Title

Epidermal growth factor receptor expression in demented and aged human brain

Document Type

Article

Abstract

Immunoreactivity to epidermal growth factor receptor (EGFR) was present in the brain vasculature of13/13 demented elderly patients, but absent in9/11 non-demented elderly patients. Of the two positive non-demented patients, one had significant Alzheimer's pathology and the other spinal carcinoma. Ultrastructurally, EGFR is localized to the lumenal surface of endothelial cells. © 1990 Elsevier Science Publishers B. V. (Biomedical Division).

Keywords

Alzheimer's disease, Endothelial cell, Epidermal growth factor, Epidermal growth factor receptor, Parkinson's disease

Publication Date

4-2-1990

Publication Title

Brain Research

ISSN

00068993

Volume

512

Issue

2

First Page

347

Last Page

352

PubMed ID

2354367

Digital Object Identifier (DOI)

10.1016/0006-8993(90)90647-T

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