Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report

Authors

Maryam N. Shahin, Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, United States.
Stephen G. Bowden, Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, United States.
Nasser K. Yaghi, Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, United States.
Jacob H. Bagley, Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, United States.
Seunggu J. Han, Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, United States.
Elena V. Varlamov, Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, United States.
Marjorie R. Grafe, Department of Pathology, Oregon Health & Science University, Portland, Oregon, United States.
Justin S. Cetas, Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, United States.

Document Type

Article

Abstract

Meningiomas are more common in females and frequently express progesterone and estrogen receptors. Recent studies have revealed a high incidence of meningiomas in situations in which estrogen/progesterone levels are increased such as pregnancy, gender reassignment therapy, and fertility treatment. While the relationship remains unclear and controversial, these findings suggest exposure to high levels of endogenous or exogenous hormones may increase the risk of developing a meningioma.  A 40-year-old female with a history of endometriosis treated with chronic progesterone therapy presented with a visual deficit and was found to have multiple meningiomas, which regressed after cessation of exogenous progesterone.  A history of chronic hormone therapy should be included when evaluating patients diagnosed with meningiomas, particularly at a younger age and with multiple meningiomas. Cessation of exogenous progesterone resulting in regression of meningiomas suggests a direct action of progesterone on growth. Future studies are warranted to better elucidate this relationship.

Publication Date

10-1-2021

Publication Title

Journal of neurological surgery reports

ISSN

2193-6358

Volume

82

Issue

4

First Page

e38

Last Page

e42

PubMed ID

34877245

Digital Object Identifier (DOI)

10.1055/s-0041-1735553

Recommended Citation

Shahin, Maryam N.; Bowden, Stephen G.; Yaghi, Nasser K.; Bagley, Jacob H.; Han, Seunggu J.; Varlamov, Elena V.; Grafe, Marjorie R.; and Cetas, Justin S., "Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report" (2021). Neurosurgery. 1931.
https://scholar.barrowneuro.org/neurosurgery/1931