Management and outcomes following emergency surgery for traumatic brain injury - A multi-centre, international, prospective cohort study (the Global Neurotrauma Outcomes Study)

David Clark, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Alexis Joannides, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Omar Ibrahim Abdallah, Sohag University Hospitals, Sohag, Egypt.
Amos Olufemi Adeleye, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Abdul Hafid Bajamal, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Tom Bashford, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Arnold Bhebhe, University Teaching Hospital, Lusaka, Zambia.
Hagos Biluts, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Natalia Budohoska, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Karol Budohoski, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Iype Cherian, Nobel Medical College Teaching Hospital P Ltd, Biratnagar, Morang, Nepal.
Niklas Marklund, Lund University, Skane University Hospital, Lund, Sweden.
Rocio Fernandez Mendez, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom.
Tony Figaji, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Deepak Kumar Gupta, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Corrado Iaccarino, University Hospital of Parma, Parma, Emilia-Romagna, Italy.
Ali Ilunga, University Teaching Hospital, Lusaka, Zambia.
Mathew Joseph, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Tariq Khan, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Tsegazeab Laeke, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Vicknes Waran, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Kee Park, Harvard Medical School, Boston, MA, USA.
Gail Rosseau, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Andres Rubiano, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Youssuf Saleh, University of Oxford, Oxford, Oxfordshire, United Kingdom.
Hamisi K. Shabani, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Brandon Smith, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Kachinga Sichizya, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Manoj Tewari, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Abenezer Tirsit, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Myat Thu, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Manjul Tripathi, National Institute of Health Research Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.

Document Type

Article

Abstract

INTRODUCTION: Traumatic brain injury (TBI) accounts for a significant amount of death and disability worldwide and the majority of this burden affects individuals in low-and-middle income countries. Despite this, considerable geographical differences have been reported in the care of TBI patients. On this background, we aim to provide a comprehensive international picture of the epidemiological characteristics, management and outcomes of patients undergoing emergency surgery for traumatic brain injury (TBI) worldwide. METHODS AND ANALYSIS: The Global Neurotrauma Outcomes Study (GNOS) is a multi-centre, international, prospective observational cohort study. Any unit performing emergency surgery for TBI worldwide will be eligible to participate. All TBI patients who receive emergency surgery in any given consecutive 30-day period beginning between 1st of November 2018 and 31st of December 2019 in a given participating unit will be included. Data will be collected via a secure online platform in anonymised form. The primary outcome measures for the study will be 14-day mortality (or survival to hospital discharge, whichever comes first). Final day of data collection for the primary outcome measure is February 13th. Secondary outcome measures include return to theatre and surgical site infection. ETHICS AND DISSEMINATION: This project will not affect clinical practice and has been classified as clinical audit following research ethics review. Access to source data will be made available to collaborators through national or international anonymised datasets on request and after review of the scientific validity of the proposed analysis by the central study team.

Publication Date

1-1-2020

Publication Title

International journal of surgery protocols

E-ISSN

2468-3574

Volume

20

First Page

1

Last Page

7

PubMed ID

32211566

Digital Object Identifier (DOI)

10.1016/j.isjp.2020.02.001

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