Safety of Carotid Endarterectomy While on Clopidogrel (Plavix): Clinical Article

Department

neurosurgery

Document Type

Article

Abstract

Object. Many patients undergoing carotid endarterectomy (CEA) regularly take clopidogrel, a permanent platelet inhibitor. The authors sought to determine whether taking clopidogrel in the period before CEA leads to more bleeding or other complications. Methods. The authors performed a retrospective, institutional review board - approved review of 182 consecutive patients who underwent CEA. Clinical, radiographic, and surgical data were gleaned from hospital and clinic records. Analysis was based on the presence or absence of clopidogrel in patients undergoing CEA and was performed twice by considering clopidogrel use within 8 days and within 5 days of surgery to define the groups. Results. Taking clopidogrel within 8 days before surgery resulted in no statistical increase in any measure of morbidity or death. Taking clopidogrel within 5 days was associated with a small but significant increase in operative blood loss and conservatively managed postoperative neck swelling. No measure of permanent morbidity or death was increased in either clopidogrel group. Conclusions. Findings in this study support the safety of preoperative clopidogrel in patients undergoing CEA.

Publication Date

2010

Publication Title

Journal of Neurosurgery

ISSN

0022-3085

Volume

113

Issue

4

First Page

908

Last Page

912

Digital Object Identifier (DOI)

10.3171/2009.12.JNS09707

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