Rapidly progressive dementia-associated N-type voltage-gated calcium channel antibody encephalopathy

Authors

Smathorn Thakolwiboon, Department of Neurology, Texas Tech University Health Sciences CenterLubbockTexas.
Amputch Karukote, Department of Neurology, Texas Tech University Health Sciences CenterLubbockTexas.
Gyeongmo Sohn, Department of Neurology, Texas Tech University Health Sciences CenterLubbockTexas.
Walter R. Duarte-Celada, Department of Neurology, Texas Tech University Health Sciences CenterLubbockTexas.
Parunyou Julayanont, Department of Neurology, Texas Tech University Health Sciences CenterLubbockTexas.

Document Type

Article

Abstract

Autoimmune encephalopathy is one of the treatable causes of rapidly progressive dementia; however, it is often underdiagnosed. Autoantibodies against voltage-gated calcium channel (VGCC) have been linked to several neurological disorders, including Lambert-Eaton syndrome, but VGCC antibody-associated encephalopathy is uncommon. Herein, we present a case of a 74-year-old woman with prominent neuropsychiatric symptoms followed by rapid cognitive decline. Extensive initial studies were nondiagnostic. Subsequently, serum N-type VGCC antibody was positive. After treatment with intravenous immunoglobulin, the patient's cognition and neuropsychiatric symptoms significantly improved.

Publication Date

4-1-2020

Publication Title

Proceedings (Baylor University. Medical Center)

ISSN

0899-8280

Volume

33

Issue

2

First Page

278

Last Page

280

PubMed ID

32313488

Digital Object Identifier (DOI)

10.1080/08998280.2019.1709117

Recommended Citation

Thakolwiboon, Smathorn; Karukote, Amputch; Sohn, Gyeongmo; Duarte-Celada, Walter R.; and Julayanont, Parunyou, "Rapidly progressive dementia-associated N-type voltage-gated calcium channel antibody encephalopathy" (2020). Neurology. 1245.
https://scholar.barrowneuro.org/neurology/1245