Intraoperative Fluorescent Imaging of Intracranial Tumors: A Review

Department

neurosurgery

Document Type

Article

Abstract

A review of fluorescent imaging for intracranial neoplasms is presented. Complete resection of brain cancer is seldom possible because of the goal to preserve brain tissue and the inability to visualize individual infiltrative tumor cells. Verification of histology and identification of tumor invasion in macroscopically normal-appearing brain tissue determine prognosis after resection of malignant gliomas. Therefore, imaging modalities aim to facilitate intraoperative decision-making. Intraoperative fluorescent imaging techniques have the potential to enable precise histopathologic diagnosis and to detect tumor remnants in the operative field. Macroscopic fluorescence imaging is effective for gross tumor detection. Microscopic imaging techniques enhance the sensitivity of the macroscopic observations and provide real-time histological information. Further development of clinical grade fluorescent agents specifically targeting tumor cells could improve the diagnostic and prognostic yield of intraoperative imaging. © 2013 Elsevier B.V.

Publication Date

2013

Publication Title

Clinical Neurology and Neurosurgery

ISSN

0303-8467

Volume

115

Issue

5

First Page

517

Last Page

528

Digital Object Identifier (DOI)

10.1016/j.clineuro.2013.02.019

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