Microsurgical treatment of pediatric intracranial aneurysms: long-term angiographic and clinical outcomes.

Document Type

Article

Abstract

BACKGROUND: Pediatric aneurysms are rare and complex to treat. Long-term angiographic and clinical data after microsurgical or endovascular therapies are lacking.

OBJECTIVE: To study the clinical and radiographic outcomes in aneurysms in pediatric patients treated with microsurgery.

METHODS: Between 1989 and 2005, 48 patients

RESULTS: Seventy-two aneurysms were treated. Presentations included incidental aneurysm (35%), aneurysmal subarachnoid hemorrhage (17%), stroke (13%), and traumatic subarachnoid hemorrhage (10%). Location was anterior circulation in 76% and posterior circulation in 24%. Twenty-eight (39%) were fusiform/dissecting, and 16 (23%) were giant. Most aneurysms were clipped directly. A vascular bypass with parent-vessel occlusion was used to treat 13 aneurysms (18%). Hypothermic circulatory arrest was used to treat 10 aneurysms (14%), all involving the basilar artery. The perioperative morbidity rate was 25%. There were no deaths. The long-term morbidity rate was 14%, and the mortality rate was 3%. Clinical outcome was favorable in 92% and 94% at discharge and follow-up, respectively (mean, 59 months; median, 32 months). At angiographic follow-up (mean, 53 months; median, 32 months), the annual recurrence rate was 2.6%, and the annual rate of de novo formation or growth was 7.8%.

CONCLUSION: Pediatric aneurysms require complex microsurgical techniques to achieve favorable outcomes. They leave higher rates of recurrence and de novo formation or growth than their adult counterparts, which mandates lifelong follow-up.

Medical Subject Headings

Accidents, Traffic; Adolescent; Age Factors; Aortic Dissection; Cerebral Angiography; Child; Child, Preschool; Craniocerebral Trauma; Databases, Factual; Female; Glasgow Outcome Scale; Humans; Infant; Intracranial Aneurysm; Male; Microsurgery; Nervous System Diseases; Neurosurgical Procedures; Pregnancy; Prospective Studies; Recurrence; Sex Factors; Treatment Outcome

Publication Date

8-1-2010

Publication Title

Neurosurgery

ISSN

1524-4040

Volume

67

Issue

2

First Page

237

Last Page

249

PubMed ID

20539250

Digital Object Identifier (DOI)

10.1227/01.NEU.0000371727.71991.64

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