Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1

Authors

Chong-Hyun Kim, Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University, Baltimore, Maryland 21205, USA.
Kogo Takamiya
Ronald S. Petralia
Rita Sattler
Sandy Yu
Weiguo Zhou
Robert Kalb
Robert Wenthold
Richard Huganir

Document Type

Article

Abstract

The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.

Medical Subject Headings

Animals; Hippocampus (physiology); Ligands; Long-Term Potentiation (physiology); Long-Term Synaptic Depression (physiology); Mice; Mice, Transgenic; Neuronal Plasticity (physiology); Receptors, AMPA (metabolism); Synapses (metabolism); Synaptic Transmission (physiology); Tissue Distribution

Publication Date

8-1-2005

Publication Title

Nature neuroscience

ISSN

1097-6256

Volume

8

Issue

8

First Page

985

Last Page

7

PubMed ID

16007085

Digital Object Identifier (DOI)

10.1038/nn1432

Recommended Citation

Kim, Chong-Hyun; Takamiya, Kogo; Petralia, Ronald S.; Sattler, Rita; Yu, Sandy; Zhou, Weiguo; Kalb, Robert; Wenthold, Robert; and Huganir, Richard, "Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1" (2005). Translational Neuroscience. 1373.
https://scholar.barrowneuro.org/neurobiology/1373