Deep learning in neurosurgery: a systematic literature review with a structured analysis of applications across subspecialties

Authors

Kivanc Yangi, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Jinpyo Hong, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Arianna S. Gholami, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Thomas J. On, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Alexander G. Reed, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Pravarakhya Puppalla, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Jiuxu Chen, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Carlos E. Calderon Valero, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Yuan Xu, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Baoxin Li, School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, United States.
Marco Santello, School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States.
Michael T. Lawton, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Mark C. Preul, The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.

Document Type

Article

Abstract

OBJECTIVE: This study systematically reviewed deep learning (DL) applications in neurosurgical practice to provide a comprehensive understanding of DL in neurosurgery. The review process included a systematic overview of recent developments in DL technologies, an examination of the existing literature on their applications in neurosurgery, and insights into the future of neurosurgery. The study also summarized the most widely used DL algorithms, their specific applications in neurosurgical practice, their limitations, and future directions. MATERIALS AND METHODS: An advanced search using medical subject heading terms was conducted in Medline (via PubMed), Scopus, and Embase databases restricted to articles published in English. Two independent neurosurgically experienced reviewers screened selected articles. RESULTS: A total of 456 articles were initially retrieved. After screening, 162 were found eligible and included in the study. Reference lists of all 162 articles were checked, and 19 additional articles were found eligible and included in the study. The 181 included articles were divided into 6 categories according to the subspecialties: general neurosurgery (n = 64), neuro-oncology (n = 49), functional neurosurgery (n = 32), vascular neurosurgery (n = 17), neurotrauma (n = 9), and spine and peripheral nerve (n = 10). The leading procedures in which DL algorithms were most commonly used were deep brain stimulation and subthalamic and thalamic nuclei localization (n = 24) in the functional neurosurgery group; segmentation, identification, classification, and diagnosis of brain tumors (n = 29) in the neuro-oncology group; and neuronavigation and image-guided neurosurgery (n = 13) in the general neurosurgery group. Apart from various video and image datasets, computed tomography, magnetic resonance imaging, and ultrasonography were the most frequently used datasets to train DL algorithms in all groups overall (n = 79). Although there were few studies involving DL applications in neurosurgery in 2016, research interest began to increase in 2019 and has continued to grow in the 2020s. CONCLUSION: DL algorithms can enhance neurosurgical practice by improving surgical workflows, real-time monitoring, diagnostic accuracy, outcome prediction, volumetric assessment, and neurosurgical education. However, their integration into neurosurgical practice involves challenges and limitations. Future studies should focus on refining DL models with a wide variety of datasets, developing effective implementation techniques, and assessing their affect on time and cost efficiency.

Publication Date

1-1-2025

Publication Title

Frontiers in neurology

ISSN

1664-2295

Volume

16

First Page

1532398

PubMed ID

40308224

Digital Object Identifier (DOI)

10.3389/fneur.2025.1532398

Recommended Citation

Yangi, Kivanc; Hong, Jinpyo; Gholami, Arianna S.; On, Thomas J.; Reed, Alexander G.; Puppalla, Pravarakhya; Chen, Jiuxu; Calderon Valero, Carlos E.; Xu, Yuan; Li, Baoxin; Santello, Marco; Lawton, Michael T.; and Preul, Mark C., "Deep learning in neurosurgery: a systematic literature review with a structured analysis of applications across subspecialties" (2025). Neurosurgery. 2255.
https://scholar.barrowneuro.org/neurosurgery/2255