The Role of microRNA Markers in the Diagnosis, Treatment, and Outcome Prediction of Spinal Cord Injury

Authors

Nikolay L. Martirosyan, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA; Division of Neurosurgery, University of Arizona, Tucson, AZ, USA.Follow
Alessandro Carotenuto, College of Medicine - Phoenix, University of Arizona , Phoenix, AZ , USA.
Arpan A. Patel, College of Medicine - Phoenix, University of Arizona , Phoenix, AZ , USA.
M Yashar Kalani, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.Follow
Kaan Yagmurlu, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.
G Michael Lemole, Division of Neurosurgery, University of Arizona , Tucson, AZ , USA.
Mark C. Preul, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.
Nicholas Theodore, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.

Document Type

Article

Abstract

Spinal cord injury (SCI) is a devastating condition that affects many people worldwide. Treatment focuses on controlling secondary injury cascade and improving regeneration. It has recently been suggested that both the secondary injury cascade and the regenerative process are heavily regulated by microRNAs (miRNAs). The measurement of specific biomarkers could improve our understanding of the disease processes, and thereby provide clinicians with the opportunity to guide treatment and predict clinical outcomes after SCI. A variety of miRNAs exhibit important roles in processes of inflammation, cell death, and regeneration. These miRNAs can be used as diagnostic tools for predicting outcome after SCI. In addition, miRNAs can be used in the treatment of SCI and its symptoms. Significant laboratory and clinical evidence exist to show that miRNAs could be used as robust diagnostic and therapeutic tools for the treatment of patients with SCI. Further clinical studies are warranted to clarify the importance of each subtype of miRNA in SCI management.

Publication Date

1-1-2016

Publication Title

Frontiers in surgery

ISSN

2296-875X

Volume

3

First Page

56

PubMed ID

27878119

Recommended Citation

Martirosyan, Nikolay L.; Carotenuto, Alessandro; Patel, Arpan A.; Kalani, M Yashar; Yagmurlu, Kaan; Lemole, G Michael; Preul, Mark C.; and Theodore, Nicholas, "The Role of microRNA Markers in the Diagnosis, Treatment, and Outcome Prediction of Spinal Cord Injury" (2016). Neurosurgery. 1725.
https://scholar.barrowneuro.org/neurosurgery/1725