WarpDrive: Improving spatial normalization using manual refinements.
Document Type
Article
Abstract
Spatial normalization-the process of mapping subject brain images to an average template brain-has evolved over the last 20+ years into a reliable method that facilitates the comparison of brain imaging results across patients, centers & modalities. While overall successful, sometimes, this automatic process yields suboptimal results, especially when dealing with brains with extensive neurodegeneration and atrophy patterns, or when high accuracy in specific regions is needed. Here we introduce WarpDrive, a novel tool for manual refinements of image alignment after automated registration. We show that the tool applied in a cohort of patients with Alzheimer's disease who underwent deep brain stimulation surgery helps create more accurate representations of the data as well as meaningful models to explain patient outcomes. The tool is built to handle any type of 3D imaging data, also allowing refinements in high-resolution imaging, including histology and multiple modalities to precisely aggregate multiple data sources together.
Medical Subject Headings
Humans; Image Processing, Computer-Assisted; Brain; Imaging, Three-Dimensional; Brain Mapping; Alzheimer Disease; Magnetic Resonance Imaging
Publication Date
1-1-2024
Publication Title
Medical image analysis
ISSN
1361-8423
Volume
91
First Page
103041
Last Page
103041
PubMed ID
38007978
Digital Object Identifier (DOI)
10.1016/j.media.2023.103041
Recommended Citation
Oxenford, Simón; Ríos, Ana Sofía; Hollunder, Barbara; Neudorfer, Clemens; Boutet, Alexandre; Elias, Gavin J B; Germann, Jurgen; Loh, Aaron; Deeb, Wissam; Salvato, Bryan; Almeida, Leonardo; Foote, Kelly D; Amaral, Robert; Rosenberg, Paul B; Tang-Wai, David F; Wolk, David A; Burke, Anna D; Sabbagh, Marwan N; Salloway, Stephen; Chakravarty, M Mallar; Smith, Gwenn S; Lyketsos, Constantine G; Okun, Michael S; Anderson, William S; Mari, Zoltan; Ponce, Francisco A; Lozano, Andres; Neumann, Wolf-Julian; Al-Fatly, Bassam; and Horn, Andreas, "WarpDrive: Improving spatial normalization using manual refinements." (2024). Neurosurgery. 2081.
https://scholar.barrowneuro.org/neurosurgery/2081