Stem Cell Biology and Its Therapeutic Applications in the Setting of Spinal Cord Injury

Authors

Nicholas C. BambakidisFollow
John Butler
Eric M. Horn
Xukui Wang
Mark C. PreulFollow
Nicholas TheodoreFollow
Robert F. Spetzler, Barrow Neurological InstituteFollow
Volker K.H. Sonntag, Barrow Neurological InstituteFollow

Department

neurosurgery

Document Type

Article

Abstract

The development of an acute traumatic spinal cord injury (SCI) inevitably leads to a complex cascade of ischemia and inflammation that results in significant scar tissue formation. The development of such scar tissue provides a severe impediment to neural regeneration and healing with restoration of function. A multimodal approach to treatment is required because SCIs occur with differing levels of severity and over different lengths of time. To achieve significant breakthroughs in outcomes, such approaches must combine both neuroprotective and neuroregenerative treatments. Novel techniques modulating endogenous stem cells demonstrate great promise in promoting neuroregeneration and restoring function.

Publication Date

2008

Publication Title

Neurosurgical Focus

ISSN

1092-0684

Volume

24

Issue

43528

Digital Object Identifier (DOI)

10.3171/FOC/2008/24/3-4/E18

Recommended Citation

Bambakidis, Nicholas C.; Butler, John; Horn, Eric M.; Wang, Xukui; Preul, Mark C.; Theodore, Nicholas; Spetzler, Robert F.; and Sonntag, Volker K.H., "Stem Cell Biology and Its Therapeutic Applications in the Setting of Spinal Cord Injury" (2008). Neurosurgery. 390.
https://scholar.barrowneuro.org/neurosurgery/390