Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1
The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.
Medical Subject Headings
Animals; Hippocampus (physiology); Ligands; Long-Term Potentiation (physiology); Long-Term Synaptic Depression (physiology); Mice; Mice, Transgenic; Neuronal Plasticity (physiology); Receptors, AMPA (metabolism); Synapses (metabolism); Synaptic Transmission (physiology); Tissue Distribution
Digital Object Identifier (DOI)
Kim, Chong-Hyun; Takamiya, Kogo; Petralia, Ronald S.; Sattler, Rita; Yu, Sandy; Zhou, Weiguo; Kalb, Robert; Wenthold, Robert; and Huganir, Richard, "Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1" (2005). Translational Neuroscience. 1373.