Title

Rapidly progressive dementia-associated N-type voltage-gated calcium channel antibody encephalopathy

Document Type

Article

Abstract

Autoimmune encephalopathy is one of the treatable causes of rapidly progressive dementia; however, it is often underdiagnosed. Autoantibodies against voltage-gated calcium channel (VGCC) have been linked to several neurological disorders, including Lambert-Eaton syndrome, but VGCC antibody-associated encephalopathy is uncommon. Herein, we present a case of a 74-year-old woman with prominent neuropsychiatric symptoms followed by rapid cognitive decline. Extensive initial studies were nondiagnostic. Subsequently, serum N-type VGCC antibody was positive. After treatment with intravenous immunoglobulin, the patient's cognition and neuropsychiatric symptoms significantly improved.

Publication Date

4-1-2020

Publication Title

Proceedings (Baylor University. Medical Center)

ISSN

0899-8280

Volume

33

Issue

2

First Page

278

Last Page

280

PubMed ID

32313488

Digital Object Identifier (DOI)

10.1080/08998280.2019.1709117

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