The many roles of microRNAs in brain tumor biology.
Document Type
Article
Abstract
MicroRNAs (miRNAs) are now recognized as the primary RNAs involved in the purposeful silencing of the cell's own message. In addition to the established role of miRNAs as developmental regulators of normal cellular function, they have recently been shown to be important players in pathological states such as cancer. The authors review the literature on the role of miRNAs in the formation and propagation of gliomas and medulloblastomas, highlighting the potential of these molecules and their inhibitors as therapeutics.
Medical Subject Headings
Biomarkers, Tumor; Brain Neoplasms; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioma; Humans; Medulloblastoma; MicroRNAs; Neurogenesis
Publication Date
1-1-2010
Publication Title
Neurosurgical focus [electronic resource]
ISSN
1092-0684
Volume
28
Issue
1
First Page
3
Last Page
3
PubMed ID
20043718
Digital Object Identifier (DOI)
10.3171/2009.10.FOCUS09207
Recommended Citation
Turner, Jay D; Williamson, Richard; Almefty, Kaith K; Nakaji, Peter; Porter, Randall; Tse, Victor; and Kalani, M Yashar S, "The many roles of microRNAs in brain tumor biology." (2010). Neurosurgery. 2087.
https://scholar.barrowneuro.org/neurosurgery/2087