Trim71/lin-41 Links an Ancient miRNA Pathway to Human Congenital Hydrocephalus

Authors

• Phan Q. Duy, Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA; Medical Scientist Training Program, Yale University School of Medicine, New Haven, CT, USA.
• Charuta G. Furey, Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.
• Kristopher T. Kahle, Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA; Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA; Yale-Rockefeller NIH Centers for Mendelian Genomics, Yale University, New Haven, CT, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA. Electronic address: [email protected].

Document Type

Article

Abstract

Tripartite motif 71 (Trim71)/lineage defective 41 (lin-41) is the primary target of the ancient lethal 7 (let-7) miRNA that is essential for survival and development across animal phylogeny. Recent work identified Trim71 as a critical regulator of mammalian neural stem cell (NSC) fate and a bona fide human disease gene in congenital hydrocephalus (CH). Studying TRIM71 as a paradigm of NSC involvement in CH is a remarkable opportunity to better understand the mechanisms that regulate the timing of brain development and the pathogenesis of the most common pediatric neurosurgical disorder.

Medical Subject Headings

Brain (abnormalities, embryology, metabolism); Genetic Predisposition to Disease; Humans; Hydrocephalus (diagnosis, genetics); MicroRNAs (genetics); Neural Stem Cells (metabolism); Neurogenesis (genetics); Transcription Factors (genetics); Tripartite Motif Proteins (genetics); Ubiquitin-Protein Ligases (genetics)

Publication Date

6-1-2019

Publication Title

Trends in molecular medicine

E-ISSN

1471-499X

Volume

25

Issue

6

First Page

467

Last Page

469

PubMed ID

30975633

Digital Object Identifier (DOI)

10.1016/j.molmed.2019.03.004

Recommended Citation

Duy, Phan Q.; Furey, Charuta G.; and Kahle, Kristopher T., "Trim71/lin-41 Links an Ancient miRNA Pathway to Human Congenital Hydrocephalus" (2019). Neurosurgery. 2414.
https://scholar.barrowneuro.org/neurosurgery/2414