Title

Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1

Document Type

Article

Abstract

The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.

Medical Subject Headings

Animals; Hippocampus (physiology); Ligands; Long-Term Potentiation (physiology); Long-Term Synaptic Depression (physiology); Mice; Mice, Transgenic; Neuronal Plasticity (physiology); Receptors, AMPA (metabolism); Synapses (metabolism); Synaptic Transmission (physiology); Tissue Distribution

Publication Date

8-1-2005

Publication Title

Nature neuroscience

ISSN

1097-6256

Volume

8

Issue

8

First Page

985

Last Page

7

PubMed ID

16007085

Digital Object Identifier (DOI)

10.1038/nn1432

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