Separated at birth? the functional and molecular divergence of OLIG1 and OLIG2
Document Type
Article
Abstract
The basic helix-loop-helix transcription factors oligodendrocyte transcription factor 1 (OLIG1) and OLIG2 are structurally similar and, to a first approximation, coordinately expressed in the developing CNS and postnatal brain. Despite these similarities, it was apparent from early on after their discovery that OLIG1 and OLIG2 have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes. Here, we summarize more recent insights into the separate roles of these transcription factors in the postnatal brain during repair processes and in neurological disease states, including multiple sclerosis and malignant glioma. We discuss how the unique functions of OLIG1 and OLIG2 may reflect their distinct genetic targets, co-regulator proteins and/or post-translational modifications. © 2012 Macmillan Publishers Limited. All rights reserved.
Publication Date
12-1-2012
Publication Title
Nature Reviews Neuroscience
ISSN
1471003X
E-ISSN
14710048
Volume
13
Issue
12
First Page
819
Last Page
831
PubMed ID
23165259
Digital Object Identifier (DOI)
10.1038/nrn3386
Recommended Citation
Meijer, Dimphna H.; Kane, Michael F.; Mehta, Shwetal; Liu, Hongye; Harrington, Emily; Taylor, Christopher M.; Stiles, Charles D.; and Rowitch, David H., "Separated at birth? the functional and molecular divergence of OLIG1 and OLIG2" (2012). Translational Neuroscience. 1602.
https://scholar.barrowneuro.org/neurobiology/1602