Von hippel-lindau disease associated pulmonary carcinoid with cranial metastasis

Authors

Chao Zhang, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (C.Z., A.I.Y., C.Y., C.L.N., P.C., J.D.H., Z.Z., K.A.Z.), and Laboratory of Pathology, National Cancer Institute (L.V., S.M., L.S., Z.A., S.D.P., A.G., M.M.Q.), National Institutes of Health, Bethesda, Maryland 20892; and Department of Orthopedics (C.Z.), Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China.
Andrew I. Yang
Lucas Vasconcelos
Seog Moon
Chunzhang Yang
Cody L. Nesvick
Lola Saidkhodjaeva
Ziedulla Abdullaev
Svetlana D. Pack
Arunima Ghosh
Prashant Chittiboina
John D. Heiss
Zhengping Zhuang
Martha M. Quezado
Kareem A. Zaghloul

Document Type

Article

Abstract

CONTEXT: Carcinoids have rarely been described in von Hippel-Lindau (VHL) disease. OBJECTIVE: We describe the first reported case of a patient with VHL who developed a pulmonary carcinoid that subsequently metastasized to a pre-existent cranial hemangioblastoma. RESULTS: Histological and immunohistochemical features of the metastatic lesion were similar to the primary carcinoid. Both lesions demonstrated heterozygous VHL gene deletions with fluorescence in situ hybridization analysis. CONCLUSIONS: This case provides direct molecular genetic evidence of an association between VHL and carcinoids.

Medical Subject Headings

Adult; Brain Neoplasms (diagnosis, pathology); Carcinoid Tumor (diagnosis, etiology, pathology); Hemangioblastoma (diagnosis, pathology); Humans; Lung Neoplasms (diagnosis, etiology, pathology); Lymphatic Metastasis; Male; Neoplasms, Second Primary (diagnosis, pathology); von Hippel-Lindau Disease (complications, diagnosis)

Publication Date

8-1-2014

Publication Title

The Journal of clinical endocrinology and metabolism

E-ISSN

1945-7197

Volume

99

Issue

8

First Page

2633

Last Page

6

PubMed ID

24878057

Digital Object Identifier (DOI)

10.1210/jc.2014-1732

Recommended Citation

Zhang, Chao; Yang, Andrew I.; Vasconcelos, Lucas; Moon, Seog; Yang, Chunzhang; Nesvick, Cody L.; Saidkhodjaeva, Lola; Abdullaev, Ziedulla; Pack, Svetlana D.; Ghosh, Arunima; Chittiboina, Prashant; Heiss, John D.; Zhuang, Zhengping; Quezado, Martha M.; and Zaghloul, Kareem A., "Von hippel-lindau disease associated pulmonary carcinoid with cranial metastasis" (2014). Neurosurgery. 1891.
https://scholar.barrowneuro.org/neurosurgery/1891