Cerebral vasospasm after subarachnoid hemorrhage: Putative role of inflammation

Authors

Aaron S. Dumont, University of Virginia School of Medicine
Randall J. Dumont, University of Virginia School of Medicine
Michael M. Chow, University of Virginia School of Medicine
Chi lung Lin, University of Virginia School of Medicine
Tarkan Calisaneller, University of Virginia School of Medicine
Klaus F. Ley, University of Virginia School of Medicine
Neal F. Kassell, University of Virginia School of Medicine
Kevin S. Lee, University of Virginia School of Medicine
Daniel L. Barrow
R. Loch Macdonald
Brian L. Hoh
Christopher S. Ogilvy
Michael T. LawtonFollow

Document Type

Article

Abstract

Cerebral vasospasm is a common, formidable, and potentially devastating complication in patients who have sustained subarachnoid hemorrhage (SAH). Despite intensive research efforts, cerebral vasospasm remains incompletely understood from both the pathogenic and therapeutic perspectives. At present, no consistently efficacious and ubiquitously applied preventive and therapeutic measures are available in clinical practice. Recently, convincing data have implicated a role of inflammation in the development and maintenance of cerebral vasospasm. A burgeoning (although incomplete) body of evidence suggests that various constituents of the inflammatory response, including adhesion molecules, cytokines, leukocytes, immunoglobulins, and complement, may be critical in the pathogenesis of cerebral vasospasm. Recent studies attempting to dissect the cellular and molecular basis of the inflammatory response accompanying SAH and cerebral vasospasm have provided a promising groundwork for future studies. It is plausible that the inflammatory response may indeed represent a critical common pathway in the pathogenesis of cerebral vasospasm pursuant to SAH. Investigations into the nature of the inflammatory response accompanying SAH are needed to elucidate the precise role(s) of inflammatory events in SAH-induced pathologies.

Publication Date

7-1-2003

Publication Title

Neurosurgery

ISSN

0148396X

Volume

53

Issue

1

First Page

123

Last Page

135

PubMed ID

12823881

Digital Object Identifier (DOI)

10.1227/01.NEU.0000068863.37133.9E

Recommended Citation

Dumont, Aaron S.; Dumont, Randall J.; Chow, Michael M.; Lin, Chi lung; Calisaneller, Tarkan; Ley, Klaus F.; Kassell, Neal F.; Lee, Kevin S.; Barrow, Daniel L.; Macdonald, R. Loch; Hoh, Brian L.; Ogilvy, Christopher S.; and Lawton, Michael T., "Cerebral vasospasm after subarachnoid hemorrhage: Putative role of inflammation" (2003). Neurosurgery. 866.
https://scholar.barrowneuro.org/neurosurgery/866