Multifocal dysembryoplastic neuroepithelial tumours associated with refractory epilepsy

Authors

Andrew I. Yang, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda.
Ayaz M. Khawaja, Department of Neurology, University of Alabama at Birmingham, Birmingham.
Leo Ballester-Fuentes, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda.
Svetlana D. Pack, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda.
Ziedulla Abdullaev, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda.
Nicholas J. Patronas, Section of Neuroradiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda.
Sara K. Inati, EEG Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda.
William H. Theodore, Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Martha M. Quezado, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda.
Kareem A. Zaghloul, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda.

Document Type

Article

Abstract

Dysembryoplastic neuroepithelial tumours (DNET) are a common cause of tumour-associated epilepsy, and are usually located in the temporal lobes. We present a case of multifocal DNETs in both infra- and supra-tentorial locations, in a 23-year-old man with a coincident Type I Chiari malformation, presenting with medically refractory focal seizures. The extensive anatomical distribution of the lesions suggests a genetic component in their tumourigenesis.

Medical Subject Headings

Brain Neoplasms (complications, pathology); Epilepsy (etiology, pathology); Humans; Male; Neoplasms, Neuroepithelial (complications, pathology); Seizures (etiology, pathology); Temporal Lobe (pathology); Young Adult

Publication Date

9-1-2014

Publication Title

Epileptic disorders : international epilepsy journal with videotape

ISSN

1294-9361

Volume

16

Issue

3

First Page

328

Last Page

32

PubMed ID

25204011

Digital Object Identifier (DOI)

10.1684/epd.2014.0680

Recommended Citation

Yang, Andrew I.; Khawaja, Ayaz M.; Ballester-Fuentes, Leo; Pack, Svetlana D.; Abdullaev, Ziedulla; Patronas, Nicholas J.; Inati, Sara K.; Theodore, William H.; Quezado, Martha M.; and Zaghloul, Kareem A., "Multifocal dysembryoplastic neuroepithelial tumours associated with refractory epilepsy" (2014). Neurosurgery. 1877.
https://scholar.barrowneuro.org/neurosurgery/1877