Genomic expression discovery predicts pathways and opposing functions behind phenotypes
Document Type
Article
Abstract
Discovering states of genetic expression that are true to a high degree of certainty is likely to predict gene function behind biological phenotypes. The states of expression (up- or down-regulated) of 19200 cDNAs in 10 meningiomas are compared with normal brain by an algorithm that detects only 1 false measurement per 192000; 364 genes are discovered. The expression data accurately predict activation of signaling pathways and link gene function to specific phenotypes. Meningiomas appear to acquire aberrant phenotypes by disturbing the balanced expression of molecules that promote opposing functions. The findings expose interconnected genes and propose a role of genomic expression discovery in functional genomics of living systems.
Medical Subject Headings
Algorithms; Brain (metabolism, pathology); Case-Control Studies; Gene Expression Profiling (methods); Gene Expression Regulation; Humans; Meningioma (genetics); Oligonucleotide Array Sequence Analysis; Phenotype; RNA, Neoplasm (analysis); Signal Transduction
Publication Date
6-27-2003
Publication Title
The Journal of biological chemistry
ISSN
0021-9258
Volume
278
Issue
26
First Page
23830
Last Page
3
PubMed ID
12700229
Digital Object Identifier (DOI)
10.1074/jbc.M302800200
Recommended Citation
Fathallah-Shaykh, Hassan M.; He, Bin; Zhao, Li-Juan; Engelhard, Herbert H.; Cerullo, Leonard; Lichtor, Terry; Byrne, Richard; Munoz, Lorenzo; Von Roenn, Kelvin; Rosseau, Gail L.; Glick, Roberta; Sherman, Chen; and Farooq, Khan, "Genomic expression discovery predicts pathways and opposing functions behind phenotypes" (2003). Neurosurgery. 1737.
https://scholar.barrowneuro.org/neurosurgery/1737