Manganese superoxide dismutase, MnSOD and its mimics
Document Type
Article
Abstract
Increased understanding of the role of mitochondria under physiological and pathological conditions parallels increased exploration of synthetic and natural compounds able to mimic MnSOD - endogenous mitochondrial antioxidant defense essential for the existence of virtually all aerobic organisms from bacteria to humans. This review describes most successful mitochondrially-targeted redox-active compounds, Mn porphyrins and MitoQ 10 in detail, and briefly addresses several other compounds that are either catalysts of O 2- dismutation, or its non-catalytic scavengers, and that reportedly attenuate mitochondrial dysfunction. While not a true catalyst (SOD mimic) of O 2- dismutation, MitoQ 10 oxidizes O 2- to O 2 with a high rate constant. In vivo it is readily reduced to quinol, MitoQH 2, which in turn reduces ONOO - to NO 2, producing semiquinone radical that subsequently dismutes to MitoQ 10 and MitoQH 2, completing the "catalytic" cycle. In MitoQ 10, the redox-active unit was coupled via 10-carbon atom alkyl chain to monocationic triphenylphosphonium ion in order to reach the mitochondria. Mn porphyrin-based SOD mimics, however, were designed so that their multiple cationic charge and alkyl chains determine both their remarkable SOD potency and carry them into the mitochondria. Several animal efficacy studies such as skin carcinogenesis and UVB-mediated mtDNA damage, and subcellular distribution studies of Saccharomyces cerevisiae and mouse heart provided unambiguous evidence that Mn porphyrins mimic the site and action of MnSOD, which in turn contributes to their efficacy in numerous in vitro and in vivo models of oxidative stress. Within a class of Mn porphyrins, lipophilic analogs are particularly effective for treating central nervous system injuries where mitochondria play key role. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease. © 2011 Elsevier B.V.
Keywords
MitoQ, Mn porphyrins, MnSOD, MnSOD mimics, MnTE-2-PyP, MnTnHex-2-PyP
Publication Date
5-1-2012
Publication Title
Biochimica et Biophysica Acta - Molecular Basis of Disease
ISSN
09254439
E-ISSN
1879260X
Volume
1822
Issue
5
First Page
794
Last Page
814
PubMed ID
22198225
Digital Object Identifier (DOI)
10.1016/j.bbadis.2011.12.002
Recommended Citation
Miriyala, Sumitra; Spasojevic, Ivan; Tovmasyan, Artak; Salvemini, Daniela; Vujaskovic, Zeljko; St. Clair, Daret; and Batinic-Haberle, Ines, "Manganese superoxide dismutase, MnSOD and its mimics" (2012). Translational Neuroscience. 1272.
https://scholar.barrowneuro.org/neurobiology/1272