The effects of hyperglycemia on outcomes in surgical high-grade glioma patients

Authors

• Matthew Decker, Lillian S. Wells Department of Neurosurgery, 1600 S.W. Archer Road, University of Florida, Gainesville, FL, 32608, United States. Electronic address: madecker@ufl.edu.
• Patricia Sacks, Lillian S. Wells Department of Neurosurgery, 1600 S.W. Archer Road, University of Florida, Gainesville, FL, 32608, United States.
• Joseph Abbatematteo, Lillian S. Wells Department of Neurosurgery, 1600 S.W. Archer Road, University of Florida, Gainesville, FL, 32608, United States.Follow
• Edward De Leo, Lillian S. Wells Department of Neurosurgery, 1600 S.W. Archer Road, University of Florida, Gainesville, FL, 32608, United States.
• Meghan Brennan, Lillian S. Wells Department of Neurosurgery, 1600 S.W. Archer Road, University of Florida, Gainesville, FL, 32608, United States.
• Maryam Rahman, Lillian S. Wells Department of Neurosurgery, 1600 S.W. Archer Road, University of Florida, Gainesville, FL, 32608, United States.

Document Type

Article

Abstract

OBJECTIVE: To define the glucose values associated with an increase in complication rates in post-operative brain tumor patients. PATIENTS AND METHODS: Patients who underwent craniotomy for resection of WHO Grade III or IV glioma from 2011 to 2014 were retrospectively reviewed. Post-operative blood glucose values were recorded for post-operative day #0, #1, and #2. Medians were obtained and assessed for significance. Multivariate analysis was performed to assess patient demographics, pre-operative findings, steroid use, and blood glucose values with respect to post-operative complications and to 30-day readmission. RESULTS: 108 patients underwent craniotomy for resection of high-grade glioma and had postoperative blood glucose values documented. Median blood glucose values greater than 167 mg/dL were associated with increased serious post-operative complications, and values greater than 163 mg/dL were associated with increased 30-day readmissions. CONCLUSION: Post-operative hyperglycemia in patients with high-grade gliomas places this vulnerable patient population to undue post-operative complications and readmissions, potentially delaying further treatment of their disease.

Medical Subject Headings

Adult; Aged; Aged, 80 and over; Blood Glucose (analysis); Brain Neoplasms (complications, diagnostic imaging, surgery); Craniotomy; Female; Glioma (complications, diagnostic imaging, surgery); Humans; Hyperglycemia (complications, diagnostic imaging); Magnetic Resonance Imaging; Male; Middle Aged; Patient Readmission; Postoperative Complications (epidemiology); Retrospective Studies; Steroids (therapeutic use); Treatment Outcome; Young Adult

Publication Date

4-1-2019

Publication Title

Clinical neurology and neurosurgery

E-ISSN

1872-6968

Volume

179

First Page

9

Last Page

13

PubMed ID

30784896

Digital Object Identifier (DOI)

10.1016/j.clineuro.2019.02.011

Recommended Citation

Decker, Matthew; Sacks, Patricia; Abbatematteo, Joseph; De Leo, Edward; Brennan, Meghan; and Rahman, Maryam, "The effects of hyperglycemia on outcomes in surgical high-grade glioma patients" (2019). Neurosurgery. 2389.
https://scholar.barrowneuro.org/neurosurgery/2389