Multinodular and vacuolating neuronal tumor in the thalamus: case report and systematic review of literature

Authors

• Thomas J. On, Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
• Oscar Alcantar-Garibay, Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
• Yuan Xu, Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
• Irakliy Abramov, Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
• Jennifer M. Eschbacher, Department of Neuropathology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
• Nishant Tiwari, Department of Neuropathology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
• Kris A. Smith, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
• Mark C. Preul, Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. mark.preul@barrowneuro.org.

Document Type

Article

Abstract

The authors present the first reported case of MVNT in the thalamus in a 60-year-old man with a 20-year history of epilepsy and recent progressive neurological decline presented for neurosurgical evaluation for a non-enhancing mass predominantly in the right thalamus presumed to be a low-grade glioma. The tumor was subtotally resected using a left contralateral interhemispheric transcallosal approach. Histological and molecular assessment revealed an MVNT with MAPK pathway-activating mutation. The authors also conducted a systematic review of pathology-proven cases of MVNT to provide an up-to-date overview of the literature on the localization, presenting symptoms, and recurrence of this tumor.

Medical Subject Headings

Humans; Male; Middle Aged; Brain Neoplasms (surgery, pathology, diagnostic imaging); Glioma (surgery, pathology, diagnostic imaging); Thalamus (pathology, surgery, diagnostic imaging); Diagnosis, Differential

Publication Date

8-19-2024

Publication Title

Acta neurochirurgica

E-ISSN

0942-0940

Volume

166

Issue

1

First Page

340

PubMed ID

39160266

Digital Object Identifier (DOI)

10.1007/s00701-024-06230-8

Recommended Citation

On, Thomas J.; Alcantar-Garibay, Oscar; Xu, Yuan; Abramov, Irakliy; Eschbacher, Jennifer M.; Tiwari, Nishant; Smith, Kris A.; and Preul, Mark C., "Multinodular and vacuolating neuronal tumor in the thalamus: case report and systematic review of literature" (2024). Neurosurgery. 2341.
https://scholar.barrowneuro.org/neurosurgery/2341