Publication Title

Pharmacogenomics

E-ISSN

1744-8042

Volume

18

Issue

15

First Page

1413

Last Page

1425

PubMed ID

28975867

Digital Object Identifier (DOI)

10.2217/pgs-2017-0073

Recommended Citation

Adams, Solomon M.; Conley, Yvette P.; Wagner, Amy K.; Jha, Ruchira M.; Clark, Robert Sb; Poloyac, Samuel M.; Kochanek, Patrick M.; and Empey, Philip E., "The pharmacogenomics of severe traumatic brain injury" (2017). Neurology. 1368.
https://scholar.barrowneuro.org/neurology/1368