Epidermal growth factor receptor expression in demented and aged human brain
Immunoreactivity to epidermal growth factor receptor (EGFR) was present in the brain vasculature of13/13 demented elderly patients, but absent in9/11 non-demented elderly patients. Of the two positive non-demented patients, one had significant Alzheimer's pathology and the other spinal carcinoma. Ultrastructurally, EGFR is localized to the lumenal surface of endothelial cells. © 1990 Elsevier Science Publishers B. V. (Biomedical Division).
Alzheimer's disease, Endothelial cell, Epidermal growth factor, Epidermal growth factor receptor, Parkinson's disease
Digital Object Identifier (DOI)
Styren, Scot D.; Mufson, Elliot J.; Styren, Gisele C.; Harold Civin, W.; and Rogers, Joseph, "Epidermal growth factor receptor expression in demented and aged human brain" (1990). Translational Neuroscience. 1797.