Flow residence time and regions of intraluminal thrombus deposition in intracranial aneurysms

Authors

V. L. Rayz, University of California, San Francisco
L. Boussel, Hopital Louis Pradel
L. Ge, University of California, San Francisco
J. R. Leach, University of California, Berkeley
A. J. Martin, University of California, San Francisco
M. T. Lawton, University of California, San FranciscoFollow
C. McCulloch, University of California, San Francisco
D. Saloner, University of California, San Francisco

Document Type

Article

Abstract

Thrombus formation in intracranial aneurysms, while sometimes stabilizing lesion growth, can present additional risk of thrombo-embolism. The role of hemodynamics in the progression of aneurysmal disease can be elucidated by patient-specific computational modeling. In our previous work, patient-specific computational fluid dynamics (CFD) models were constructed from MRI data for three patients who had fusiform basilar aneurysms that were thrombus-free and then proceeded to develop intraluminal thrombus. In this study, we investigated the effect of increased flow residence time (RT) by modeling passive scalar advection in the same aneurysmal geometries. Non-Newtonian pulsatile flow simulations were carried out in base-line geometries and a new postprocessing technique, referred to as "virtual ink" and based on the passive scalar distribution maps, was used to visualize the flow and estimate the flow RT. The virtual ink technique clearly depicted regions of flow separation. The flow RT at different locations adjacent to aneurysmal walls was calculated as the time the virtual ink scalar remained above a threshold value. The RT values obtained in different areas were then correlated with the location of intra-aneurysmal thrombus observed at a follow-up MR study. For each patient, the wall shear stress (WSS) distribution was also obtained from CFD simulations and correlated with thrombus location. The correlation analysis determined a significant relationship between regions where CFD predicted either an increased RT or low WSS and the regions where thrombus deposition was observed to occur in vivo. A model including both low WSS and increased RT predicted thrombus-prone regions significantly better than the models with RT or WSS alone. © 2010 The Author(s).

Publication Date

10-1-2010

Publication Title

Annals of Biomedical Engineering

ISSN

00906964

E-ISSN

15739686

Volume

38

Issue

10

First Page

3058

Last Page

3069

PubMed ID

20499185

Digital Object Identifier (DOI)

10.1007/s10439-010-0065-8

Recommended Citation

Rayz, V. L.; Boussel, L.; Ge, L.; Leach, J. R.; Martin, A. J.; Lawton, M. T.; McCulloch, C.; and Saloner, D., "Flow residence time and regions of intraluminal thrombus deposition in intracranial aneurysms" (2010). Neurosurgery. 995.
https://scholar.barrowneuro.org/neurosurgery/995